Assessment of Structural Intolerance and Durability
General Structure Information 2wtk STK11 structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex 2.65Å AUTH E.ZEQIRAJ,B.M.FILIPPI,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE LKB1-STRAD-MO25 COMPLEX REVEALS ANTITL 2 ALLOSTERIC MECHANISM OF KINASE ACTIVATION.REF SCIENCE V. 326 1707 2009REFN ISSN 0036-8075PMID 19892943DOI 10.1126/SCIENCE.1178377 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1de4 HFE hemochromatosis protein hfe complexed with transferrin receptor 2.8Å AUTH M.J.BENNETT,J.A.LEBRON,P.J.BJORKMANTITL CRYSTAL STRUCTURE OF THE HEREDITARY HAEMOCHROMATOSIS PROTEINTITL 2 HFE COMPLEXED WITH TRANSFERRIN RECEPTOR.REF NATURE V. 403 46 2000REFN ISSN 0028-0836PMID 10638746DOI 10.1038/47417 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4kit PRPF8 crystal structure of human brr2 in complex with the prp8 jab1/mpn domain 3.6Å AUTH S.MOZAFFARI-JOVIN,T.WANDERSLEBEN,K.F.SANTOS,C.L.WILL,AUTH 2 R.LUHRMANN,M.C.WAHLTITL INHIBITION OF RNA HELICASE BRR2 BY THE C-TERMINAL TAIL OFTITL 2 THE SPLICEOSOMAL PROTEIN PRP8.REF SCIENCE V. 341 80 2013REFN ISSN 0036-8075PMID 23704370DOI 10.1126/SCIENCE.1237515 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ocp DGUOK crystal structure of human deoxyguanosine kinase 2.8Å AUTH K.JOHANSSON,S.RAMASWAMY,C.LJUNGKRANTZ,W.KNECHT,AUTH 2 J.PISKUR,B.MUNCH-PETERSEN,S.ERIKSSON,H.EKLUNDTITL STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITIES OFTITL 2 CELLULAR DEOXYRIBONUCLEOSIDE KINASES.REF NAT.STRUCT.BIOL. V. 8 616 2001REFN ISSN 1072-8368PMID 11427893DOI 10.1038/89661 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1gxe MYBPC3 central domain of cardiac myosin binding protein c -1.0Å AUTH S.IDOWU,M.GAUTEL,S.PERKINS,M.PFUHLTITL STRUCTURE, STABILITY AND DYNAMICS OF THE CENTRALTITL 2 DOMAIN OF CARDIAC MYOSIN BINDING PROTEIN CTITL 3 (MYBP-C): IMPLICATIONS FOR MULTIDOMAIN ASSEMBLYTITL 4 AND CAUSES FOR CARDIOMYOPATHYREF J.MOL.BIOL. V. 329 745 2003REFN ISSN 0022-2836PMID 12787675DOI 10.1016/S0022-2836(03)00425-X Variant Set Distributions Ripley’s […]
General Structure Information 3g2f BMPR2 crystal structure of the kinase domain of bone morphogenetic protein receptor type ii (bmpr2) at 2.35 a resolution 2.35Å TITL CRYSTAL STRUCTURE OF THE BMPR2 KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yqg DSG2 solution structure of the first cadherin domain from human desmoglein-2 -1.0Å AUTH R.SANO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST CADHERIN DOMAINTITL 2 FROM HUMAN DESMOGLEIN-2REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4mq2 DYRK1A the crystal structure of dyrk1a with a bound pyrido[2,3-d]pyrimidine inhibitor 2.8Å AUTH K.ANDERSON,Y.CHEN,Z.CHEN,R.DOMINIQUE,K.GLENN,Y.HE,C.JANSON,AUTH 2 K.C.LUK,C.LUKACS,A.POLONSKAIA,Q.QIAO,A.RAILKAR,P.ROSSMAN,AUTH 3 H.SUN,Q.XIANG,M.VILENCHIK,P.WOVKULICH,X.ZHANGTITL PYRIDO[2,3-D]PYRIMIDINES: DISCOVERY AND PRELIMINARY SAR OF ATITL 2 NOVEL SERIES OF DYRK1B AND DYRK1A INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 6610 2013REFN ISSN 0960-894XPMID 24239188DOI 10.1016/J.BMCL.2013.10.055 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3m1n SHH crystal structure of human sonic hedgehog n-terminal domain 1.85Å AUTH R.B.PEPINSKY,P.RAYHORN,E.S.DAY,A.DERGAY,AUTH 2 K.P.WILLIAMS,A.GALDES,F.R.TAYLOR,AUTH 3 P.A.BORIACK-SJODIN,E.A.GARBERTITL MAPPING SONIC HEDGEHOG-RECEPTOR INTERACTIONS BYTITL 2 STERIC INTERFERENCE.REF J.BIOL.CHEM. V. 275 10995 2000REFN ISSN 0021-9258PMID 10753901DOI 10.1074/JBC.275.15.10995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2k60 STIM1 nmr structure of calcium-loaded stim1 ef-sam -1.0Å AUTH P.B.STATHOPULOS,L.ZHENG,G.Y.LI,M.J.PLEVIN,M.IKURATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO STIM1-MEDIATEDTITL 2 INITIATION OF STORE-OPERATED CALCIUM ENTRY.REF CELL(CAMBRIDGE,MASS.) V. 135 110 2008REFN ISSN 0092-8674PMID 18854159DOI 10.1016/J.CELL.2008.08.006 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants