Assessment of Structural Intolerance and Durability
General Structure Information 3k6g TERF2IP crystal structure of rap1 and trf2 complex 1.95Å AUTH Y.CHEN,R.RAI,Z.R.ZHOU,J.KANOH,C.RIBEYRE,Y.YANG,H.ZHENG,AUTH 2 P.DAMAY,F.WANG,H.TSUJII,Y.HIRAOKA,D.SHORE,H.Y.HU,S.CHANG,AUTH 3 M.LEITITL A CONSERVED MOTIF WITHIN RAP1 HAS DIVERSIFIED ROLES INTITL 2 TELOMERE PROTECTION AND REGULATION IN DIFFERENT ORGANISMS.REF NAT.STRUCT.MOL.BIOL. V. 18 213 2011REFN ISSN 1545-9993PMID 21217703DOI 10.1038/NSMB.1974 Variant Set Distributions Mapped Variants
General Structure Information 3gix TXNL4B crystal structure of human splicing factor dim2 1.33Å AUTH T.C.JIN,F.GUO,Y.T.WANG,A.HOWARD,Y.Z.ZHANGTITL CRYSTAL STRUCTURE OF HUMAN SPLICING FACTOR DIM2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ve7 SPC25 crystal structure of a bonsai version of the human ndc80 complex 2.88Å AUTH C.CIFERRI,S.PASQUALATO,E.SCREPANTI,G.VARETTI,S.SANTAGUIDA,AUTH 2 G.DOS REIS,A.MAIOLICA,J.POLKA,J.G.DE LUCA,P.DE WULF,M.SALEK,AUTH 3 J.RAPPSILBER,C.A.MOORES,E.D.SALMON,A.MUSACCHIOTITL IMPLICATIONS FOR KINETOCHORE-MICROTUBULE ATTACHMENT FROMTITL 2 THE STRUCTURE OF AN ENGINEERED NDC80 COMPLEXREF CELL(CAMBRIDGE,MASS.) V. 133 427 2008REFN ISSN 0092-8674PMID 18455984DOI 10.1016/J.CELL.2008.03.020 Variant Set Distributions Mapped Variants
General Structure Information 3f9y SETD8 structural insights into lysine multiple methylation by set domain methyltransferases, set8-y334f / h4-lys20me1 / adohcy 1.5Å AUTH J.F.COUTURE,L.M.DIRK,J.S.BRUNZELLE,R.L.HOUTZ,R.C.TRIEVELTITL STRUCTURAL ORIGINS FOR THE PRODUCT SPECIFICITY OF SET DOMAINTITL 2 PROTEIN METHYLTRANSFERASES.REF PROC.NATL.ACAD.SCI.USA V. 105 20659 2008REFN ISSN 0027-8424PMID 19088188DOI 10.1073/PNAS.0806712105 Variant Set Distributions Mapped Variants
General Structure Information 3c5h ARHGAP35 crystal structure of the ras homolog domain of human grlf1 (p190rhogap) 1.8Å AUTH L.SHEN,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RAS HOMOLOG DOMAIN OFTITL 2 HUMAN GRLF1 (P190RHOGAP).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wvr CDT1 human cdt1:geminin complex 3.3Å AUTH V.DE MARCO,P.J.GILLESPIE,A.LI,N.KARANTZELIS,AUTH 2 E.CHRISTODOULOU,R.KLOMPMAKER,S.VAN GERWEN,A.FISH,AUTH 3 M.V.PETOUKHOV,M.S.ILIOU,Z.LYGEROU,R.H.MEDEMA,AUTH 4 J.J.BLOW,D.I.SVERGUN,S.TARAVIRAS,A.PERRAKISTITL QUATERNARY STRUCTURE OF THE HUMAN CDT1-GEMININTITL 2 COMPLEX REGULATES DNA REPLICATION LICENSING.REF PROC.NATL.ACAD.SCI.USA V. 106 19807 2009REFN ISSN 0027-8424PMID 19906994DOI 10.1073/PNAS.0905281106 Variant Set Distributions Mapped Variants
General Structure Information 3fk2 ARHGAP35 crystal structure of the rhogap domain of human glucocorticoid receptor dna-binding factor 1 2.8Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF HUMANTITL 2 GLUCOCORTICOID RECEPTOR DNA-BINDING FACTOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3if8 ZWILCH crystal structure of zwilch, a member of the rzz kinetochore complex 2.55Å AUTH F.CIVRIL,A.WEHENKEL,F.M.GIORGI,S.SANTAGUIDA,A.DI FONZO,AUTH 2 G.GRIGOREAN,F.D.CICCARELLI,A.MUSACCHIOTITL STRUCTURAL ANALYSIS OF THE RZZ COMPLEX REVEALS COMMONTITL 2 ANCESTRY WITH MULTISUBUNIT VESICLE TETHERING MACHINERY.REF STRUCTURE V. 18 616 2010REFN ISSN 0969-2126PMID 20462495DOI 10.1016/J.STR.2010.02.014 Variant Set Distributions Mapped Variants
General Structure Information 3if8 ZWILCH crystal structure of zwilch, a member of the rzz kinetochore complex 2.55Å AUTH F.CIVRIL,A.WEHENKEL,F.M.GIORGI,S.SANTAGUIDA,A.DI FONZO,AUTH 2 G.GRIGOREAN,F.D.CICCARELLI,A.MUSACCHIOTITL STRUCTURAL ANALYSIS OF THE RZZ COMPLEX REVEALS COMMONTITL 2 ANCESTRY WITH MULTISUBUNIT VESICLE TETHERING MACHINERY.REF STRUCTURE V. 18 616 2010REFN ISSN 0969-2126PMID 20462495DOI 10.1016/J.STR.2010.02.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3zhp CAB39L human mst3 (stk24) in complex with mo25beta 2.9Å AUTH Y.MEHELLOU,D.R.ALESSI,T.J.MACARTNEY,M.SZKLARZ,S.KNAPP,AUTH 2 J.M.ELKINSTITL STRUCTURAL INSIGHTS INTO THE ACTIVATION OF MST3 BY MO25.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 431 604 2013REFN ISSN 0006-291XPMID 23296203DOI 10.1016/J.BBRC.2012.12.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants