Assessment of Structural Intolerance and Durability
General Structure Information 2xph SENP1 crystal structure of human senp1 with the bound cobalt 2.4Å AUTH V.RIMSA,T.EADSFORTH,R.T.HAY,W.N.HUNTERTITL THE ROLE OF CO2+ IN THE CRYSTALLIZATION OF HUMAN SENP1 ANDTITL 2 COMMENTS ON THE LIMITATIONS OF AUTOMATED REFINEMENTTITL 3 PROTOCOLSREF ACTA CRYSTALLOGR.,SECT.F V. 67 442 2011REFN ISSN 1744-3091PMID 21505236DOI 10.1107/S1744309111005835 Variant Set Distributions Mapped Variants
General Structure Information 1m6d CTSF crystal structure of human cathepsin f 1.7Å AUTH J.R.SOMOZA,J.T.PALMER,J.D.HOTITL THE CRYSTAL STRUCTURE OF HUMAN CATHEPSIN F AND ITSTITL 2 IMPLICATIONS FOR THE DEVELOPMENT OF NOVEL IMMUNOMODULATORSREF J.MOL.BIOL. V. 322 559 2002REFN ISSN 0022-2836PMID 12225749DOI 10.1016/S0022-2836(02)00780-5 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1deu CTSZ crystal structure of human procathepsin x: a cysteine protease with the proregion covalently linked to the active site cysteine 1.7Å AUTH J.SIVARAMAN,D.K.NAGLER,R.ZHANG,R.MENARD,M.CYGLERTITL CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN X: A CYSTEINETITL 2 PROTEASE WITH THE PROREGION COVALENTLY LINKED TO THE ACTIVETITL 3 SITE CYSTEINE.REF J.MOL.BIOL. V. 295 939 2000REFN ISSN 0022-2836PMID […]
General Structure Information 3cz9 PARK7 crystal structure of e18l dj-1 1.15Å AUTH A.C.WITT,M.LAKSHMINARASIMHAN,B.C.REMINGTON,S.HASIM,AUTH 2 E.POZHARSKI,M.A.WILSONTITL CYSTEINE PKA DEPRESSION BY A PROTONATED GLUTAMICTITL 2 ACID IN HUMAN DJ-1.REF BIOCHEMISTRY V. 47 7430 2008REFN ISSN 0006-2960PMID 18570440DOI 10.1021/BI800282D Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fgu LGMN crystal structure of prolegumain 3.9Å AUTH E.DALL,H.BRANDSTETTERTITL MECHANISTIC AND STRUCTURAL STUDIES ON LEGUMAIN EXPLAIN ITSTITL 2 ZYMOGENICITY, DISTINCT ACTIVATION PATHWAYS, AND REGULATION.REF PROC.NATL.ACAD.SCI.USA V. 110 10940 2013REFN ISSN 0027-8424PMID 23776206DOI 10.1073/PNAS.1300686110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fjv OTUB2 crystal structure of human otubain2 and ubiquitin complex 2.05Å AUTH M.ALTUN,T.S.WALTER,H.B.KRAMER,P.HERR,A.IPHOFER,J.BOSTROM,AUTH 2 Y.DAVID,A.KOMSANY,N.TERNETTE,A.NAVON,D.I.STUART,J.REN,AUTH 3 B.M.KESSLERTITL THE HUMAN OTUBAIN2-UBIQUITIN STRUCTURE PROVIDES INSIGHTSTITL 2 INTO THE CLEAVAGE SPECIFICITY OF POLY-UBIQUITIN-LINKAGES.REF PLOS ONE V. 10 15344 2015REFN ESSN 1932-6203PMID 25590432DOI 10.1371/JOURNAL.PONE.0115344 Variant Set Distributions Mapped Variants
General Structure Information 1hy9 CARTPT cocaine and amphetamine regulated transcript -1.0Å AUTH S.LUDVIGSEN,L.THIM,A.M.BLOM,B.S.WULFFTITL SOLUTION STRUCTURE OF THE SATIETY FACTOR, CART,TITL 2 REVEALS NEW FUNCTIONALITY OF A WELL-KNOWN FOLD.REF BIOCHEMISTRY V. 40 9082 2001REFN ISSN 0006-2960PMID 11478874DOI 10.1021/BI010433U Variant Set Distributions Mapped Variants
General Structure Information 2i7a CAPN13 domain iv of human calpain 13 1.8Å AUTH J.R.WALKER,K.NG,T.L.DAVIS,R.RAVULAPALLI,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,E.M.NEWMAN,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF HUMAN CALPAIN 13REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1cb5 BLMH human bleomycin hydrolase. 2.59Å AUTH P.A.OFARRELL,F.GONZALEZ,W.ZHENG,S.A.JOHNSTON,L.JOSHUA-TORTITL CRYSTAL STRUCTURE OF HUMAN BLEOMYCIN HYDROLASE, ATITL 2 SELF-COMPARTMENTALIZING CYSTEINE PROTEASE.REF STRUCTURE FOLD.DES. V. 7 619 1999REFN ISSN 0969-2126PMID 10404591DOI 10.1016/S0969-2126(99)80083-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1hp8 CMC4 solution structure of human p8-mtcp1, a cysteine-rich protein encoded by the mtcp1 oncogene,reveals a new alpha- helical assembly motif, nmr, minimized average structure -1.0Å AUTH P.BARTHE,Y.S.YANG,L.CHICHE,F.HOH,M.P.STRUB,AUTH 2 L.GUIGNARD,J.SOULIER,M.H.STERN,H.VAN TILBEURGH,AUTH 3 J.M.LHOSTE,C.ROUMESTANDTITL SOLUTION STRUCTURE OF HUMAN P8MTCP1, ATITL 2 CYSTEINE-RICH PROTEIN ENCODED BY THE MTCP1TITL 3 ONCOGENE, REVEALS A NEW ALPHA-HELICAL […]