Assessment of Structural Intolerance and Durability
General Structure Information 3rbn MLH1 crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens] 2.16Å AUTH L.DOMBROVSKY,A.DONG,A.WERNIMONT,P.LOPPNAU,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF MUTL PROTEIN HOMOLOG 1 ISOFORM 1 [HOMOTITL 2 SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dcn ARL1 crystal structure analysis of the arfaptin2 bar domain in complex with arl1 3.01Å AUTH K.NAKAMURA,Z.MAN,Y.XIE,A.HANAI,H.MAKYIO,M.KAWASAKI,R.KATO,AUTH 2 H.-W.SHIN,K.NAKAYAMA,S.WAKATSUKITITL STRUCTURAL BASIS FOR MEMBRANE BINDING SPECIFICITY OF THETITL 2 BIN/AMPHIPHYSIN/RVS (BAR) DOMAIN OF ARFAPTIN-2 DETERMINED BYTITL 3 ARL1 GTPASEREF J.BIOL.CHEM. V. 287 25478 2012REFN ISSN 0021-9258PMID 22679020DOI 10.1074/JBC.M112.365783 Variant Set Distributions Ripley’s K […]
General Structure Information 2jdr AKT2 structure of pkb-beta (akt2) complexed with the inhibitor a- 443654 2.3Å AUTH T.G.DAVIES,M.L.VERDONK,B.GRAHAM,S.SAALAU-BETHELL,AUTH 2 C.C.F.HAMLETT,T.MCHARDY,I.COLLINS,M.D.GARRETT,AUTH 3 P.WORKMAN,S.J.WOODHEAD,H.JHOTI,D.BARFORDTITL A STRUCTURAL COMPARISON OF INHIBITOR BINDING TOTITL 2 PKB, PKA AND PKA-PKB CHIMERAREF J.MOL.BIOL. V. 367 882 2007REFN ISSN 0022-2836PMID 17275837DOI 10.1016/J.JMB.2007.01.004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1h8b ACTN2 ef-hands 3,4 from alpha-actinin / z-repeat 7 from titin -1.0Å AUTH R.A.ATKINSON,C.JOSEPH,G.KELLY,F.W.MUSKETT,AUTH 2 T.A.FRENKIEL,D.NIETLISPACH,A.PASTORETITL CA2+-INDEPENDENT BINDING OF AN EF-HAND DOMAIN TO ATITL 2 NOVEL MOTIF IN THE ALPHA-ACTININ-TITIN COMPLEXREF NAT.STRUCT.BIOL. V. 8 853 2001REFN ISSN 1072-8368PMID 11573089DOI 10.1038/NSB1001-853 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2rnr GTF2H1 solution structure of the complex between tfiie alpha c- terminal acidic domain and tfiih p62 ph domain -1.0Å AUTH M.OKUDA,A.TANAKA,M.SATOH,S.MIZUTA,M.TAKAZAWA,AUTH 2 Y.OHKUMA,Y.NISHIMURATITL STRUCTURAL INSIGHT INTO THE TFIIE-TFIIHTITL 2 INTERACTION: TFIIE AND P53 SHARE THE BINDINGTITL 3 REGION ON TFIIHREF EMBO J. V. 27 1161 2008REFN ISSN 0261-4189PMID 18354501DOI 10.1038/EMBOJ.2008.47 Variant […]
General Structure Information 3fmp NUP214 crystal structure of the nucleoporin nup214 in complex with the dead- box helicase ddx19 3.19Å AUTH J.NAPETSCHNIG,S.A.KASSUBE,E.W.DEBLER,R.W.WONG,G.BLOBEL,AUTH 2 A.HOELZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE INTERACTIONTITL 2 BETWEEN THE NUCLEOPORIN NUP214 AND THE DEAD-BOX HELICASETITL 3 DDX19.REF PROC.NATL.ACAD.SCI.USA V. 106 3089 2009REFN ISSN 0027-8424PMID 19208808DOI 10.1073/PNAS.0813267106 Variant Set Distributions Ripley’s […]
General Structure Information 2dm0 TXK solution structure of the sh2 domain of human tyrosine- protein kinase txk -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH2 DOMAIN OF HUMANTITL 2 TYROSINE-PROTEIN KINASE TXKREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qs9 FLT3 crystal structure of a human flt3 ligand-receptor ternary complex 7.8Å AUTH K.VERSTRAETE,G.VANDRIESSCHE,M.JANUAR,J.ELEGHEERT,AUTH 2 A.V.SHKUMATOV,A.DESFOSSES,K.VAN CRAENENBROECK,D.I.SVERGUN,AUTH 3 I.GUTSCHE,B.VERGAUWEN,S.N.SAVVIDESTITL STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR ASSEMBLY OF THETITL 2 HEMATOPOIETIC FLT3 SIGNALING COMPLEX.REF BLOOD V. 118 60 2011REFN ISSN 0006-4971PMID 21389326DOI 10.1182/BLOOD-2011-01-329532 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4h80 ALDH3A1 crystal structure of human aldh3a1 with its isozyme selective inhibitor – n-[4-(4-methylsulfonyl-2-nitroanilino)phenyl]acetamide 2.5Å AUTH B.PARAJULI,T.GEORGIADIS,M.L.FISHEL,T.D.HURLEYTITL KINETIC AND STRUCTURAL CHARACTERIZATION OF A SELECTIVETITL 2 INHIBITOR FOR HUMAN ALDH3A1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2psr S100A7 human psoriasin (s100a7) ca2+ and zn2+ bound form (crystal form ii) 2.05Å AUTH D.E.BRODERSEN,J.NYBORG,M.KJELDGAARDTITL ZINC-BINDING SITE OF AN S100 PROTEIN REVEALED. TWO CRYSTALTITL 2 STRUCTURES OF CA2+-BOUND HUMAN PSORIASIN (S100A7) IN THETITL 3 ZN2+-LOADED AND ZN2+-FREE STATES.REF BIOCHEMISTRY V. 38 1695 1999REFN ISSN 0006-2960PMID 10026247DOI 10.1021/BI982483D Variant Set Distributions Ripley’s […]