Assessment of Structural Intolerance and Durability
General Structure Information 4kit PRPF8 crystal structure of human brr2 in complex with the prp8 jab1/mpn domain 3.6Å AUTH S.MOZAFFARI-JOVIN,T.WANDERSLEBEN,K.F.SANTOS,C.L.WILL,AUTH 2 R.LUHRMANN,M.C.WAHLTITL INHIBITION OF RNA HELICASE BRR2 BY THE C-TERMINAL TAIL OFTITL 2 THE SPLICEOSOMAL PROTEIN PRP8.REF SCIENCE V. 341 80 2013REFN ISSN 0036-8075PMID 23704370DOI 10.1126/SCIENCE.1237515 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4jon CEP170 crystal structure of a centrosomal protein 170kda, transcript variant beta (cep170) from homo sapiens at 2.15 a resolution (psi community target, sundstrom) 2.15Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)TITL CRYSTAL STRUCTURE OF A CENTROSOMAL PROTEIN 170KDA,TITL 2 TRANSCRIPT VARIANT BETA (CEP170) FROM HOMO SAPIENS AT 2.15 ATITL 3 RESOLUTION […]
General Structure Information 3kgr LAIR1 crystal structure of the human leukocyte-associated ig-like receptor-1 (lair-1) 1.8Å AUTH T.H.C.BRONDIJK,T.DE RUITER,J.BALLERING,H.WIENK,R.J.LEBBINK,AUTH 2 H.VAN INGEN,R.BOELENS,R.W.FARNDALE,L.MEYAARD,E.G.HUIZINGATITL CRYSTAL STRUCTURE AND COLLAGEN-BINDING SITE OF IMMUNETITL 2 INHIBITORY RECEPTOR LAIR-1: UNEXPECTED IMPLICATIONS FORTITL 3 COLLAGEN BINDING BY PLATELET RECEPTOR GPVIREF BLOOD V. 115 1364 2010REFN ISSN 0006-4971PMID 20007810DOI 10.1182/BLOOD-2009-10-246322 Variant Set Distributions Ripley’s […]
General Structure Information 4kng RNF43 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rn9 COX17 solution structure of human apocox17 -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,A.JANICKA,AUTH 2 M.MARTINELLI,H.KOZLOWSKI,P.PALUMAATITL A STRUCTURAL-DYNAMICAL CHARACTERIZATION OF HUMANTITL 2 COX17REF J.BIOL.CHEM. V. 283 7912 2008REFN ISSN 0021-9258PMID 18093982DOI 10.1074/JBC.M708016200 Variant Set Distributions Mapped Variants
General Structure Information 1gxe MYBPC3 central domain of cardiac myosin binding protein c -1.0Å AUTH S.IDOWU,M.GAUTEL,S.PERKINS,M.PFUHLTITL STRUCTURE, STABILITY AND DYNAMICS OF THE CENTRALTITL 2 DOMAIN OF CARDIAC MYOSIN BINDING PROTEIN CTITL 3 (MYBP-C): IMPLICATIONS FOR MULTIDOMAIN ASSEMBLYTITL 4 AND CAUSES FOR CARDIOMYOPATHYREF J.MOL.BIOL. V. 329 745 2003REFN ISSN 0022-2836PMID 12787675DOI 10.1016/S0022-2836(03)00425-X Variant Set Distributions Ripley’s […]
General Structure Information 4eku PTK2B crystal structure of ferm domain of proline-rich tyrosine kinase 2 3.25Å AUTH B.SAVARIMUTHU,R.LI,Y.WANGTITL CRYSTAL STRUCTURE OF THE FERM DOMAIN OF PROLINE-RICHTITL 2 TYROSINE KINASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2q5a PIN1 human pin1 bound to l-peptide 1.5Å AUTH Y.ZHANG,S.DAUM,D.WILDEMANN,X.Z.ZHOU,M.A.VERDECIA,M.E.BOWMAN,AUTH 2 C.LUCKE,T.HUNTER,K.P.LU,G.FISCHER,J.P.NOELTITL STRUCTURAL BASIS FOR HIGH-AFFINITY PEPTIDE INHIBITION OFTITL 2 HUMAN PIN1.REF ACS CHEM.BIOL. V. 2 320 2007REFN ISSN 1554-8929PMID 17518432DOI 10.1021/CB7000044 Variant Set Distributions Mapped Variants
General Structure Information 2i6k IDI1 crystal structure of human type i ipp isomerase complexed with a substrate analog 2.0Å AUTH C.ZHANG,L.LIU,H.XU,Z.WEI,Y.WANG,Y.LIN,W.GONGTITL CRYSTAL STRUCTURES OF HUMAN IPP ISOMERASE: NEWTITL 2 INSIGHTS INTO THE CATALYTIC MECHANISMREF J.MOL.BIOL. V. 366 1437 2007REFN ISSN 0022-2836PMID 17137593DOI 10.1016/J.JMB.2006.10.092 Variant Set Distributions Mapped Variants
General Structure Information 2kle PKD2 isic refined solution structure of the calcium binding domain of the c-terminal cytosolic domain of polycystin-2 -1.0Å AUTH F.H.SCHUMANN,H.HOFFMEISTER,M.SCHMIDT,R.BADER,AUTH 2 E.BESL,R.WITZGALL,H.R.KALBITZERTITL NMR-ASSIGNMENTS OF A CYTOSOLIC DOMAIN OF THETITL 2 C-TERMINUS OF POLYCYSTIN-2REF BIOMOL.NMR ASSIGN. V. 3 141 2009REFN ISSN 1874-2718PMID 19636966DOI 10.1007/S12104-009-9160-X Variant Set Distributions Mapped Variants