Assessment of Structural Intolerance and Durability
General Structure Information 3u7u ERBB4 crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta 3.03Å AUTH P.LIU,T.E.CLEVELAND,S.BOUYAIN,P.O.BYRNE,P.A.LONGO,D.J.LEAHYTITL A SINGLE LIGAND IS SUFFICIENT TO ACTIVATE EGFR DIMERS.REF PROC.NATL.ACAD.SCI.USA V. 109 10861 2012REFN ISSN 0027-8424PMID 22699492DOI 10.1073/PNAS.1201114109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3u3f PTK2B structural basis for the interaction of pyk2 pat domain with paxillin ld motifs 3.1Å AUTH M.S.VANAROTTI,D.J.MILLER,C.D.GUIBAO,A.NOURSE,J.J.ZHENGTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO THE INTERACTIONTITL 2 BETWEEN PYK2 AND PAXILLIN LD MOTIFS.REF J.MOL.BIOL. V. 426 3985 2014REFN ISSN 0022-2836PMID 25174335DOI 10.1016/J.JMB.2014.08.014 Variant Set Distributions Mapped Variants
General Structure Information 4awl NFYC the nf-y transcription factor is structurally and functionally a sequence specific histone 3.08Å AUTH M.NARDINI,N.GNESUTTA,G.DONATI,R.GATTA,C.FORNI,A.FOSSATI,AUTH 2 C.VONRHEIN,D.MORAS,C.ROMIER,M.BOLOGNESI,R.MANTOVANITITL SEQUENCE-SPECIFIC TRANSCRIPTION FACTOR NF-Y DISPLAYSTITL 2 HISTONE-LIKE DNA BINDING AND H2B-LIKE UBIQUITINATION.REF CELL(CAMBRIDGE,MASS.) V. 152 132 2013REFN ISSN 0092-8674PMID 23332751DOI 10.1016/J.CELL.2012.11.047 Variant Set Distributions Mapped Variants
General Structure Information 3q0n PUM1 crystal structure of the pumilio-homology domain from human pumilio1 in complex with erk2 nre 2.4Å AUTH G.LU,T.M.HALLTITL ALTERNATE MODES OF COGNATE RNA RECOGNITION BY HUMAN PUMILIOTITL 2 PROTEINS.REF STRUCTURE V. 19 361 2011REFN ISSN 0969-2126PMID 21397187DOI 10.1016/J.STR.2010.12.019 Variant Set Distributions Mapped Variants
General Structure Information 3q0n PUM1 crystal structure of the pumilio-homology domain from human pumilio1 in complex with erk2 nre 2.4Å AUTH G.LU,T.M.HALLTITL ALTERNATE MODES OF COGNATE RNA RECOGNITION BY HUMAN PUMILIOTITL 2 PROTEINS.REF STRUCTURE V. 19 361 2011REFN ISSN 0969-2126PMID 21397187DOI 10.1016/J.STR.2010.12.019 Variant Set Distributions Mapped Variants
General Structure Information 3q0n PUM1 crystal structure of the pumilio-homology domain from human pumilio1 in complex with erk2 nre 2.4Å AUTH G.LU,T.M.HALLTITL ALTERNATE MODES OF COGNATE RNA RECOGNITION BY HUMAN PUMILIOTITL 2 PROTEINS.REF STRUCTURE V. 19 361 2011REFN ISSN 0969-2126PMID 21397187DOI 10.1016/J.STR.2010.12.019 Variant Set Distributions Mapped Variants
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]