Assessment of Structural Intolerance and Durability
General Structure Information 3pjc JAK3 crystal structure of jak3 complexed with a potent atp site inhibitor showing high selectivity within the janus kinase family 2.2Å AUTH G.THOMA,F.NUNINGER,R.FALCHETTO,E.HERMES,G.A.TAVARES,AUTH 2 E.VANGREVELINGHE,H.G.ZERWESTITL IDENTIFICATION OF A POTENT JANUS KINASE 3 INHIBITOR WITHTITL 2 HIGH SELECTIVITY WITHIN THE JANUS KINASE FAMILY.REF J.MED.CHEM. V. 54 284 2011REFN ISSN 0022-2623PMID 21155605DOI 10.1021/JM101157Q […]
General Structure Information 3f81 DUSP3 interaction of vhr with sa3 1.9Å AUTH S.WU,S.VOSSIUS,S.RAHMOUNI,A.V.MILETIC,T.VANG,AUTH 2 J.VAZQUEZ-RODRIGUEZ,F.CERIGNOLI,Y.ARIMURA,AUTH 3 S.WILLIAMS,T.HAYES,M.MOUTSCHEN,S.VASILE,AUTH 4 M.PELLECCHIA,T.MUSTELIN,L.TAUTZTITL MULTIDENTATE SMALL-MOLECULE INHIBITORS OF VACCINIATITL 2 H1-RELATED (VHR) PHOSPHATASE DECREASE PROLIFERATIONTITL 3 OF CERVIX CANCER CELLS.REF J.MED.CHEM. V. 52 6716 2009REFN ISSN 0022-2623PMID 19888758DOI 10.1021/JM901016K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2y25 MYOM1 crystal structure of the myomesin domains my11-my13 3.5Å AUTH N.PINOTSIS,S.D.CHATZIEFTHIMIOU,F.BERKEMEIER,F.BEURON,AUTH 2 I.M.MAVRIDIS,P.V.KONAREV,D.I.SVERGUN,E.MORRIS,M.RIEF,AUTH 3 M.WILMANNSTITL SUPERHELICAL ARCHITECTURE OF THE MYOSIN FILAMENT-LINKINGTITL 2 PROTEIN MYOMESIN WITH UNUSUAL ELASTIC PROPERTIES.REF PLOS BIOL. V. 10 1261 2012REFN ISSN 1544-9173PMID 22347812DOI 10.1371/JOURNAL.PBIO.1001261 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3vbb SARS crystal structure of seryl-trna synthetase from human at 2.9 angstroms 2.89Å AUTH X.XU,Y.SHI,H.M.ZHANG,E.C.SWINDELL,A.G.MARSHALL,M.GUO,AUTH 2 S.KISHI,X.L.YANGTITL UNIQUE DOMAIN APPENDED TO VERTEBRATE TRNA SYNTHETASE ISTITL 2 ESSENTIAL FOR VASCULAR DEVELOPMENT.REF NAT COMMUN V. 3 681 2012REFN ESSN 2041-1723PMID 22353712DOI 10.1038/NCOMMS1686 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1s31 TUB crystal structure analysis of the human tub protein (isoform a) spanning residues 289 through 561 2.7Å AUTH S.BOUTBOUL,K.J.CARROLL,A.BASDEVANT,C.GOMEZ,E.NANDROT,AUTH 2 K.CLEMENT,L.SHAPIRO,M.ABITBOLTITL A NOVEL HUMAN OBESITY AND SENSORY DEFICIT SYNDROME RESULTINGTITL 2 FROM A MUTATION IN THE TUB GENEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4b18 KPNA1 the crystal structure of human importin alpha 5 with tert nls peptide 2.52Å AUTH S.A.JEONG,K.KIM,J.H.LEE,J.S.CHA,P.KHADKA,H.CHO,I.K.CHUNGTITL AKT-MEDIATED PHOSPHORYLATION INCREASES THE BINDING AFFINITYTITL 2 OF HTERT FOR IMPORTIN ALPHA TO PROMOTE NUCLEARTITL 3 TRANSLOCATION.REF J.CELL.SCI. V. 128 2287 2015REFN ISSN 0021-9533PMID 25999477DOI 10.1242/JCS.166132 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1oki CRYBB1 crystal structure of truncated human beta-b1-crystallin 1.4Å AUTH R.L.M.VAN MONTFORT,O.A.BATEMAN,N.H.LUBSEN,AUTH 2 C.SLINGSBYTITL CRYSTAL STRUCTURE OF TRUNCATED HUMANTITL 2 BETA-B1-CRYSTALLINREF PROTEIN SCI. V. 12 2606 2003REFN ISSN 0961-8368PMID 14573871DOI 10.1110/PS.03265903 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3sog AMPH crystal structure of the bar domain of human amphiphysin, isoform 1 2.3Å Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ppl PNLIPRP1 human pancreatic lipase-related protein 1 2.2Å AUTH J.R.WALKER,T.DAVIS,A.SEITOVA,C.BUTLER-COLE,AUTH 2 J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE HUMAN PANCREATIC LIPASE-RELATEDTITL 2 PROTEIN 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cjz PTPN5 crystal structure of the c472s mutant of human protein tyrosine phosphatase ptpn5 (step, striatum enriched phosphatase) in complex with phosphotyrosine 1.7Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K […]