General Structure Information 2jis CSAD human cysteine sulfinic acid decarboxylase (csad) in complex with plp. 1.6Å AUTH R.COLLINS,M.MOCHE,C.ARROWSMITH,H.BERGLUND,R.BUSAM,AUTH 2 L.G.DAHLGREN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,B.M.HALLBERG,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,T.KOTENYOVA,L.LEHTIO,AUTH 5 P.NORDLUND,T.NYMAN,D.OGG,C.PERSSON,J.SAGEMARK,AUTH 6 P.STENMARK,M.SUNDSTROM,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 8 L.HOLMBERG-SCHIAVONETITL THE CRYSTAL STRUCTURE OF HUMAN CYSTEINE SULFINICTITL 2 ACID DECARBOXYLASE (CSAD)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2okj GAD1 the x-ray crystal structure of the 67kda isoform of glutamic acid decarboxylase (gad67) 2.3Å AUTH G.FENALTI,R.H.P.LAW,A.M.BUCKLE,C.LANGENDORF,K.TUCK,AUTH 2 C.J.ROSADO,N.G.FAUX,K.MAHMOOD,C.S.HAMPE,J.P.BANGA,AUTH 3 M.WILCE,J.SCHMIDBERGER,J.ROSSJOHN,O.EL-KABBANI,AUTH 4 R.N.PIKE,A.I.SMITH,I.R.MACKAY,M.J.ROWLEY,AUTH 5 J.C.WHISSTOCKTITL GABA PRODUCTION BY GLUTAMIC ACID DECARBOXYLASE ISTITL 2 REGULATED BY A DYNAMIC CATALYTIC LOOP.REF NAT.STRUCT.MOL.BIOL. V. 14 280 2007REFN ISSN 1545-9993PMID 17384644DOI 10.1038/NSMB1228 Variant Set Distributions […]
General Structure Information 2wm1 ACMSD the crystal structure of human alpha-amino-beta- carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between nad synthesis and glycolysis 2.01Å AUTH S.GARAVAGLIA,S.PEROZZI,L.GALEAZZI,N.RAFFAELLI,AUTH 2 M.RIZZITITL THE CRYSTAL STRUCTURE OF HUMAN ALPHA-AMINO-BETA-TITL 2 CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASETITL 3 IN COMPLEX WITH 1,3-DIHYDROXYACETONEPHOSPHATETITL 4 SUGGESTS A REGULATORY LINK BETWEEN NAD SYNTHESISTITL 5 […]
General Structure Information 4gll UXS1 crystal structure of human udp-xylose synthase. 2.5Å AUTH S.J.POLIZZI,R.M.WALSH,W.B.PEEPLES,J.M.LIM,L.WELLS,Z.A.WOODTITL HUMAN UDP-ALPHA-D-XYLOSE SYNTHASE AND ESCHERICHIA COLI ARNATITL 2 CONSERVE A CONFORMATIONAL SHUNT THAT CONTROLS WHETHER XYLOSETITL 3 OR 4-KETO-XYLOSE IS PRODUCED.REF BIOCHEMISTRY V. 51 8844 2012REFN ISSN 0006-2960PMID 23072385DOI 10.1021/BI301135B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2okk GAD2 the x-ray crystal structure of the 65kda isoform of glutamic acid decarboxylase (gad65) 2.3Å AUTH G.FENALTI,R.H.LAW,A.M.BUCKLE,C.LANGENDORF,K.TUCK,C.J.ROSADO,AUTH 2 N.G.FAUX,K.MAHMOOD,C.S.HAMPE,J.P.BANGA,M.WILCE,AUTH 3 J.SCHMIDBERGER,J.ROSSJOHN,O.EL-KABBANI,R.N.PIKE,A.I.SMITH,AUTH 4 I.R.MACKAY,M.J.ROWLEY,J.C.WHISSTOCKTITL GABA PRODUCTION BY GLUTAMIC ACID DECARBOXYLASE IS REGULATEDTITL 2 BY A DYNAMIC CATALYTIC LOOP.REF NAT.STRUCT.MOL.BIOL. V. 14 280 2007REFN ISSN 1545-9993PMID 17384644DOI 10.1038/NSMB1228 Variant Set Distributions Ripley’s K […]
