Assessment of Structural Intolerance and Durability
General Structure Information 2d8s MARCH8 solution structure of the ring domain of the human cellular modulator of immune recognition protein -1.0Å AUTH K.MIYAMOTO,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THE HUMANTITL 2 CELLULAR MODULATOR OF IMMUNE RECOGNITION PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2vns STEAP3 crystal structure of the membrane proximal oxidoreductase domain of human steap3, the dominant ferric reductase of the erythroid transferrin cycle 2.0Å AUTH A.K.SENDAMARAI,R.S.OHGAMI,M.D.FLEMING,C.M.LAWRENCETITL STRUCTURE OF THE MEMBRANE PROXIMAL OXIDOREDUCTASETITL 2 DOMAIN OF HUMAN STEAP3, THE DOMINANTTITL 3 FERRIREDUCTASE OF THE ERYTHROID TRANSFERRIN CYCLEREF PROC.NATL.ACAD.SCI.USA V. 105 7410 2008REFN ISSN 0027-8424PMID […]
General Structure Information 4dou ADIPOQ crystal structure of a single-chain trimer of human adiponectin globular domain 2.0Å AUTH X.MIN,B.LEMON,J.TANG,Q.LIU,R.ZHANG,N.WALKER,Y.LI,Z.WANGTITL CRYSTAL STRUCTURE OF A SINGLE-CHAIN TRIMER OF HUMANTITL 2 ADIPONECTIN GLOBULAR DOMAIN.REF FEBS LETT. V. 586 912 2012REFN ISSN 0014-5793PMID 22449980DOI 10.1016/J.FEBSLET.2012.02.024 Variant Set Distributions Mapped Variants
General Structure Information 2v9k PUS10 crystal structure of human pus10, a novel pseudouridine synthase. 2.0Å AUTH C.J.MCCLEVERTY,M.HORNSBY,G.SPRAGGON,A.KREUSCHTITL CRYSTAL STRUCTURE OF HUMAN PUS10, A NOVEL PSEUDOURIDINETITL 2 SYNTHASE.REF J.MOL.BIOL. V. 373 1243 2007REFN ISSN 0022-2836PMID 17900615DOI 10.1016/J.JMB.2007.08.053 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3v5q NTRK3 discovery of a selective trk inhibitor with efficacy in rodent cancer tumor models 2.2Å AUTH P.ALBAUGH,Y.FAN,Y.MI,F.SUN,F ADRIAN,N.LI,Y.YIA,Y.SARKISOVA,AUTH 2 A.KREUSCH,T.HOOD,M.LU,G.LIU,S.HUANG,Z.LIU,J.LOREN,AUTH 3 T.TUNTLAND,D.S.KARANEWSKY,H.M.SEIDEL,V.MOLTENITITL DISCOVERY OF GNF-5837, A SELECTIVE TRK INHIBITOR WITHTITL 2 EFFICACY IN RODENT CANCER TUMOR MODELSREF ACS MED.CHEM.LETT. 2012REFN ISSN 1948-5875DOI 10.1021/ML200261D Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3bq7 DGKD sam domain of diacylglycerol kinase delta1 (e35g) 2.9Å AUTH B.T.HARADA,M.J.KNIGHT,S.IMAI,F.QIAO,R.RAMACHANDER,AUTH 2 M.R.SAWAYA,M.GINGERY,F.SAKANE,J.U.BOWIETITL REGULATION OF ENZYME LOCALIZATION BYTITL 2 POLYMERIZATION: POLYMER FORMATION BY THE SAMTITL 3 DOMAIN OF DIACYLGLYCEROL KINASE DELTA1REF STRUCTURE V. 16 380 2008REFN ISSN 0969-2126PMID 18334213DOI 10.1016/J.STR.2007.12.017 Variant Set Distributions Mapped Variants
General Structure Information 1r79 DGKD solution structure of the c1 domain of the human diacylglycerol kinase delta -1.0Å AUTH K.MIYAMOTO,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C1 DOMAIN OF THE HUMANTITL 2 DIACYLGLYCEROL KINASE DELTAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4bst RSPO1 structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form 4.3Å AUTH W.C.PENG,W.DE LAU,F.FORNERIS,J.C.M.GRANNEMAN,M.HUCH,AUTH 2 H.CLEVERS,P.GROSTITL STRUCTURE OF STEM CELL GROWTH FACTOR R-SPONDIN 1 IN COMPLEXTITL 2 WITH THE ECTODOMAIN OF ITS RECEPTOR LGR5.REF CELL REP. V. 3 1885 2013REFN ISSN 2211-1247PMID 23809763DOI 10.1016/J.CELREP.2013.06.009 Variant […]
General Structure Information 3pp2 ARHGAP27 crystal structure of the pleckstrin homology domain of arhgap27 1.42Å AUTH L.SHEN,W.TEMPEL,Y.TONG,L.NEDYALKOVA,Y.LI,A.K.WERNIMONT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OFTITL 2 ARHGAP27REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3she MAPKAPK3 novel atp-competitive mk2 inhibitors with potent biochemical and cell- based activity throughout the series 2.25Å AUTH A.OUBRIE,A.KAPTEIN,E.DE ZWART,N.HOOGENBOOM,R.GOORDEN,AUTH 2 B.VAN DE KAR,M.VAN HOEK,V.DE KIMPE,R.VAN DER HEIJDEN,AUTH 3 J.BORSBOOM,B.KAZEMIER,J.DE ROOS,M.SCHEFFERS,J.LOMMERSE,AUTH 4 C.SCHULTZ-FADEMRECHT,T.BARFTITL NOVEL ATP COMPETITIVE MK2 INHIBITORS WITH POTENT BIOCHEMICALTITL 2 AND CELL-BASED ACTIVITY THROUGHOUT THE SERIES.REF BIOORG.MED.CHEM.LETT. V. 22 613 […]