Assessment of Structural Intolerance and Durability
General Structure Information 1x3b TGFBI solution structure of the fas1 domain of human transforming growth factor-beta induced protein ig-h3 -1.0Å AUTH M.YONEYAMA,T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FAS1 DOMAIN OF HUMANTITL 2 TRANSFORMING GROWTH FACTOR-BETA INDUCED PROTEINTITL 3 IG-H3REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1x3b TGFBI solution structure of the fas1 domain of human transforming growth factor-beta induced protein ig-h3 -1.0Å AUTH M.YONEYAMA,T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FAS1 DOMAIN OF HUMANTITL 2 TRANSFORMING GROWTH FACTOR-BETA INDUCED PROTEINTITL 3 IG-H3REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1by2 LGALS3BP structure of m2bp scavenger receptor cysteine-rich domain 2.0Å AUTH E.HOHENESTER,T.SASAKI,R.TIMPLTITL CRYSTAL STRUCTURE OF A SCAVENGER RECEPTOR CYSTEINE-RICHTITL 2 DOMAIN SHEDS LIGHT ON AN ANCIENT SUPERFAMILY.REF NAT.STRUCT.BIOL. V. 6 228 1999REFN ISSN 1072-8368PMID 10074941DOI 10.1038/6669 Variant Set Distributions Mapped Variants
General Structure Information 4fww MST1R crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase 1.85Å AUTH K.L.CHAO,I.W.TSAI,C.CHEN,O.HERZBERGTITL CRYSTAL STRUCTURE OF THE SEMA-PSI EXTRACELLULAR DOMAIN OFTITL 2 HUMAN RON RECEPTOR TYROSINE KINASE.REF PLOS ONE V. 7 41912 2012REFN ESSN 1932-6203PMID 22848655DOI 10.1371/JOURNAL.PONE.0041912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1gr3 COL10A1 structure of the human collagen x nc1 trimer 2.0Å AUTH O.BOGIN,M.KVANSAKUL,E.ROM,J.SINGER,A.YAYON,AUTH 2 E.HOHENESTERTITL INSIGHT INTO SCHMID METAPHYSEAL CHONDRODYSPLASIATITL 2 FROM THE CRYSTAL STRUCTURE OF THE COLLAGEN X NC1TITL 3 DOMAIN TRIMER.REF STRUCTURE V. 10 165 2002REFN ISSN 0969-2126PMID 11839302DOI 10.1016/S0969-2126(02)00697-4 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3h3g PTH1R crystal structure of the extracellular domain of the human parathyroid hormone receptor (pth1r) in complex with parathyroid hormone-related protein (pthrp) 1.94Å AUTH A.A.PIOSZAK,N.R.PARKER,T.J.GARDELLA,H.E.XUTITL STRUCTURAL BASIS FOR PARATHYROID HORMONE-RELATED PROTEINTITL 2 BINDING TO THE PARATHYROID HORMONE RECEPTOR AND DESIGN OFTITL 3 CONFORMATION-SELECTIVE PEPTIDES.REF J.BIOL.CHEM. V. 284 28382 2009REFN ISSN 0021-9258PMID 19674967DOI […]
General Structure Information 4cc1 JAG1 notch ligand, jagged-1, contains an n-terminal c2 domain 2.84Å AUTH C.R.CHILAKURI,D.SHEPPARD,M.X.G.ILAGAN,L.R.HOLT,F.ABBOTT,AUTH 2 S.LIANG,R.KOPAN,P.A.HANDFORD,S.M.LEATITL STRUCTURAL ANALYSIS UNCOVERS LIPID-BINDING PROPERTIES OFTITL 2 NOTCH LIGANDSREF CELL REP. V. 5 861 2013REFN ISSN 2211-1247PMID 24239355DOI 10.1016/J.CELREP.2013.10.029 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4my2 NDP crystal structure of norrin in fusion with maltose binding protein 2.4Å AUTH J.KE,K.G.HARIKUMAR,C.ERICE,C.CHEN,X.GU,L.WANG,N.PARKER,AUTH 2 Z.CHENG,W.XU,B.O.WILLIAMS,K.MELCHER,L.J.MILLER,H.E.XUTITL STRUCTURE AND FUNCTION OF NORRIN IN ASSEMBLY AND ACTIVATIONTITL 2 OF A FRIZZLED 4-LRP5/6 COMPLEX.REF GENES DEV. V. 27 2305 2013REFN ISSN 0890-9369PMID 24186977DOI 10.1101/GAD.228544.113 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fww MST1R crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase 1.85Å AUTH K.L.CHAO,I.W.TSAI,C.CHEN,O.HERZBERGTITL CRYSTAL STRUCTURE OF THE SEMA-PSI EXTRACELLULAR DOMAIN OFTITL 2 HUMAN RON RECEPTOR TYROSINE KINASE.REF PLOS ONE V. 7 41912 2012REFN ESSN 1932-6203PMID 22848655DOI 10.1371/JOURNAL.PONE.0041912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1gr3 COL10A1 structure of the human collagen x nc1 trimer 2.0Å AUTH O.BOGIN,M.KVANSAKUL,E.ROM,J.SINGER,A.YAYON,AUTH 2 E.HOHENESTERTITL INSIGHT INTO SCHMID METAPHYSEAL CHONDRODYSPLASIATITL 2 FROM THE CRYSTAL STRUCTURE OF THE COLLAGEN X NC1TITL 3 DOMAIN TRIMER.REF STRUCTURE V. 10 165 2002REFN ISSN 0969-2126PMID 11839302DOI 10.1016/S0969-2126(02)00697-4 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants