Assessment of Structural Intolerance and Durability
General Structure Information 2vhf CYLD structure of the cyld usp domain 2.8Å AUTH D.KOMANDER,C.J.LORD,H.SCHEEL,S.SWIFT,K.HOFMANN,AUTH 2 A.ASHWORTH,D.BARFORDTITL THE STRUCTURE OF THE CYLD USP DOMAIN EXPLAINS ITSTITL 2 SPECIFICITY FOR LYS63-LINKED POLYUBIQUITIN ANDTITL 3 REVEALS A B-BOX MODULEREF MOL.CELL.BIOL. V. 29 451 2008REFN ISSN 0270-7306PMID 18313383DOI 10.1016/J.MOLCEL.2007.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2fe4 RAB6B the crystal structure of human neuronal rab6b in its inactive gdp-bound form 2.3Å AUTH I.GARCIA-SAEZ,S.TCHERNIUK,F.KOZIELSKITITL THE STRUCTURE OF HUMAN NEURONAL RAB6B IN THETITL 2 ACTIVE AND INACTIVE FORM.REF ACTA CRYSTALLOGR.,SECT.D V. 62 725 2006REFN ISSN 0907-4449PMID 16790928DOI 10.1107/S0907444906015319 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2z0b GPCPD1 crystal structure of cbm20 domain of human putative glycerophosphodiester phosphodiesterase 5 (kiaa1434) 2.0Å AUTH S.SAIJO,A.NISHINO,S.KISHISHITA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF CBM20 DOMAIN OF HUMAN PUTATIVETITL 2 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 5 (KIAA1434)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4bn2 KIF15 the crystal structure of kinesin-like protein kif15 2.7Å AUTH M.KLEJNOT,A.FALNIKAR,V.ULAGANATHAN,R.A.CROSS,P.W.BAAS,AUTH 2 F.KOZIELSKITITL THE CRYSTAL STRUCTURE AND BIOCHEMICAL CHARACTERIZATION OFTITL 2 KIF15: A BIFUNCTIONAL MOLECULAR MOTOR INVOLVED IN BIPOLARTITL 3 SPINDLE FORMATION AND NEURONAL DEVELOPMENTREF ACTA CRYSTALLOGR.,SECT.D V. 70 123 2014REFN ISSN 0907-4449PMID 24419385DOI 10.1107/S1399004713028721 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2pz1 ARHGEF4 crystal structure of auto-inhibited asef 2.25Å AUTH N.MITIN,L.BETTS,M.E.YOHE,C.J.DER,J.SONDEK,K.L.ROSSMANTITL RELEASE OF AUTOINHIBITION OF ASEF BY APC LEADS TO CDC42TITL 2 ACTIVATION AND TUMOR SUPPRESSION.REF NAT.STRUCT.MOL.BIOL. V. 14 814 2007REFN ISSN 1545-9993PMID 17704816DOI 10.1038/NSMB1290 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ht9 GLRX2 the structure of dimeric human glutaredoxin 2 1.9Å AUTH C.JOHANSSON,K.L.KAVANAGH,O.GILEADI,U.OPPERMANNTITL REVERSIBLE SEQUESTRATION OF ACTIVE SITE CYSTEINES IN ATITL 2 2FE-2S-BRIDGED DIMER PROVIDES A MECHANISM FOR GLUTAREDOXIN 2TITL 3 REGULATION IN HUMAN MITOCHONDRIAREF J.BIOL.CHEM. V. 282 3077 2007REFN ISSN 0021-9258PMID 17121859DOI 10.1074/JBC.M608179200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1x5w ZFP64 solution structure of the c2h2 type zinc-binding domain of human zinc finger protein 64, isoforms 1 and 2 -1.0Å AUTH M.YONEYAMA,S.KOSHIBA,N.TOCHIO,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC-BINDINGTITL 2 DOMAIN OF HUMAN ZINC FINGER PROTEIN 64, ISOFORMS 1TITL 3 AND 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]
General Structure Information 1zvd SMURF2 regulation of smurf2 ubiquitin ligase activity by anchoring the e2 to the hect domain 2.1Å AUTH A.A.OGUNJIMI,D.J.BRIANT,N.PECE-BARBARA,C.LE ROY,AUTH 2 G.M.DI GUGLIELMO,P.KAVSAK,R.K.RASMUSSEN,B.T.SEET,F.SICHERI,AUTH 3 J.L.WRANATITL REGULATION OF SMURF2 UBIQUITIN LIGASE ACTIVITY BY ANCHORINGTITL 2 THE E2 TO THE HECT DOMAIN.REF MOL.CELL V. 19 297 2005REFN ISSN 1097-2765PMID 16061177DOI 10.1016/J.MOLCEL.2005.06.028 Variant Set Distributions […]
General Structure Information 3iwp CUTC crystal structure of human copper homeostasis protein cutc 2.5Å AUTH Y.LI,J.DU,P.ZHANG,J.DINGTITL CRYSTAL STRUCTURE OF HUMAN COPPER HOMEOSTASISTITL 2 PROTEIN CUTC REVEALS A POTENTIAL COPPER-BINDINGTITL 3 SITEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4edj GORASP2 crystal structure of the grasp55 grasp domain with a phosphomimetic mutation (s189d) 1.9Å AUTH S.T.TRUSCHEL,M.ZHANG,C.BACHERT,M.R.MACBETH,A.D.LINSTEDTTITL ALLOSTERIC REGULATION OF GRASP PROTEIN-DEPENDENT GOLGITITL 2 MEMBRANE TETHERING BY MITOTIC PHOSPHORYLATION.REF J.BIOL.CHEM. V. 287 19870 2012REFN ISSN 0021-9258PMID 22523075DOI 10.1074/JBC.M111.326256 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]