Assessment of Structural Intolerance and Durability
General Structure Information 2dnp RBM14 solution structure of rna binding domain 2 in rna-binding protein 14 -1.0Å AUTH M.KUSUHARA,K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,AUTH 2 T.TERADA,M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN 2 INTITL 2 RNA-BINDING PROTEIN 14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yse MAGI1 solution structure of the second ww domain from the human membrane-associated guanylate kinase, ww and pdz domain- containing protein 1. magi-1 -1.0Å AUTH S.OHNISHI,M.SATO,S.KOSHIBA,T.HARADA,S.WATANABE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND WW DOMAIN FROMTITL 2 THE HUMAN MEMBRANE-ASSOCIATED GUANYLATE KINASE, WWTITL 3 AND PDZ DOMAIN-CONTAINING PROTEIN 1. MAGI-1REF TO BE […]
General Structure Information 1r42 ACE2 native human angiotensin converting enzyme-related carboxypeptidase (ace2) 2.2Å AUTH P.TOWLER,B.STAKER,S.G.PRASAD,S.MENON,J.TANG,T.PARSONS,AUTH 2 D.RYAN,M.FISHER,D.WILLIAMS,N.A.DALES,M.A.PATANE,AUTH 3 M.W.PANTOLIANOTITL ACE2 X-RAY STRUCTURES REVEAL A LARGE HINGE-BENDING MOTIONTITL 2 IMPORTANT FOR INHIBITOR BINDING AND CATALYSIS.REF J.BIOL.CHEM. V. 279 17996 2004REFN ISSN 0021-9258PMID 14754895DOI 10.1074/JBC.M311191200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4jxh CYTH2 complexe of arno sec7 domain with the protein-protein interaction inhibitor n-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at ph 8.5 1.47Å AUTH J.ROUHANA,F.HOH,S.ESTARAN,C.HENRIQUET,Y.BOUBLIK,A.KERKOUR,AUTH 2 R.TROUILLARD,J.MARTINEZ,M.PUGNIERE,A.PADILLA,A.CHAVANIEUTITL FRAGMENT-BASED IDENTIFICATION OF A LOCUS IN THE SEC7 DOMAINTITL 2 OF ARNO FOR THE DESIGN OF PROTEIN-PROTEIN INTERACTIONTITL 3 INHIBITORSREF J.MED.CHEM. V. 56 8497 2013REFN ISSN 0022-2623PMID 24112024DOI 10.1021/JM4009357 Variant Set […]
General Structure Information 2e6s UHRF2 solution structure of the phd domain in ring finger protein 107 -1.0Å AUTH S.KADIRVEL,F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,AUTH 2 T.TERADA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PHD DOMAIN IN RINGTITL 2 FINGER PROTEIN 107REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3k1z HDHD3 crystal structure of human haloacid dehalogenase-like hydrolase domain containing 3 (hdhd3) 1.55Å AUTH E.UGOCHUKWU,K.GUO,W.W.YUE,E.PILKA,K.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN HALOACID DEHALOGENASE-LIKETITL 2 HYDROLASE DOMAIN CONTAINING 3 (HDHD3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rlo AGAP2 split ph domain of pi3-kinase enhancer -1.0Å AUTH J.YAN,W.WEN,L.N.CHAN,M.ZHANGTITL SPLIT PLECKSTRIN HOMOLOGY DOMAIN-MEDIATEDTITL 2 CYTOPLASMIC-NUCLEAR LOCALIZATION OF PI3-KINASETITL 3 ENHANCER GTPASEREF J.MOL.BIOL. V. 378 425 2008REFN ISSN 0022-2836PMID 18371979DOI 10.1016/J.JMB.2008.02.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wyn CNN2 solution structure of the ch domain of human calponin-2 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CH DOMAIN OF HUMANTITL 2 CALPONIN-2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2djr ZBED2 solution structures of the c2h2 type zinc finger domain of human zinc finger bed domain containing protein 2 -1.0Å AUTH M.SATO,A.SASAGAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE C2H2 TYPE ZINC FINGERTITL 2 DOMAIN OF HUMAN ZINC FINGER BED DOMAIN CONTAININGTITL 3 PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 2yu4 NSMCE2 solution structure of the sp-ring domain in non-smc element 2 homolog (mms21, s. cerevisiae) -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TARADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SP-RING DOMAIN INTITL 2 NON-SMC ELEMENT 2 HOMOLOG (MMS21, S. CEREVISIAE)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants