Assessment of Structural Intolerance and Durability
General Structure Information 3c5h ARHGAP35 crystal structure of the ras homolog domain of human grlf1 (p190rhogap) 1.8Å AUTH L.SHEN,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RAS HOMOLOG DOMAIN OFTITL 2 HUMAN GRLF1 (P190RHOGAP).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rfi EHMT1 crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide 1.59Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3tgx IL21R il-21:il21r complex 2.8Å AUTH O.J.HAMMING,L.KANG,A.SVENSSON,J.L.KARLSEN,H.RAHBEK-NIELSEN,AUTH 2 S.R.PALUDAN,S.A.HJORTH,K.BONDENSGAARD,R.HARTMANNTITL THE CRYSTAL STRUCTURE OF THE INTERLEUKIN 21 RECEPTOR BOUNDTITL 2 TO INTERLEUKIN 21 REVEALS THAT A SUGAR CHAIN INTERACTINGTITL 3 WITH THE WSXWS MOTIF IS AN INTEGRAL PART OF THE INTERLEUKINTITL 4 21 RECEPTOR.REF J.BIOL.CHEM. 2012REFN ESSN 1083-351XPMID 22235133DOI 10.1074/JBC.M111.311084 Variant Set Distributions […]
General Structure Information 3tgx IL21 il-21:il21r complex 2.8Å AUTH O.J.HAMMING,L.KANG,A.SVENSSON,J.L.KARLSEN,H.RAHBEK-NIELSEN,AUTH 2 S.R.PALUDAN,S.A.HJORTH,K.BONDENSGAARD,R.HARTMANNTITL THE CRYSTAL STRUCTURE OF THE INTERLEUKIN 21 RECEPTOR BOUNDTITL 2 TO INTERLEUKIN 21 REVEALS THAT A SUGAR CHAIN INTERACTINGTITL 3 WITH THE WSXWS MOTIF IS AN INTEGRAL PART OF THE INTERLEUKINTITL 4 21 RECEPTOR.REF J.BIOL.CHEM. 2012REFN ESSN 1083-351XPMID 22235133DOI 10.1074/JBC.M111.311084 Variant Set Distributions […]
General Structure Information 1x3s RAB18 crystal structure of human rab18 in complex with gppnhp 1.32Å AUTH M.KUKIMOTO-NIINO,K.MURAYAMA,L.CHEN,Z.J.LIU,AUTH 2 B.C.WANG,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF HUMAN RAB18 IN COMPLEX WITHTITL 2 GPPNHPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kiu FOXP1 solution structure and backbone dynamics of the dna-binding domain of foxp1: insight into its domain swapping -1.0Å AUTH Y.P.CHU,C.H.CHANG,J.H.SHIU,Y.T.CHANG,C.Y.CHEN,W.J.CHUANGTITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THE DNA-BINDINGTITL 2 DOMAIN OF FOXP1: INSIGHT INTO ITS DOMAIN SWAPPING AND DNATITL 3 BINDING.REF PROTEIN SCI. V. 20 908 2011REFN ISSN 0961-8368PMID 21416545DOI 10.1002/PRO.626 […]
General Structure Information 3if8 ZWILCH crystal structure of zwilch, a member of the rzz kinetochore complex 2.55Å AUTH F.CIVRIL,A.WEHENKEL,F.M.GIORGI,S.SANTAGUIDA,A.DI FONZO,AUTH 2 G.GRIGOREAN,F.D.CICCARELLI,A.MUSACCHIOTITL STRUCTURAL ANALYSIS OF THE RZZ COMPLEX REVEALS COMMONTITL 2 ANCESTRY WITH MULTISUBUNIT VESICLE TETHERING MACHINERY.REF STRUCTURE V. 18 616 2010REFN ISSN 0969-2126PMID 20462495DOI 10.1016/J.STR.2010.02.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3zhp CAB39L human mst3 (stk24) in complex with mo25beta 2.9Å AUTH Y.MEHELLOU,D.R.ALESSI,T.J.MACARTNEY,M.SZKLARZ,S.KNAPP,AUTH 2 J.M.ELKINSTITL STRUCTURAL INSIGHTS INTO THE ACTIVATION OF MST3 BY MO25.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 431 604 2013REFN ISSN 0006-291XPMID 23296203DOI 10.1016/J.BBRC.2012.12.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gwf RNF41 structure of a usp8-nrdp1 complex 2.3Å AUTH G.V.AVVAKUMOV,J.R.WALKER,S.XUE,P.J.FINERTY JR.,F.MACKENZIE,AUTH 2 E.M.NEWMAN,S.DHE-PAGANONTITL AMINO-TERMINAL DIMERIZATION, NRDP1-RHODANESE INTERACTION,TITL 2 AND INHIBITED CATALYTIC DOMAIN CONFORMATION OF THETITL 3 UBIQUITIN-SPECIFIC PROTEASE 8 (USP8).REF J.BIOL.CHEM. V. 281 38061 2006REFN ISSN 0021-9258PMID 17035239DOI 10.1074/JBC.M606704200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4kt1 LGR4 complex of r-spondin 1 with lgr4 extracellular domain 2.5Å AUTH D.L.WANG,B.HUANG,S.ZHANG,X.YU,W.WU,X.Q.WANGTITL STRUCTURAL BASIS FOR R-SPONDIN RECOGNITION BY LGR4/5/6TITL 2 RECEPTORSREF GENES DEV. V. 27 1339 2013REFN ISSN 0890-9369PMID 23756652DOI 10.1101/GAD.219360.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants