Assessment of Structural Intolerance and Durability
General Structure Information 3l82 FBXO4 x-ray crystal structure of trf1 and fbx4 complex 2.4Å AUTH Z.ZENG,W.WANG,Y.YANG,Y.CHEN,X.YANG,J.A.DIEHL,X.LIU,M.LEITITL STRUCTURAL BASIS OF SELECTIVE UBIQUITINATION OF TRF1 BYTITL 2 SCF(FBX4)REF DEV.CELL V. 18 214 2010REFN ISSN 1534-5807PMID 20159592DOI 10.1016/J.DEVCEL.2010.01.007 Variant Set Distributions Mapped Variants
General Structure Information 4afl ING4 the crystal structure of the ing4 dimerization domain reveals the functional organization of the ing family of chromatin binding proteins. 2.28Å AUTH S.CULURGIONI,I.G.MUNOZ,A.MORENO,A.PALACIOS,M.VILLATE,AUTH 2 I.PALMERO,G.MONTOYA,F.J.BLANCOTITL CRYSTAL STRUCTURE OF INHIBITOR OF GROWTH 4 (ING4)TITL 2 DIMERIZATION DOMAIN REVEALS FUNCTIONAL ORGANIZATION OF INGTITL 3 FAMILY OF CHROMATIN-BINDING PROTEINS.REF J.BIOL.CHEM. V. 287 10876 […]
General Structure Information 2m6n FBXO5 3d solution structure of emi1 (early mitotic inhibitor 1) -1.0Å AUTH J.J.FRYE,N.G.BROWN,G.PETZOLD,E.R.WATSON,C.R.GRACE,A.NOURSE,AUTH 2 M.A.JARVIS,R.W.KRIWACKI,J.M.PETERS,H.STARK,B.A.SCHULMANTITL ELECTRON MICROSCOPY STRUCTURE OF HUMAN APC/C(CDH1)-EMI1TITL 2 REVEALS MULTIMODAL MECHANISM OF E3 LIGASE SHUTDOWN.REF NAT.STRUCT.MOL.BIOL. V. 20 827 2013REFN ISSN 1545-9993PMID 23708605DOI 10.1038/NSMB.2593 Variant Set Distributions Mapped Variants
General Structure Information 1jhj ANAPC10 crystal structure of the apc10/doc1 subunit of the human anaphase-promoting complex 1.6Å AUTH K.S.WENDT,H.C.VODERMAIER,U.JACOB,C.GIEFFERS,AUTH 2 M.GMACHL,J.M.PETERS,R.HUBER,P.SONDERMANNTITL CRYSTAL STRUCTURE OF THE APC10/DOC1 SUBUNIT OF THETITL 2 HUMAN ANAPHASE-PROMOTING COMPLEX.REF NAT.STRUCT.BIOL. V. 8 784 2001REFN ISSN 1072-8368PMID 11524682DOI 10.1038/NSB0901-784 Variant Set Distributions Mapped Variants
General Structure Information 3a6p XPO5 crystal structure of exportin-5:rangtp:pre-mirna complex 2.92Å AUTH C.OKADA,E.YAMASHITA,S.J.LEE,S.SHIBATA,J.KATAHIRA,A.NAKAGAWA,AUTH 2 Y.YONEDA,T.TSUKIHARATITL A HIGH-RESOLUTION STRUCTURE OF THE PRE-MICRORNA NUCLEARTITL 2 EXPORT MACHINERYREF SCIENCE V. 326 1275 2009REFN ISSN 0036-8075PMID 19965479DOI 10.1126/SCIENCE.1178705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2y7b ANLN crystal structure of the ph domain of human actin-binding protein anillin anln 1.9Å AUTH M.VOLLMAR,J.WANG,T.KROJER,J.ELKINS,P.FILIPPAKOPOULOS,AUTH 2 E.UGOCHUKWU,R.COCKING,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE PH DOMAIN OF HUMAN ACTIN-BINDINGTITL 2 PROTEIN ANILLIN ANLNREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2r3a SUV39H2 methyltransferase domain of human suppressor of variegation 3-9 homolog 2 2.0Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vhf CYLD structure of the cyld usp domain 2.8Å AUTH D.KOMANDER,C.J.LORD,H.SCHEEL,S.SWIFT,K.HOFMANN,AUTH 2 A.ASHWORTH,D.BARFORDTITL THE STRUCTURE OF THE CYLD USP DOMAIN EXPLAINS ITSTITL 2 SPECIFICITY FOR LYS63-LINKED POLYUBIQUITIN ANDTITL 3 REVEALS A B-BOX MODULEREF MOL.CELL.BIOL. V. 29 451 2008REFN ISSN 0270-7306PMID 18313383DOI 10.1016/J.MOLCEL.2007.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3q2e BRWD1 crystal structure of the second bromodomain of human bromodomain and wd repeat-containing protein 1 isoform a (wdr9) 1.74Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 2rmn TP63 the solution structure of the p63 dna-binding domain -1.0Å AUTH A.ENTHART,J.FURRER,A.DEHNER,H.KESSLERTITL SOLUTION STRUCTURE AND BINDING STUDIES OF THE P63TITL 2 DNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants