Assessment of Structural Intolerance and Durability
General Structure Information 4hc4 PRMT6 human hmt1 hnrnp methyltransferase-like protein 6 (s. cerevisiae) 1.97Å AUTH H.ZENG,A.DONG,H.HE,M.EL BAKKOURI,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,H.WUTITL THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNPTITL 2 METHYLTRANSFERASE-LIKE PROTEIN 6 IN COMPLEX WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2a5j RAB2B crystal structure of human rab2b 1.5Å AUTH J.WANG,A.DONG,Y.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.W.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB2BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1z4r KAT2A human gcn5 acetyltransferase 1.74Å AUTH A.SCHUETZ,G.BERNSTEIN,A.DONG,T.ANTOSHENKO,H.WU,AUTH 2 P.LOPPNAU,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF A BINARY COMPLEX BETWEENTITL 2 HUMAN GCN5 HISTONE ACETYLTRANSFERASE DOMAIN ANDTITL 3 ACETYL COENZYME AREF PROTEINS V. 68 403 2007REFN ISSN 0887-3585PMID 17410582DOI 10.1002/PROT.21407 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rex RND1 crystal structure of the effector domain of plxnb1 bound with rnd1 gtpase 2.3Å AUTH Y.TONG,W.TEMPEL,L.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PLXNB1 BOUNDTITL 2 WITH RND1 GTPASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f70 L3MBTL2 crystal structure of l3mbtl2-h4k20me1 complex 2.1Å AUTH Y.GUO,N.NADY,C.QI,A.ALLALI-HASSANI,H.ZHU,P.PAN,AUTH 2 M.A.ADAMS-CIOABA,M.F.AMAYA,A.DONG,M.VEDADI,M.SCHAPIRA,AUTH 3 R.J.READ,C.H.ARROWSMITH,J.MINTITL METHYLATION-STATE-SPECIFIC RECOGNITION OF HISTONES BY THETITL 2 MBT REPEAT PROTEIN L3MBTL2.REF NUCLEIC ACIDS RES. V. 37 2204 2009REFN ISSN 0305-1048PMID 19233876DOI 10.1093/NAR/GKP086 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3mxo PGAM5 crystal structure oh human phosphoglycerate mutase family member 5 (pgam5) 1.7Å AUTH A.CHAIKUAD,I.ALFANO,S.PICAUD,P.FILIPPAKOPOULOS,A.BARR,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 3 K.TAKEDA,H.ICHIJO,S.KNAPPTITL CRYSTAL STRUCTURE OH HUMAN PHOSPHOGLYCERATE MUTASE FAMILYTITL 2 MEMBER 5 (PGAM5)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3cou NUDT16 crystal structure of human nudix motif 16 (nudt16) 1.8Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 5 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,AUTH 6 T.NYMAN,C.PERSSON,J.SAGEMARK,H.SCHUELER,L.SVENSSON,AUTH 7 A.G.THORSELL,S.VAN DEN BERG,M.WELIN,J.WEIGELT,AUTH 8 M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN NUDIX MOTIF 16 (NUDT16).REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2p82 ATG4A cysteine protease atg4a 2.1Å AUTH J.R.WALKER,T.DAVIS,S.MUJIB,C.BUTLER-COLE,P.J.FINERTY JR.,AUTH 2 J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL HUMAN CYSTEINE PROTEASE ATG4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1y6l UBE2E2 human ubiquitin conjugating enzyme e2e2 1.85Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 3s8i DDI1 the retroviral-like protease (rvp) domain of human ddi1 1.7Å AUTH J.R.WALKER,A.ASINAS,A.DONG,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,S.DHE-PAGANON,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL RETROPEPSIN-LIKE DOMAIN OF HUMAN DDI1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants