Assessment of Structural Intolerance and Durability
General Structure Information 1x5h NEO1 the solution structure of the third fibronectin type iii domain of human neogenin -1.0Å AUTH N.TOCHIO,A.SASAGAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE THIRD FIBRONECTINTITL 2 TYPE III DOMAIN OF HUMAN NEOGENINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wxp THOC1 solution structure of the death domain of nuclear matrix protein p84 -1.0Å AUTH T.N.NIRAULA,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE DEATH DOMAIN OF NUCLEARTITL 2 MATRIX PROTEIN P84REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4is7 CASKIN2 crystal structure of the caskin2 sam domain tandem 2.75Å AUTH KWAN J.J.,E.SMIRNOVA,V.SARIDAKIS,DONALDSON L.W.TITL CRYSTAL STRUCTURE OF THE CASKIN2 SAM DOMAIN TANDEMREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rc4 KAT6A crystal structure of the hat domain of the human moz protein 3.0Å AUTH M.A.HOLBERT,T.SIKORSKI,J.CARTEN,D.SNOWFLACK,S.HODAWADEKAR,AUTH 2 R.MARMORSTEINTITL THE HUMAN MONOCYTIC LEUKEMIA ZINC FINGER HISTONETITL 2 ACETYLTRANSFERASE DOMAIN CONTAINS DNA-BINDING ACTIVITYTITL 3 IMPLICATED IN CHROMATIN TARGETING.REF J.BIOL.CHEM. V. 282 36603 2007REFN ISSN 0021-9258PMID 17925393DOI 10.1074/JBC.M705812200 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2rex RND1 crystal structure of the effector domain of plxnb1 bound with rnd1 gtpase 2.3Å AUTH Y.TONG,W.TEMPEL,L.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PLXNB1 BOUNDTITL 2 WITH RND1 GTPASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ooi NSD1 crystal structure of human histone-lysine n-methyltransferase nsd1 set domain in complex with s-adenosyl-l-methionine 1.75Å AUTH Q.QIAO,Y.LI,Z.CHEN,M.WANG,D.REINBERG,R.M.XUTITL THE STRUCTURE OF NSD1 REVEALS AN AUTOREGULATORY MECHANISMTITL 2 UNDERLYING HISTONE H3K36 METHYLATIONREF J.BIOL.CHEM. V. 286 8361 2010REFN ISSN 0021-9258PMID 21196496DOI 10.1074/JBC.M110.204115 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2egm TRIM41 solution structure of the zf-b_box domain from human tripartite motif protein 41 -1.0Å AUTH K.INOUE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-B_BOX DOMAIN FROMTITL 2 HUMAN TRIPARTITE MOTIF PROTEIN 41REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dmf RNF25 an extended conformation of the rwd domain of human ring finger protein 25 -1.0Å AUTH M.YONEYAMA,N.TOCHIO,S.KOSHIBA,S.WATABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL AN EXTENDED CONFORMATION OF THE RWD DOMAIN OFTITL 2 HUMAN RING FINGER PROTEIN 25REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3al2 TOPBP1 crystal structure of topbp1 brct7/8 2.0Å AUTH C.C.LEUNG,Z.GONG,J.CHEN,J.N.GLOVERTITL MOLECULAR BASIS OF BACH1/FANCJ RECOGNITION BY TOPBP1 IN DNATITL 2 REPLICATION CHECKPOINT CONTROLREF J.BIOL.CHEM. V. 286 4292 2011REFN ISSN 0021-9258PMID 21127055DOI 10.1074/JBC.M110.189555 Variant Set Distributions Mapped Variants
General Structure Information 2ecn RNF141 solution structure of the ring domain of the human ring finger protein 141 -1.0Å AUTH K.MIYAMOTO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THE HUMANTITL 2 RING FINGER PROTEIN 141REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants