Assessment of Structural Intolerance and Durability
General Structure Information 1jh4 PAIP1 solution structure of the c-terminal pabc domain of human poly(a)-binding protein in complex with the peptide from paip1 -1.0Å AUTH G.KOZLOV,G.DE CRESCENZO,N.S.LIM,N.SIDDIQUI,AUTH 2 D.FANTUS,A.KAHVEJIAN,J.F.TREMPE,D.ELIAS,I.EKIEL,AUTH 3 N.SONENBERG,M.OCONNOR-MCCOURT,K.GEHRINGTITL STRUCTURAL BASIS OF LIGAND RECOGNITION BY PABC, ATITL 2 HIGHLY SPECIFIC PEPTIDE-BINDING DOMAIN FOUND INTITL 3 POLY(A)-BINDING PROTEIN AND A HECT UBIQUITIN LIGASEREF EMBO […]
General Structure Information 3jw0 NEDD4L e2~ubiquitin-hect 3.1Å AUTH H.B.KAMADURAI,J.SOUPHRON,D.C.SCOTT,D.M.DUDA,D.J.MILLER,AUTH 2 D.STRINGER,R.C.PIPER,B.A.SCHULMANTITL INSIGHTS INTO UBIQUITIN TRANSFER CASCADES FROM A STRUCTURETITL 2 OF A UBCH5B APPROXIMATELY UBIQUITIN-HECT(NEDD4L) COMPLEX.REF MOL.CELL V. 36 1095 2009REFN ISSN 1097-2765PMID 20064473DOI 10.1016/J.MOLCEL.2009.11.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zv2 CAMKK2 crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, camkk2 kinase domain in complex with sto-609 2.4Å AUTH M.KUKIMOTO-NIINO,S.YOSHIKAWA,T.TAKAGI,N.OHSAWA,Y.TOMABECHI,AUTH 2 T.TERADA,M.SHIROUZU,A.SUZUKI,S.LEE,T.YAMAUCHI,M.OKADA-IWABU,AUTH 3 M.IWABU,T.KADOWAKI,Y.MINOKOSHI,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE CA2+/CALMODULIN-DEPENDENT PROTEINTITL 2 KINASE KINASE IN COMPLEX WITH THE INHIBITOR STO-609REF J.BIOL.CHEM. V. 286 22570 2011REFN ISSN 0021-9258PMID 21504895DOI 10.1074/JBC.M111.251710 Variant Set […]
General Structure Information 2p0f ARHGAP9 arhgap9 ph domain in complex with ins(1,3,5)p3 1.91Å AUTH D.F.CECCARELLI,I.M.BLASUTIG,M.GOUDREAULT,Z.LI,AUTH 2 J.RUSTON,T.PAWSON,F.SICHERITITL NON-CANONICAL INTERACTION OF PHOSPHOINOSITIDESTITL 2 WITH PLECKSTRIN HOMOLOGY DOMAINS OF TIAM1 ANDTITL 3 ARHGAP9.REF J.BIOL.CHEM. V. 282 13864 2007REFN ISSN 0021-9258PMID 17339315DOI 10.1074/JBC.M700505200 Variant Set Distributions Mapped Variants
General Structure Information 3f6k SORT1 crystal structure of the vps10p domain of human sortilin/nts3 in complex with neurotensin 2.0Å AUTH E.M.QUISTGAARD,P.MADSEN,M.K.GROFTEHAUGE,P.NISSEN,AUTH 2 C.M.PETERSEN,S.S.THIRUPTITL LIGANDS BIND TO SORTILIN IN THE TUNNEL OF A TEN-BLADEDTITL 2 BETA-PROPELLER DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 16 96 2009REFN ISSN 1545-9993PMID 19122660DOI 10.1038/NSMB.1543 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1r8u CITED2 nmr structure of cbp taz1/cited2 complex -1.0Å AUTH R.N.DE GUZMAN,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL INTERACTION OF THE TAZ1 DOMAIN OF THE CREB-BINDINGTITL 2 PROTEIN WITH THE ACTIVATION DOMAIN OF CITED2:TITL 3 REGULATION BY COMPETITION BETWEEN INTRINSICALLYTITL 4 UNSTRUCTURED LIGANDS FOR NON-IDENTICAL BINDINGTITL 5 SITES.REF J.BIOL.CHEM. V. 279 3042 2004REFN ISSN 0021-9258PMID 14594809DOI […]
General Structure Information 2le9 S100A13 ragec2-s100a13 tetrameric complex -1.0Å AUTH S.G.RANI,S.K.MOHAN,C.YUTITL INTERACTION OF S100A13 WITH RECEPTOR FOR ADVANCED GLYCATIONTITL 2 END PRODUCTS (RAGE) C2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4gqb WDR77 crystal structure of the human prmt5:mep50 complex 2.06Å AUTH S.ANTONYSAMY,Z.BONDAY,R.M.CAMPBELL,B.DOYLE,Z.DRUZINA,AUTH 2 T.GHEYI,B.HAN,L.N.JUNGHEIM,Y.QIAN,C.RAUCH,M.RUSSELL,AUTH 3 J.M.SAUDER,S.R.WASSERMAN,K.WEICHERT,F.S.WILLARD,A.ZHANG,AUTH 4 S.EMTAGETITL CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 17960 2012REFN ISSN 0027-8424PMID 23071334DOI 10.1073/PNAS.1209814109 Variant Set Distributions Mapped Variants
General Structure Information 4aj5 SKA2 crystal structure of the ska core complex 3.32Å AUTH A.A.JEYAPRAKASH,A.SANTAMARIA,U.JAYACHANDRAN,Y.W.CHAN,AUTH 2 C.BENDA,E.A.NIGG,E.CONTITITL STRUCTURAL AND FUNCTIONAL ORGANIZATION OF THE SKA COMPLEX,TITL 2 A KEY COMPONENT OF THE KINETOCHORE-MICROTUBULE INTERFACE.REF MOL.CELL V. 46 274 2012REFN ISSN 1097-2765PMID 22483620DOI 10.1016/J.MOLCEL.2012.03.005 Variant Set Distributions Mapped Variants
General Structure Information 4llb KAT6A crystal structure of moz double phd finger histone h3k14ac complex 2.5Å AUTH I.DREVENY,S.E.DEEVES,J.FULTON,B.YUE,M.MESSMER,AUTH 2 A.BHATTACHARYA,H.M.COLLINS,D.M.HEERYTITL THE DOUBLE PHD FINGER DOMAIN OF MOZ/MYST3 INDUCESTITL 2 ALPHA-HELICAL STRUCTURE OF THE HISTONE H3 TAIL TO FACILITATETITL 3 ACETYLATION AND METHYLATION SAMPLING AND MODIFICATION.REF NUCLEIC ACIDS RES. V. 42 822 2014REFN ISSN 0305-1048PMID 24150941DOI […]