General Structure Information 2okk GAD2 the x-ray crystal structure of the 65kda isoform of glutamic acid decarboxylase (gad65) 2.3Å AUTH G.FENALTI,R.H.LAW,A.M.BUCKLE,C.LANGENDORF,K.TUCK,C.J.ROSADO,AUTH 2 N.G.FAUX,K.MAHMOOD,C.S.HAMPE,J.P.BANGA,M.WILCE,AUTH 3 J.SCHMIDBERGER,J.ROSSJOHN,O.EL-KABBANI,R.N.PIKE,A.I.SMITH,AUTH 4 I.R.MACKAY,M.J.ROWLEY,J.C.WHISSTOCKTITL GABA PRODUCTION BY GLUTAMIC ACID DECARBOXYLASE IS REGULATEDTITL 2 BY A DYNAMIC CATALYTIC LOOP.REF NAT.STRUCT.MOL.BIOL. V. 14 280 2007REFN ISSN 1545-9993PMID 17384644DOI 10.1038/NSMB1228 Variant Set Distributions Ripley’s K […]
General Structure Information 3d4j MVD crystal structure of human mevalonate diphosphate decarboxylase 2.4Å AUTH N.E.VOYNOVA,Z.FU,K.P.BATTAILE,T.J.HERDENDORF,AUTH 2 J.J.KIM,H.M.MIZIORKOTITL HUMAN MEVALONATE DIPHOSPHATE DECARBOXYLASE:TITL 2 CHARACTERIZATION, INVESTIGATION OF THE MEVALONATETITL 3 DIPHOSPHATE BINDING SITE, AND CRYSTAL STRUCTURE.REF ARCH.BIOCHEM.BIOPHYS. V. 480 58 2008REFN ISSN 0003-9861PMID 18823933DOI 10.1016/J.ABB.2008.08.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3rch DDC crystal structure of human aromatic l-amino acid decarboxylase (aadc) in the open conformation with llp and plp bound to chain-a and chain- b respectively 2.8Å AUTH G.GIARDINA,R.MONTIOLI,S.GIANNI,B.CELLINI,A.PAIARDINI,AUTH 2 C.B.VOLTATTORNI,F.CUTRUZZOLATITL OPEN CONFORMATION OF HUMAN DOPA DECARBOXYLASE REVEALS THETITL 2 MECHANISM OF PLP ADDITION TO GROUP II DECARBOXYLASES.REF PROC.NATL.ACAD.SCI.USA V. 108 20514 […]
General Structure Information 1msv AMD1 the s68a s-adenosylmethionine decarboxylase proenzyme processing mutant. 1.75Å AUTH W.D.TOLBERT,Y.ZHANG,S.E.COTTET,E.M.BENNETT,AUTH 2 J.L.EKSTROM,A.E.PEGG,S.E.EALICKTITL MECHANISM OF HUMAN S-ADENOSYLMETHIONINETITL 2 DECARBOXYLASE PROENZYME PROCESSING AS REVEALED BYTITL 3 THE STRUCTURE OF THE S68A MUTANT.REF BIOCHEMISTRY V. 42 2386 2003REFN ISSN 0006-2960PMID 12600205DOI 10.1021/BI0268854 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3gw3 UROD human urod mutant k297n 1.7Å AUTH C.A.WARBY,J.D.PHILLIPS,H.A.BERGONIA,F.G.WHITBY,C.P.HILL,AUTH 2 J.P.KUSHNERTITL STRUCTURAL AND KINETIC CHARACTERIZATION OF MUTANT HUMANTITL 2 UROPORPHYRINOGEN DECARBOXYLASES.REF CELL MOL BIOL V. 55 40 2009REF 2 (NOISY-LE-GRAND)REFNPMID 19656450 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants