General Structure Information 1n3l YARS crystal structure of a human aminoacyl-trna synthetase cytokine 1.18Å AUTH X.-L.YANG,R.J.SKENE,D.E.MCREE,P.SCHIMMELTITL CRYSTAL STRUCTURE OF A HUMAN AMINOACYL-TRNA SYNTHETASETITL 2 CYTOKINEREF PROC.NATL.ACAD.SCI.USA V. 99 15369 2002REFN ISSN 0027-8424PMID 12427973DOI 10.1073/PNAS.242611799 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o96 PSMD7 crystal structure of the metal-free dimeric human mov34 mpn domain (residues 1-177) 3.0Å AUTH M.SANCHES,B.S.C.ALVES,N.I.T.ZANCHIN,B.G.GUIMARAESTITL THE CRYSTAL STRUCTURE OF THE HUMAN MOV34 MPN DOMAIN REVEALSTITL 2 A METAL-FREE DIMERREF J.MOL.BIOL. V. 370 846 2007REFN ISSN 0022-2836PMID 17559875DOI 10.1016/J.JMB.2007.04.084 Variant Set Distributions Mapped Variants
General Structure Information 3enm MAP2K6 the structure of the map2k mek6 reveals an autoinhibitory dimer 2.35Å AUTH X.MIN,R.AKELLA,H.HE,J.M.HUMPHREYS,S.E.TSUTAKAWA,S.J.LEE,AUTH 2 J.A.TAINER,M.H.COBB,E.J.GOLDSMITHTITL THE STRUCTURE OF THE MAP2K MEK6 REVEALS AN AUTOINHIBITORYTITL 2 DIMERREF STRUCTURE V. 17 96 2009REFN ISSN 0969-2126PMID 19141286DOI 10.1016/J.STR.2008.11.007 Variant Set Distributions Mapped Variants
General Structure Information 4igg CTNNA1 full-length human alpha-catenin crystal structure 3.66Å AUTH E.S.RANGARAJAN,T.IZARDTITL DIMER ASYMMETRY DEFINES ALPHA-CATENIN INTERACTIONS.REF NAT.STRUCT.MOL.BIOL. V. 20 188 2013REFN ISSN 1545-9993PMID 23292143DOI 10.1038/NSMB.2479 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1gh7 CSF2RB crystal structure of the complete extracellular domain of the beta- common receptor of il-3, il-5, and gm-csf 3.0Å AUTH P.D.CARR,S.E.GUSTIN,A.P.CHURCH,J.M.MURPHY,S.C.FORD,D.A.MANN,AUTH 2 D.M.WOLTRING,I.WALKER,D.L.OLLIS,I.G.YOUNGTITL STRUCTURE OF THE COMPLETE EXTRACELLULAR DOMAIN OF THE COMMONTITL 2 BETA SUBUNIT OF THE HUMAN GM-CSF, IL-3, AND IL-5 RECEPTORSTITL 3 REVEALS A NOVEL DIMER CONFIGURATION.REF CELL(CAMBRIDGE,MASS.) V. […]
General Structure Information 3rch DDC crystal structure of human aromatic l-amino acid decarboxylase (aadc) in the open conformation with llp and plp bound to chain-a and chain- b respectively 2.8Å AUTH G.GIARDINA,R.MONTIOLI,S.GIANNI,B.CELLINI,A.PAIARDINI,AUTH 2 C.B.VOLTATTORNI,F.CUTRUZZOLATITL OPEN CONFORMATION OF HUMAN DOPA DECARBOXYLASE REVEALS THETITL 2 MECHANISM OF PLP ADDITION TO GROUP II DECARBOXYLASES.REF PROC.NATL.ACAD.SCI.USA V. 108 20514 […]
General Structure Information 2oph DPP4 human dipeptidyl peptidase iv in complex with an alpha amino acid inhibitor 2.4Å AUTH J.L.DUFFY,B.A.KIRK,L.WANG,G.J.EIERMANN,H.HE,B.LEITING,AUTH 2 K.A.LYONS,R.A.PATEL,S.B.PATEL,A.PETROV,G.SCAPIN,J.K.WU,AUTH 3 N.A.THORNBERRY,A.E.WEBERTITL 4-AMINOPHENYLALANINE AND 4-AMINOCYCLOHEXYLALANINETITL 2 DERIVATIVES AS POTENT, SELECTIVE, AND ORALLY BIOAVAILABLETITL 3 INHIBITORS OF DIPEPTIDYL PEPTIDASE IV.REF BIOORG.MED.CHEM.LETT. V. 17 2879 2007REFN ISSN 0960-894XPMID 17350841DOI 10.1016/J.BMCL.2007.02.066 Variant Set Distributions Ripley’s K […]
General Structure Information 1itv MMP9 dimeric form of the haemopexin domain of mmp9 1.95Å AUTH H.CHA,E.KOPETZKI,R.HUBER,M.LANZENDORFER,AUTH 2 H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE ADAPTIVE MOLECULARTITL 2 RECOGNITION BY MMP9.REF J.MOL.BIOL. V. 320 1065 2002REFN ISSN 0022-2836PMID 12126625DOI 10.1016/S0022-2836(02)00558-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1i0e CKM crystal structure of creatine kinase from human muscle 3.5Å AUTH Y.Q.SHEN,L.TANG,H.M.ZHOU,Z.J.LINTITL STRUCTURE OF HUMAN MUSCLE CREATINE KINASE.REF ACTA CRYSTALLOGR.,SECT.D V. 57 1196 2001REFN ISSN 0907-4449PMID 11517911 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1gk4 VIM human vimentin coil 2b fragment (cys2) 2.3Å AUTH S.STRELKOV,H.HERRMANN,N.GEISLER,T.WEDIG,AUTH 2 R.ZIMBELMANN,U.AEBI,P.BURKHARDTITL CONSERVED SEGMENTS 1A AND 2B OF THE INTERMEDIATETITL 2 FILAMENT DIMER: THEIR ATOMIC STRUCTURES AND ROLETITL 3 IN FILAMENT ASSEMBLY.REF EMBO J. V. 21 1255 2002REFN ISSN 0261-4189PMID 11889032DOI 10.1093/EMBOJ/21.6.1255 Variant Set Distributions Mapped Variants