3N3K.A | USP8

General Structure Information 3n3k USP8 the catalytic domain of usp8 in complex with a usp8 specific inhibitor 2.6Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K […]

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4GQS.C | CYP2C19

General Structure Information 4gqs CYP2C19 structure of human microsomal cytochrome p450 (cyp) 2c19 2.87Å AUTH R.L.REYNALD,S.SANSEN,C.D.STOUT,E.F.JOHNSONTITL STRUCTURAL CHARACTERIZATION OF HUMAN CYTOCHROME P450 2C19:TITL 2 ACTIVE SITE DIFFERENCES BETWEEN P450S 2C8, 2C9, AND 2C19.REF J.BIOL.CHEM. V. 287 44581 2012REFN ISSN 0021-9258PMID 23118231DOI 10.1074/JBC.M112.424895 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]

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1FB1.E | GCH1

General Structure Information 1fb1 GCH1 crystal structure of human gtp cyclohydrolase i 3.1Å AUTH G.AUERBACH,A.HERRMANN,A.BRACHER,G.BADER,M.GUTLICH,M.FISCHER,AUTH 2 M.NEUKAMM,M.GARRIDO-FRANCO,J.RICHARDSON,H.NAR,R.HUBER,AUTH 3 A.BACHERTITL ZINC PLAYS A KEY ROLE IN HUMAN AND BACTERIAL GTPTITL 2 CYCLOHYDROLASE I.REF PROC.NATL.ACAD.SCI.USA V. 97 13567 2000REFN ISSN 0027-8424PMID 11087827DOI 10.1073/PNAS.240463497 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]

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3RCH.B | DDC

General Structure Information 3rch DDC crystal structure of human aromatic l-amino acid decarboxylase (aadc) in the open conformation with llp and plp bound to chain-a and chain- b respectively 2.8Å AUTH G.GIARDINA,R.MONTIOLI,S.GIANNI,B.CELLINI,A.PAIARDINI,AUTH 2 C.B.VOLTATTORNI,F.CUTRUZZOLATITL OPEN CONFORMATION OF HUMAN DOPA DECARBOXYLASE REVEALS THETITL 2 MECHANISM OF PLP ADDITION TO GROUP II DECARBOXYLASES.REF PROC.NATL.ACAD.SCI.USA V. 108 20514 […]

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2V9Y.A | GART

General Structure Information 2v9y GART human aminoimidazole ribonucleotide synthetase 2.1Å AUTH M.WELIN,J.G.GROSSMANN,S.FLODIN,T.NYMAN,P.STENMARK,AUTH 2 L.TRESAUGUES,T.KOTENYOVA,I.JOHANSSON,P.NORDLUND,L.LEHTIOTITL STRUCTURAL STUDIES OF TRI-FUNCTIONAL HUMAN GART.REF NUCLEIC ACIDS RES. V. 38 7308 2010REFN ISSN 0305-1048PMID 20631005DOI 10.1093/NAR/GKQ595 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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3HNC.A | RRM1

General Structure Information 3hnc RRM1 crystal structure of human ribonucleotide reductase 1 bound to the effector ttp 2.41Å AUTH J.W.FAIRMAN,S.R.WIJERATHNA,M.F.AHMAD,H.XU,R.NAKANO,S.JHA,AUTH 2 J.PRENDERGAST,R.M.WELIN,S.FLODIN,A.ROOS,P.NORDLUND,Z.LI,AUTH 3 T.WALZ,C.G.DEALWISTITL STRUCTURAL BASIS FOR ALLOSTERIC REGULATION OF HUMANTITL 2 RIBONUCLEOTIDE REDUCTASE BY NUCLEOTIDE-INDUCEDTITL 3 OLIGOMERIZATION.REF NAT.STRUCT.MOL.BIOL. V. 18 316 2011REFN ISSN 1545-9993PMID 21336276DOI 10.1038/NSMB.2007 Variant Set Distributions Ripley’s K Analysis Plots Variant […]

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4KXU.A | TKT

General Structure Information 4kxu TKT human transketolase in covalent complex with donor ketose d-fructose- 6-phosphate 0.98Å AUTH S.LUDTKE,P.NEUMANN,K.M.ERIXON,F.LEEPER,R.KLUGER,R.FICNER,AUTH 2 K.TITTMANNTITL SUB-ANGSTROM-RESOLUTION CRYSTALLOGRAPHY REVEALS PHYSICALTITL 2 DISTORTIONS THAT ENHANCE REACTIVITY OF A COVALENT ENZYMATICTITL 3 INTERMEDIATE.REF NAT CHEM V. 5 762 2013REFNPMID 23965678DOI 10.1038/NCHEM.1728 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]

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2QK4.A | GART

General Structure Information 2qk4 GART human glycinamide ribonucleotide synthetase 2.45Å AUTH M.WELIN,J.G.GROSSMANN,S.FLODIN,T.NYMAN,P.STENMARK,AUTH 2 L.TRESAUGUES,T.KOTENYOVA,I.JOHANSSON,P.NORDLUND,L.LEHTIOTITL STRUCTURAL STUDIES OF TRI-FUNCTIONAL HUMAN GART.REF NUCLEIC ACIDS RES. V. 38 7308 2010REFN ISSN 0305-1048PMID 20631005DOI 10.1093/NAR/GKQ595 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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2OKN.A | PEPD

General Structure Information 2okn PEPD crystal strcture of human prolidase 2.45Å AUTH U.MUELLER,F.H.NIESEN,Y.ROSKE,F.GOETZ,J.BEHLKE,K.BUESSOW,AUTH 2 U.HEINEMANNTITL CRYSTAL STRUCTURE OF HUMAN PROLIDASE: THE MOLECULAR BASIS OFTITL 2 PD DISEASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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2O6L.B | UGT2B7

General Structure Information 2o6l UGT2B7 crystal structure of the udp-glucuronic acid binding domain of the human drug metabolizing udp-glucuronosyltransferase 2b7 1.8Å AUTH M.J.MILEY,A.K.ZIELINSKA,J.E.KEENAN,S.M.BRATTON,AUTH 2 A.RADOMINSKA-PANDYA,M.R.REDINBOTITL CRYSTAL STRUCTURE OF THE COFACTOR-BINDING DOMAINTITL 2 OF THE HUMAN PHASE II DRUG-METABOLISM ENZYMETITL 3 UDP-GLUCURONOSYLTRANSFERASE 2B7.REF J.MOL.BIOL. V. 369 498 2007REFN ISSN 0022-2836PMID 17442341DOI 10.1016/J.JMB.2007.03.066 Variant Set Distributions Mapped […]

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