Assessment of Structural Intolerance and Durability
General Structure Information 2ek1 RBM12 crystal structure of rna-binding motif of human rna-binding protein 12 2.0Å AUTH IHSANAWATI,Y.BESSHO,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF RNA-BINDING MOTIF OF HUMANTITL 2 RNA-BINDING PROTEIN 12REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1jpy IL17F crystal structure of il-17f 2.85Å AUTH S.G.HYMOWITZ,E.H.FILVAROFF,J.P.YIN,J.LEE,L.CAI,P.RISSER,AUTH 2 M.MARUOKA,W.MAO,J.FOSTER,R.F.KELLEY,G.PAN,A.L.GURNEY,AUTH 3 A.M.DE VOS,M.A.STAROVASNIKTITL IL-17S ADOPT A CYSTINE KNOT FOLD: STRUCTURE AND ACTIVITY OFTITL 2 A NOVEL CYTOKINE, IL-17F, AND IMPLICATIONS FOR RECEPTORTITL 3 BINDING.REF EMBO J. V. 20 5332 2001REFN ISSN 0261-4189PMID 11574464DOI 10.1093/EMBOJ/20.19.5332 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2xqq DYNLL2 human dynein light chain (dynll2) in complex with an in vitro evolved peptide (ac-srgtqte). 1.31Å AUTH P.RAPALI,L.RADNAI,D.SUVEGES,V.HARMAT,F.TOLGYESI,AUTH 2 W.Y.WAHLGREN,G.KATONA,L.NYITRAY,G.PALTITL DIRECTED EVOLUTION REVEALS THE BINDING MOTIF PREFERENCE OFTITL 2 THE LC8/DYNLL HUB PROTEIN AND PREDICTS LARGE NUMBERS OFTITL 3 NOVEL BINDERS IN THE HUMAN PROTEOMEREF PLOS ONE V. 6 18818 2011REFN […]
General Structure Information 3t30 NPM2 human nucleoplasmin (npm2): a histone chaperone in oocytes and early embryos 1.9Å AUTH O.PLATONOVA,I.V.AKEY,J.F.HEAD,C.W.AKEYTITL CRYSTAL STRUCTURE AND FUNCTION OF HUMAN NUCLEOPLASMINTITL 2 (NPM2): A HISTONE CHAPERONE IN OOCYTES AND EMBRYOS.REF BIOCHEMISTRY V. 50 8078 2011REFN ISSN 0006-2960PMID 21863821DOI 10.1021/BI2006652 Variant Set Distributions Mapped Variants
General Structure Information 2kdd CDCA8 solution structure of the conserved c-terminal dimerization domain of borealin -1.0Å AUTH E.BOURHIS,A.LINGEL,Q.PHUNG,W.J.FAIRBROTHER,AUTH 2 A.G.COCHRANTITL PHOSPHORYLATION OF A BOREALIN DIMERIZATION DOMAINTITL 2 IS REQUIRED FOR PROPER CHROMOSOME SEGREGATION.REF BIOCHEMISTRY V. 48 6783 2009REFN ISSN 0006-2960PMID 19530738DOI 10.1021/BI900530V Variant Set Distributions Mapped Variants
General Structure Information 3twj ROCK1 rho-associated protein kinase 1 (rock 1) in complex with rki1447 2.9Å AUTH R.A.PATEL,K.D.FORINASH,R.PIREDDU,Y.SUN,N.SUN,M.P.MARTIN,AUTH 2 E.SCHONBRUNN,N.J.LAWRENCE,S.M.SEBTITITL RKI-1447 IS A POTENT INHIBITOR OF THE RHO-ASSOCIATED ROCKTITL 2 KINASES WITH ANTI-INVASIVE AND ANTITUMOR ACTIVITIES INTITL 3 BREAST CANCER.REF CANCER RES. V. 72 5025 2012REFN ISSN 0008-5472PMID 22846914DOI 10.1158/0008-5472.CAN-12-0954 Variant Set Distributions Ripley’s K […]
General Structure Information 1upt GOLGA4 structure of a complex of the golgin-245 grip domain with arl1 1.7Å AUTH B.PANIC,O.PERISIC,D.B.VEPRINTSEV,R.L.WILLIAMS,AUTH 2 S.MUNROTITL STRUCTURAL BASIS FOR ARL1-DEPENDENT TARGETING OFTITL 2 HOMODIMERIC GRIP DOMAINS TO THE GOLGI APPARATUSREF MOL.CELL V. 12 863 2003REFN ISSN 1097-2765PMID 14580338DOI 10.1016/S1097-2765(03)00356-3 Variant Set Distributions Mapped Variants
General Structure Information 2lcx ERBB4 spatial structure of the erbb4 dimeric tm domain -1.0Å AUTH E.V.BOCHAROV,K.S.MINEEV,M.V.GONCHARUK,A.S.ARSENIEVTITL STRUCTURAL AND THERMODYNAMIC INSIGHT INTO THE PROCESS OFTITL 2 WEAK DIMERIZATION OF THE ERBB4 TRANSMEMBRANE DOMAIN BYTITL 3 SOLUTION NMR.REF BIOCHIM.BIOPHYS.ACTA V.1818 2158 2012REFN ISSN 0006-3002PMID 22579757DOI 10.1016/J.BBAMEM.2012.05.001 Variant Set Distributions Mapped Variants
General Structure Information 1y7q ZNF174 mammalian scan domain dimer is a domain-swapped homologue of the hiv capsid c-terminal domain -1.0Å AUTH D.IVANOV,J.R.STONE,J.L.MAKI,T.COLLINS,G.WAGNERTITL MAMMALIAN SCAN DOMAIN DIMER IS A DOMAIN-SWAPPEDTITL 2 HOMOLOG OF THE HIV CAPSID C-TERMINAL DOMAINREF MOL.CELL V. 17 137 2005REFN ISSN 1097-2765PMID 15629724DOI 10.1016/J.MOLCEL.2004.12.015 Variant Set Distributions Mapped Variants
General Structure Information 2qa5 SEPT2 crystal structure of sept2 g-domain 3.4Å AUTH M.SIRAJUDDIN,M.FARKASOVSKY,F.HAUER,D.KUHLMANN,AUTH 2 I.G.MACARA,M.WEYAND,H.STARK,A.WITTINGHOFERTITL STRUCTURAL INSIGHT INTO FILAMENT FORMATION BYTITL 2 MAMMALIAN SEPTINS.REF NATURE V. 449 311 2007REFN ISSN 0028-0836PMID 17637674DOI 10.1038/NATURE06052 Variant Set Distributions Mapped Variants