Assessment of Structural Intolerance and Durability
General Structure Information 1i3d HBG1 human carbonmonoxy hemoglobin barts (gamma4) 1.7Å AUTH R.D.KIDD,H.M.BAKER,A.J.MATHEWS,T.BRITTAIN,E.N.BAKERTITL OLIGOMERIZATION AND LIGAND BINDING IN ATITL 2 HOMOTETRAMERIC HEMOGLOBIN: TWO HIGH-RESOLUTIONTITL 3 CRYSTAL STRUCTURES OF HEMOGLOBIN BARTSTITL 4 (GAMMA(4)), A MARKER FOR ALPHA-THALASSEMIA.REF PROTEIN SCI. V. 10 1739 2001REFN ISSN 0961-8368PMID 11514664DOI 10.1110/PS.11701 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1vtn FOXA3 co-crystal structure of the hnf-3/fork head dna-recognition motif resembles histone h5 2.5Å AUTH K.L.CLARK,E.D.HALAY,E.LAI,S.K.BURLEYTITL CO-CRYSTAL STRUCTURE OF THE HNF-3/FORK HEAD DNA-RECOGNITIONTITL 2 MOTIF RESEMBLES HISTONE H5REF NATURE V. 364 412 1993REFN ISSN 0028-0836PMID 8332212DOI 10.1038/364412A0 Variant Set Distributions Mapped Variants
General Structure Information 2ain MLLT4 solution structure of the af-6 pdz domain complexed with the c-terminal peptide from the bcr protein -1.0Å AUTH Q.CHEN,X.NIU,Y.XU,J.WU,Y.SHITITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THETITL 2 AF-6 PDZ DOMAIN/BCR PEPTIDE COMPLEX.REF PROTEIN SCI. V. 16 1053 2007REFN ISSN 0961-8368PMID 17473018DOI 10.1110/PS.062440607 Variant Set Distributions Mapped Variants
General Structure Information 1vol GTF2B tfiib (human core domain)/tbp (a.thaliana)/tata element ternary complex 2.7Å AUTH D.B.NIKOLOV,H.CHEN,E.D.HALAY,A.A.USHEVA,K.HISATAKE,AUTH 2 D.K.LEE,R.G.ROEDER,S.K.BURLEYTITL CRYSTAL STRUCTURE OF A TFIIB-TBP-TATA-ELEMENTTITL 2 TERNARY COMPLEX.REF NATURE V. 377 119 1995REFN ISSN 0028-0836PMID 7675079DOI 10.1038/377119A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3sf4 GPSM2 crystal structure of the complex between the conserved cell polarity proteins inscuteable and lgn 2.6Å AUTH S.YUZAWA,S.KAMAKURA,Y.IWAKIRI,J.HAYASE,H.SUMIMOTOTITL STRUCTURAL BASIS FOR INTERACTION BETWEEN THE CONSERVED CELLTITL 2 POLARITY PROTEINS INSCUTEABLE AND LEU-GLY-ASNTITL 3 REPEAT-ENRICHED PROTEIN (LGN)REF PROC.NATL.ACAD.SCI.USA V. 108 19210 2011REFN ISSN 0027-8424PMID 22074847DOI 10.1073/PNAS.1110951108 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4js0 CDC42 complex of cdc42 with the crib-pr domain of irsp53 1.9Å AUTH D.J.KAST,C.YANG,A.DISANZA,M.BOCZKOWSKA,Y.MADASU,G.SCITA,AUTH 2 T.SVITKINA,R.DOMINGUEZTITL MECHANISM OF IRSP53 INHIBITION AND COMBINATORIAL ACTIVATIONTITL 2 BY CDC42 AND DOWNSTREAM EFFECTORS.REF NAT.STRUCT.MOL.BIOL. V. 21 413 2014REFN ISSN 1545-9993PMID 24584464DOI 10.1038/NSMB.2781 Variant Set Distributions Mapped Variants
General Structure Information 2nlw EIF3B solution structure of the rrm domain of human eukaryotic initiation factor 3b -1.0Å AUTH L.ELANTAK,A.G.TZAKOS,N.LOCKER,P.J.LUKAVSKYTITL STRUCTURE OF EIF3B RNA RECOGNITION MOTIF AND ITSTITL 2 INTERACTION WITH EIF3J: STRUCTURAL INSIGHTS INTOTITL 3 THE RECRUITMENT OF EIF3B TO THE 40 S RIBOSOMALTITL 4 SUBUNIT.REF J.BIOL.CHEM. V. 282 8165 2007REFN ISSN 0021-9258PMID 17190833DOI […]
General Structure Information 3u9c CSNK2A1 structure of a c-terminal deletion mutant of human protein kinase ck2 catalytic subunit with the atp-competitive inhibitor resorufin 3.2Å AUTH K.KLOPFFLEISCH,O.G.ISSINGER,K.NIEFINDTITL LOW-DENSITY CRYSTAL PACKING OF HUMAN PROTEIN KINASE CK2TITL 2 CATALYTIC SUBUNIT IN COMPLEX WITH RESORUFIN OR OTHERTITL 3 LIGANDS: A TOOL TO STUDY THE UNIQUE HINGE-REGION PLASTICITYTITL 4 OF […]
General Structure Information 1iyj SHFM1 structure of a brca2-dss1 complex 3.4Å AUTH H.YANG,P.D.JEFFREY,J.MILLER,E.KINNUCAN,Y.SUN,AUTH 2 N.H.THOMA,N.ZHENG,P.L.CHEN,W.H.LEE,N.P.PAVLETICHTITL BRCA2 FUNCTION IN DNA BINDING AND RECOMBINATIONTITL 2 FROM A BRCA2-DSS1-SSDNA STRUCTURE.REF SCIENCE V. 297 1837 2002REFN ISSN 0036-8075PMID 12228710DOI 10.1126/SCIENCE.297.5588.1837 Variant Set Distributions Mapped Variants
General Structure Information 1k93 CALM3 crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 2.95Å AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A Variant Set Distributions Ripley’s K Analysis Plots […]