Assessment of Structural Intolerance and Durability
General Structure Information 4ljq RNF31 crystal structure of the catalytic core of e3 ligase hoip 2.45Å AUTH B.STIEGLITZ,R.R.RANA,M.G.KOLIOPOULOS,A.C.MORRIS-DAVIES,AUTH 2 V.SCHAEFFER,E.CHRISTODOULOU,S.HOWELL,N.R.BROWN,I.DIKIC,AUTH 3 K.RITTINGERTITL STRUCTURAL BASIS FOR LIGASE-SPECIFIC CONJUGATION OF LINEARTITL 2 UBIQUITIN CHAINS BY HOIP.REF NATURE V. 503 422 2013REFN ISSN 0028-0836PMID 24141947DOI 10.1038/NATURE12638 Variant Set Distributions Mapped Variants
General Structure Information 2cm0 NGLY1 the pub domain functions as a p97 binding module in human peptide n-glycanase. 1.9Å AUTH M.D.ALLEN,A.BUCHBERGER,M.BYCROFTTITL THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULETITL 2 IN HUMAN PEPTIDE N-GLYCANASE.REF J.BIOL.CHEM. V. 281 25502 2006REFN ISSN 0021-9258PMID 16807242DOI 10.1074/JBC.M601173200 Variant Set Distributions Mapped Variants
General Structure Information 3pd7 TOPBP1 crystal structure of the sixth brct domain of human topbp1 1.26Å AUTH J.LEE,C.XU,G.CUI,J.R.THOMPSON,G.MERTITL CRYSTAL STRUCTURE OF THE SIXTH BRCT DOMAIN OF HUMAN TOPBP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3mb3 PHIP crystal structure of the second bromodomain of pleckstrin homology domain interacting protein (phip) 2.25Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 1uey NRCAM solution structure of the first fibronectin type iii domain of human kiaa0343 protein -1.0Å AUTH C.ZHAO,T.KIGAWA,Y.MUTO,S.KOSHIBA,N.TOCHIO,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN KIAA0343 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2yt4 DGCR8 crystal structure of human dgcr8 core 2.6Å AUTH S.Y.SOHN,W.J.BAE,J.J.KIM,K.H.YEOM,V.N.KIM,Y.CHOTITL CRYSTAL STRUCTURE OF HUMAN DGCR8 COREREF NAT.STRUCT.MOL.BIOL. V. 14 847 2007REFN ISSN 1545-9993PMID 17704815DOI 10.1038/NSMB1294 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2hh2 KHSRP solution structure of the fourth kh domain of ksrp -1.0Å AUTH M.F.GARCIA-MAYORAL,D.HOLLINGWORTH,L.MASINO,AUTH 2 I.DIAZ-MORENO,G.KELLY,R.GHERZI,C.F.CHOU,C.Y.CHEN,AUTH 3 A.RAMOSTITL THE STRUCTURE OF THE C-TERMINAL KH DOMAINS OF KSRPTITL 2 REVEALS A NONCANONICAL MOTIF IMPORTANT FOR MRNATITL 3 DEGRADATION.REF STRUCTURE V. 15 485 2007REFN ISSN 0969-2126PMID 17437720DOI 10.1016/J.STR.2007.03.006 Variant Set Distributions Mapped Variants
General Structure Information 2cod ARAP2 solution structure of the n-terminal ph domain of arap2 protein from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL PH DOMAIN OFTITL 2 ARAP2 PROTEIN FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2csz SYTL4 solution structure of the ring domain of the synaptotagmin- like protein 4 -1.0Å AUTH K.MIYAMOTO,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THETITL 2 SYNAPTOTAGMIN-LIKE PROTEIN 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ldz STAM crystal structure of human stam1 vhs domain in complex with ubiquitin 2.6Å AUTH X.REN,J.H.HURLEYTITL VHS DOMAINS OF ESCRT-0 COOPERATE IN HIGH-AVIDITYTITL 2 BINDING TO POLYUBIQUITINATED CARGO.REF EMBO J. V. 29 1045 2010REFN ISSN 0261-4189PMID 20150893DOI 10.1038/EMBOJ.2010.6 Variant Set Distributions Mapped Variants