Assessment of Structural Intolerance and Durability
General Structure Information 2eb1 DICER1 crystal structure of the c-terminal rnase iii domain of human dicer 2.0Å AUTH D.TAKESHITA,S.ZENNO,W.C.LEE,K.NAGATA,K.SAIGO,M.TANOKURATITL HOMODIMERIC STRUCTURE AND DOUBLE-STRANDED RNA CLEAVAGETITL 2 ACTIVITY OF THE C-TERMINAL RNASE III DOMAIN OF HUMAN DICERREF J.MOL.BIOL. V. 374 106 2007REFN ISSN 0022-2836PMID 17920623DOI 10.1016/J.JMB.2007.08.069 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2ovq FBXW7 structure of the skp1-fbw7-cyclinedegc complex 2.6Å AUTH B.HAO,S.OEHLMANN,M.E.SOWA,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF A FBW7-SKP1-CYCLIN E COMPLEX:TITL 2 MULTISITE-PHOSPHORYLATED SUBSTRATE RECOGNITION BY SCFTITL 3 UBIQUITIN LIGASESREF MOL.CELL V. 26 131 2007REFN ISSN 1097-2765PMID 17434132DOI 10.1016/J.MOLCEL.2007.02.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4nm6 TET2 crystal structure of tet2-dna complex 2.03Å AUTH L.HU,Z.LI,J.CHENG,Q.RAO,W.GONG,M.LIU,Y.G.SHI,J.ZHU,P.WANG,AUTH 2 Y.XUTITL CRYSTAL STRUCTURE OF TET2-DNA COMPLEX: INSIGHT INTOTITL 2 TET-MEDIATED 5MC OXIDATION.REF CELL(CAMBRIDGE,MASS.) V. 155 1545 2013REFN ISSN 0092-8674PMID 24315485DOI 10.1016/J.CELL.2013.11.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bhw EP300 structural basis for autoinhibition of the acetyltransferase activity of p300 2.8Å AUTH M.DELVECCHIO,J.GAUCHER,C.AGUILAR-GURRIERI,E.ORTEGA,D.PANNETITL STRUCTURE OF THE P300 CATALYTIC CORE AND IMPLICATIONS FORTITL 2 CHROMATIN TARGETING AND HAT REGULATIONREF NAT.STRUCT.MOL.BIOL. V. 20 1040 2013REFN ISSN 1545-9993PMID 23934153DOI 10.1038/NSMB.2642 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2shp PTPN11 tyrosine phosphatase shp-2 2.0Å AUTH P.HOF,S.PLUSKEY,S.DHE-PAGANON,M.J.ECK,S.E.SHOELSONTITL CRYSTAL STRUCTURE OF THE TYROSINE PHOSPHATASETITL 2 SHP-2.REF CELL(CAMBRIDGE,MASS.) V. 92 441 1998REFN ISSN 0092-8674PMID 9491886DOI 10.1016/S0092-8674(00)80938-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bhw EP300 structural basis for autoinhibition of the acetyltransferase activity of p300 2.8Å AUTH M.DELVECCHIO,J.GAUCHER,C.AGUILAR-GURRIERI,E.ORTEGA,D.PANNETITL STRUCTURE OF THE P300 CATALYTIC CORE AND IMPLICATIONS FORTITL 2 CHROMATIN TARGETING AND HAT REGULATIONREF NAT.STRUCT.MOL.BIOL. V. 20 1040 2013REFN ISSN 1545-9993PMID 23934153DOI 10.1038/NSMB.2642 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2shp PTPN11 tyrosine phosphatase shp-2 2.0Å AUTH P.HOF,S.PLUSKEY,S.DHE-PAGANON,M.J.ECK,S.E.SHOELSONTITL CRYSTAL STRUCTURE OF THE TYROSINE PHOSPHATASETITL 2 SHP-2.REF CELL(CAMBRIDGE,MASS.) V. 92 441 1998REFN ISSN 0092-8674PMID 9491886DOI 10.1016/S0092-8674(00)80938-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1d5r PTEN crystal structure of the pten tumor suppressor 2.1Å AUTH J.O.LEE,H.YANG,M.M.GEORGESCU,A.DI CRISTOFANO,AUTH 2 T.MAEHAMA,Y.SHI,J.E.DIXON,P.PANDOLFI,N.P.PAVLETICHTITL CRYSTAL STRUCTURE OF THE PTEN TUMOR SUPPRESSOR:TITL 2 IMPLICATIONS FOR ITS PHOSPHOINOSITIDE PHOSPHATASETITL 3 ACTIVITY AND MEMBRANE ASSOCIATION.REF CELL(CAMBRIDGE,MASS.) V. 99 323 1999REFN ISSN 0092-8674PMID 10555148DOI 10.1016/S0092-8674(00)81663-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3eto NOTCH1 2 angstrom xray structure of the notch1 negative regulatory region (nrr) 2.0Å AUTH W.R.GORDON,M.ROY,D.VARDAR-ULU,M.GARFINKEL,M.R.MANSOUR,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURE OF THE NOTCH1-NEGATIVE REGULATORY REGION:TITL 2 IMPLICATIONS FOR NORMAL ACTIVATION AND PATHOGENIC SIGNALINGTITL 3 IN T-ALL.REF BLOOD V. 113 4381 2009REFN ISSN 0006-4971PMID 19075186DOI 10.1182/BLOOD-2008-08-174748 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2rd0 PIK3CA structure of a human p110alpha/p85alpha complex 3.05Å AUTH C.H.HUANG,D.MANDELKER,O.SCHMIDT-KITTLER,Y.SAMUELS,AUTH 2 V.E.VELCULESCU,K.W.KINZLER,B.VOGELSTEIN,S.B.GABELLI,AUTH 3 L.M.AMZELTITL THE STRUCTURE OF A HUMAN P110ALPHA/P85ALPHA COMPLEXTITL 2 ELUCIDATES THE EFFECTS OF ONCOGENIC PI3KALPHA MUTATIONS.REF SCIENCE V. 318 1744 2007REFN ISSN 0036-8075PMID 18079394DOI 10.1126/SCIENCE.1150799 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants