Assessment of Structural Intolerance and Durability
General Structure Information 1nd5 ACPP crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design 2.9Å AUTH E.ORTLUND,M.W.LACOUNT,L.LEBIODATITL CRYSTAL STRUCTURES OF HUMAN PROSTATIC ACID PHOSPHATASE INTITL 2 COMPLEX WITH A PHOSPHATE ION ANDTITL 3 ALPHA-BENZYLAMINOBENZYLPHOSPHONIC ACID UPDATE THETITL […]
General Structure Information 4fpa HK1 crystal structure of recombinant human hexokinase type i mutant d413n glucose 6-phosphate 2.48Å AUTH L.SHEN,Y.GAO,R.B.HONZATKOTITL DETERMINATION OF SITE AFFINITY CONSTANTS FOR PRODUCTTITL 2 INHIBITION OF WILD-TYPE AND MUTANT FORMS OF RECOMBINANTTITL 3 HUMAN HEXOKINASE TYPE IREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3cxl CHN1 crystal structure of human chimerin 1 (chn1) 2.6Å AUTH L.SHEN,M.BUCK,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN CHIMERIN 1 (CHN1).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2acu AKR1B1 tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and the crystal structure of the y48h mutant enzyme 1.76Å AUTH K.M.BOHREN,C.E.GRIMSHAW,C.J.LAI,D.H.HARRISON,AUTH 2 D.RINGE,G.A.PETSKO,K.H.GABBAYTITL TYROSINE-48 IS THE PROTON DONOR AND HISTIDINE-110TITL 2 DIRECTS SUBSTRATE STEREOCHEMICAL SELECTIVITY INTITL 3 THE […]
General Structure Information 4ern ERCC3 crystal structure of the c-terminal domain of human xpb/ercc-3 excision repair protein at 1.80 a 1.8Å AUTH E.HILARIO,Y.LI,Y.NOBUMORI,X.LIU,L.FANTITL STRUCTURE OF THE C-TERMINAL HALF OF HUMAN XPB HELICASE ANDTITL 2 THE IMPACT OF THE DISEASE-CAUSING MUTATION XP11BE.REF ACTA CRYSTALLOGR.,SECT.D V. 69 237 2013REFN ISSN 0907-4449PMID 23385459DOI 10.1107/S0907444912045040 Variant Set Distributions Ripley’s […]
General Structure Information 3thc GLB1 crystal structure of human beta-galactosidase in complex with galactose 1.8Å AUTH U.OHTO,K.USUI,T.OCHI,K.YUKI,Y.SATOW,T.SHIMIZUTITL CRYSTAL STRUCTURE OF HUMAN BETA-GALACTOSIDASE: STRUCTURALTITL 2 BASIS OF GM1 GANGLIOSIDOSIS AND MORQUIO B DISEASESREF J.BIOL.CHEM. V. 287 1801 2012REFN ISSN 0021-9258PMID 22128166DOI 10.1074/JBC.M111.293795 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2vo1 CTPS1 crystal structure of the synthetase domain of human ctp synthetase 2.8Å AUTH P.KURSULA,S.FLODIN,M.EHN,M.HAMMARSTROM,H.SCHULER,P.NORDLUND,AUTH 2 P.STENMARKTITL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE,TITL 2 A TARGET FOR ANTICANCER THERAPY.REF ACTA CRYSTALLOGR.,SECT.F V. 62 613 2006REFN ISSN 1744-3091PMID 16820675DOI 10.1107/S1744309106018136 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3qfc POR crystal structure of human nadph-cytochrome p450 (v492e mutant) 1.8Å AUTH C.XIA,S.P.PANDA,C.C.MAROHNIC,P.MARTASEK,B.S.MASTERS,J.J.KIMTITL STRUCTURAL BASIS FOR HUMAN NADPH-CYTOCHROME P450TITL 2 OXIDOREDUCTASE DEFICIENCY.REF PROC.NATL.ACAD.SCI.USA V. 108 13486 2011REFN ISSN 0027-8424PMID 21808038DOI 10.1073/PNAS.1106632108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1nfb IMPDH2 ternary complex of the human type ii inosine monophosphate dedhydrogenase with 6cl-imp and nad 2.9Å AUTH D.RISAL,M.D.STRICKLER,B.M.GOLDSTEINTITL THE CONFORMATION OF NAD BOUND TO HUMAN INOSINE MONOPHOSPHATETITL 2 DEHYDROGENASE TYPE IIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ni2 EZR structure of the active ferm domain of ezrin 2.3Å AUTH W.J.SMITH,N.NASSAR,A.P.BRETSCHER,R.A.CERIONE,AUTH 2 P.A.KARPLUSTITL STRUCTURE OF THE ACTIVE N-TERMINAL DOMAIN OFTITL 2 EZRIN. CONFORMATIONAL AND MOBILITY CHANGESTITL 3 IDENTIFY KEYSTONE INTERACTIONS.REF J.BIOL.CHEM. V. 278 4949 2003REFN ISSN 0021-9258PMID 12429733DOI 10.1074/JBC.M210601200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]