General Structure Information
| PDB ID | 2okk |
| HGNC Gene Label(s) | GAD2 |
| Structure Name | the x-ray crystal structure of the 65kda isoform of glutamic acid decarboxylase (gad65) |
| Resolution | 2.3Å |
| Reference | AUTH G.FENALTI,R.H.LAW,A.M.BUCKLE,C.LANGENDORF,K.TUCK,C.J.ROSADO,AUTH 2 N.G.FAUX,K.MAHMOOD,C.S.HAMPE,J.P.BANGA,M.WILCE,AUTH 3 J.SCHMIDBERGER,J.ROSSJOHN,O.EL-KABBANI,R.N.PIKE,A.I.SMITH,AUTH 4 I.R.MACKAY,M.J.ROWLEY,J.C.WHISSTOCKTITL GABA PRODUCTION BY GLUTAMIC ACID DECARBOXYLASE IS REGULATEDTITL 2 BY A DYNAMIC CATALYTIC LOOP.REF NAT.STRUCT.MOL.BIOL. V. 14 280 2007REFN ISSN 1545-9993PMID 17384644DOI 10.1038/NSMB1228 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 482 |
| Number Of SNVs | 108 |
| Number Of Permutations | 59277 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.076 |
| p-value | 0.015 |
COSMIC
| Number Of Residues | 482 |
| Number Of SNVs | 15 |
| Number Of Permutations | 5963 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.019 |
| p-value | 0.673 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 108 |
| Number Of COSMIC SNVs | 15 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.023 |
| p-value | 0.812 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
