Assessment of Structural Intolerance and Durability
General Structure Information 1g25 MNAT1 solution structure of the n-terminal domain of the human tfiih mat1 subunit -1.0Å AUTH V.GERVAIS,D.BUSSO,E.WASIELEWSKI,A.POTERSZMAN,AUTH 2 J.M.EGLY,J.C.THIERRY,B.KIEFFERTITL SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THETITL 2 HUMAN TFIIH MAT1 SUBUNIT: NEW INSIGHTS INTO THETITL 3 RING FINGER FAMILYREF J.BIOL.CHEM. V. 276 7457 2001REFN ISSN 0021-9258PMID 11056162DOI 10.1074/JBC.M007963200 Variant Set Distributions […]
General Structure Information 4ivo PPOX structure of human protoporphyrinogen ix oxidase(r59q) 2.6Å AUTH B.WANG,X.WEN,X.QIN,Z.WANG,Y.TAN,Y.SHEN,Z.XITITL QUANTITATIVE STRUCTURAL INSIGHT INTO HUMAN VARIEGATETITL 2 PORPHYRIA DISEASE.REF J.BIOL.CHEM. V. 288 11731 2013REFN ISSN 0021-9258PMID 23467411DOI 10.1074/JBC.M113.459768 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1oqy RAD23A structure of the dna repair protein hhr23a -1.0Å AUTH K.J.WALTERS,P.J.LECH,A.M.GOH,Q.WANG,P.M.HOWLEYTITL DNA-REPAIR PROTEIN HHR23A ALTERS ITS PROTEINTITL 2 STRUCTURE UPON BINDING PROTEASOMAL SUBUNIT S5AREF PROC.NATL.ACAD.SCI.USA V. 100 12694 2003REFN ISSN 0027-8424PMID 14557549DOI 10.1073/PNAS.1634989100 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ybx PIP4K2A crystal structure of human phosphatidylinositol-5-phosphate 4-kinase type-2 alpha 2.56Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,S.GRASLUND,AUTH 3 T.KARLBERG,T.KOTENYOVA,E.KOUZNETSOVA,T.NYMAN,C.PERSSON,AUTH 4 H.SCHULER,M.I.SIPONEN,A.G.THORSELL,E.WAHLBERG,J.WEIGELT,AUTH 5 P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN PHOSPHATIDYLINOSITOL-5-TITL 2 PHOSPHATE 4-KINASE TYPE-2 ALPHAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4msv FASLG crystal structure of fasl and dcr3 complex 2.5Å AUTH W.LIU,U.A.RAMAGOPAL,C.ZHAN,J.B.BONANNO,R.C.BHOSLE,AUTH 2 S.G.NATHENSON,S.C.ALMOTITL CRYSTAL STRUCTURE OF FASL AND DCR3 COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1o1v FABP6 human ileal lipid-binding protein (ilbp) in complex with cholyltaurine -1.0Å AUTH M.KURZ,V.BRACHVOGEL,H.MATTER,S.STENGELIN,AUTH 2 H.THUERING,W.KRAMERTITL INSIGHTS INTO THE BILE ACID TRANSPORTATION SYSTEM:TITL 2 THE HUMAN ILEAL LIPID-BINDINGTITL 3 PROTEIN-CHOLYLTAURINE COMPLEX AND ITS COMPARISONTITL 4 WITH HOMOLOGOUS STRUCTURES.REF PROTEINS V. 50 312 2003REFN ISSN 0887-3585PMID 12486725DOI 10.1002/PROT.10289 Variant Set Distributions Ripley’s K […]
General Structure Information 2w5a NEK2 human nek2 kinase adp-bound 1.55Å AUTH I.WESTWOOD,D.M.CHEARY,J.E.BAXTER,M.W.RICHARDS,AUTH 2 R.L.VAN MONTFORT,A.M.FRY,R.BAYLISSTITL INSIGHTS INTO THE CONFORMATIONAL VARIABILITY ANDTITL 2 REGULATION OF HUMAN NEK2 KINASE.REF J.MOL.BIOL. V. 386 476 2009REFN ISSN 0022-2836PMID 19124027DOI 10.1016/J.JMB.2008.12.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4f7s CDK8 crystal structure of human cdk8/cycc in the dmg-in conformation 2.2Å AUTH E.V.SCHNEIDER,J.BOTTCHER,R.HUBER,K.MASKOS,L.NEUMANNTITL STRUCTURE-KINETIC RELATIONSHIP STUDY OF CDK8/CYCC SPECIFICTITL 2 COMPOUNDS.REF PROC.NATL.ACAD.SCI.USA V. 110 8081 2013REFN ISSN 0027-8424PMID 23630251DOI 10.1073/PNAS.1305378110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1t77 LRBA crystal structure of the ph-beach domains of human lrba/bgl 2.4Å AUTH D.GEBAUER,J.LI,G.JOGL,Y.SHEN,D.G.MYSZKA,L.TONGTITL CRYSTAL STRUCTURE OF THE PH-BEACH DOMAINS OF HUMANTITL 2 LRBA/BGLREF BIOCHEMISTRY V. 43 14873 2004REFN ISSN 0006-2960PMID 15554694DOI 10.1021/BI049498Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lwk CRYBA4 crystal structure of human beta-crystallin a4 (cryba4) 1.7Å AUTH A.CHAIKUAD,N.SHAFQAT,T.KROJER,W.W.YUE,R.COCKING,M.VOLLMAR,AUTH 2 J.R.C.MUNIZ,A.C.W.PIKE,F.VON DELFT,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA-CRYSTALLIN A4 (CRYBA4)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants