Assessment of Structural Intolerance and Durability
General Structure Information 2k7p FLNA filamin a ig-like domains 16-17 -1.0Å AUTH O.K.HEIKKINEN,S.RUSKAMO,P.V.KONAREV,D.I.SVERGUN,AUTH 2 T.IIVANAINEN,S.M.HEIKKINEN,P.PERMI,H.KOSKELA,AUTH 3 I.KILPELAINEN,J.YLANNETITL ATOMIC STRUCTURES OF TWO NOVEL IMMUNOGLOBULIN-LIKETITL 2 DOMAIN PAIRS IN THE ACTIN CROSS-LINKING PROTEINTITL 3 FILAMINREF J.BIOL.CHEM. V. 284 25450 2009REFN ISSN 0021-9258PMID 19622754DOI 10.1074/JBC.M109.019661 Variant Set Distributions Mapped Variants
General Structure Information 3cnk FLNA crystal structure of the dimerization domain of human filamin a 1.65Å AUTH M.-D.SEO,S.-H.SEOK,H.IM,A.-R.KWON,S.-J.LEE,AUTH 2 H.-R.KIM,Y.CHO,D.PARK,B.-J.LEETITL CRYSTAL STRUCTURE OF THE DIMERIZATION DOMAIN OFTITL 2 HUMAN FILAMIN AREF PROTEINS V. 75 258 2008REFN ISSN 0887-3585PMID 19137608DOI 10.1002/PROT.22336 Variant Set Distributions Mapped Variants
General Structure Information 3rgh FLNA structure of filamin a immunoglobulin-like repeat 10 from homo sapiens 2.44Å AUTH R.C.PAGE,J.G.CLARK,S.MISRATITL STRUCTURE OF FILAMIN A IMMUNOGLOBULIN-LIKE REPEAT 10 FROMTITL 2 HOMO SAPIENS.REF ACTA CRYSTALLOGR.,SECT.F V. 67 871 2011REFN ESSN 1744-3091PMID 21821884DOI 10.1107/S1744309111024249 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2k3t FLNA solution structure of ig-like domain 23 from human filamin a -1.0Å AUTH F.NAKAMURA,O.HEIKKINEN,O.T.PENTIKAINEN,T.M.OSBORN,AUTH 2 K.E.KASZA,D.A.WEITZ,O.KUPIAINEN,P.PERMI,AUTH 3 I.KILPELAINEN,J.YLANNE,J.H.HARTWIG,T.P.STOSSELTITL MOLECULAR BASIS OF FILAMIN A-FILGAP INTERACTIONTITL 2 AND ITS IMPAIRMENT IN CONGENITAL DISORDERSTITL 3 ASSOCIATED WITH FILAMIN A MUTATIONSREF PLOS ONE V. 4 E4928 2009REFN ESSN 1932-6203PMID 19293932DOI 10.1371/JOURNAL.PONE.0004928 Variant Set Distributions Mapped […]
General Structure Information 2wfn FLNA filamin a actin binding domain 3.2Å AUTH S.RUSKAMO,J.YLANNETITL STRUCTURE OF THE HUMAN FILAMIN A ACTIN-BINDING DOMAINREF ACTA CRYSTALLOGR.,SECT.D V. 65 1217 2009REFN ISSN 0907-4449PMID 19923718DOI 10.1107/S0907444909037330 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2j3s FLNA crystal structure of the human filamin a ig domains 19 to 21 2.5Å AUTH Y.LAD,T.-R.KIEMA,P.JIANG,O.T.PENTIKANEN,C.H.COLES,AUTH 2 I.D.CAMPBELL,D.A.CALDERWOOD,J.YLANNETITL STRUCTURE OF THREE TANDEM FILAMIN DOMAINS REVEALSTITL 2 AUTO-INHIBITION OF LIGAND-BINDING.REF EMBO J. V. 26 3993 2007REFN ISSN 0261-4189PMID 17690686DOI 10.1038/SJ.EMBOJ.7601827 Variant Set Distributions Mapped Variants
General Structure Information 4m9p FLNA crystal structure of the human filamin a ig-like domains 3-5 1.72Å AUTH R.SETHI,J.SEPPALA,H.TOSSAVAINEN,M.YLILAURI,S.RUSKAMO,AUTH 2 O.T.PENTIKAINEN,U.PENTIKAINEN,P.PERMI,J.YLANNETITL A NOVEL STRUCTURAL UNIT IN THE N-TERMINAL REGION OFTITL 2 FILAMINS.REF J.BIOL.CHEM. V. 289 8588 2014REFN ISSN 0021-9258PMID 24469451DOI 10.1074/JBC.M113.537456 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ud1 ANK1 crystal structure of zu5a-zu5b domains of human erythrocyte ankyrin 2.0Å AUTH M.YASUNAGA,J.J.IPSARO,A.MONDRAGONTITL STRUCTURALLY SIMILAR BUT FUNCTIONALLY DIVERSE ZU5 DOMAINS INTITL 2 HUMAN ERYTHROCYTE ANKYRIN.REF J.MOL.BIOL. V. 417 336 2012REFN ISSN 0022-2836PMID 22310050DOI 10.1016/J.JMB.2012.01.041 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3f7p ITGB4 crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]