Assessment of Structural Intolerance and Durability
General Structure Information 4irq B4GALT7 crystal structure of catalytic domain of human beta1, 4galactosyltransferase 7 in closed conformation in complex with manganese and udp 2.3Å AUTH Y.TSUTSUI,B.RAMAKRISHNAN,P.K.QASBATITL CRYSTAL STRUCTURES OF BETA-1,4-GALACTOSYLTRANSFERASE 7TITL 2 ENZYME REVEAL CONFORMATIONAL CHANGES AND SUBSTRATE BINDING.REF J.BIOL.CHEM. V. 288 31963 2013REFN ISSN 0021-9258PMID 24052259DOI 10.1074/JBC.M113.509984 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4fnw ALK crystal structure of the apo f1174l anaplastic lymphoma kinase catalytic domain 1.75Å AUTH L.F.EPSTEIN,H.CHEN,R.EMKEY,D.A.WHITTINGTONTITL THE R1275Q NEUROBLASTOMA MUTANT AND CERTAIN ATP-COMPETITIVETITL 2 INHIBITORS STABILIZE ALTERNATIVE ACTIVATION LOOPTITL 3 CONFORMATIONS OF ANAPLASTIC LYMPHOMA KINASE.REF J.BIOL.CHEM. V. 287 37447 2012REFN ISSN 0021-9258PMID 22932897DOI 10.1074/JBC.M112.391425 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3in5 POLK structure of human dna polymerase kappa inserting datp opposite an 8-oxog dna lesion 3.2Å AUTH R.VASQUEZ-DEL CARPIO,T.D.SILVERSTEIN,S.LONE,AUTH 2 M.K.SWAN,J.R.CHOUDHURY,R.E.JOHNSON,S.PRAKASH,AUTH 3 L.PRAKASH,A.K.AGGARWALTITL STRUCTURE OF HUMAN DNA POLYMERASE KAPPA INSERTINGTITL 2 DATP OPPOSITE AN 8-OXOG DNA LESIONREF PLOS ONE V. 4 E5766 2009REFN ESSN 1932-6203PMID 19492058DOI 10.1371/JOURNAL.PONE.0005766 Variant Set Distributions Pathogenic Proximity […]
General Structure Information 1×51 MUTYH solution structure of the nudix domain from human a/g- specific adenine dna glycosylase alpha-3 splice isoform -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE NUDIX DOMAIN FROM HUMANTITL 2 A/G-SPECIFIC ADENINE DNA GLYCOSYLASE ALPHA-3TITL 3 SPLICE ISOFORMREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2k40 HESX1 nmr structure of hesx-1 homeodomain double mutant r31l/e42l -1.0Å AUTH J.ASENSIO,M.TORRADO,C.GONZALEZ,A.BASTIDA,F.CORZANATITL THE ROLE OF CONSERVED SALT-BRIDGES ON HOMEODOMAINTITL 2 STABILITYREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1m6d CTSF crystal structure of human cathepsin f 1.7Å AUTH J.R.SOMOZA,J.T.PALMER,J.D.HOTITL THE CRYSTAL STRUCTURE OF HUMAN CATHEPSIN F AND ITSTITL 2 IMPLICATIONS FOR THE DEVELOPMENT OF NOVEL IMMUNOMODULATORSREF J.MOL.BIOL. V. 322 559 2002REFN ISSN 0022-2836PMID 12225749DOI 10.1016/S0022-2836(02)00780-5 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lgg CECR1 crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ada2) complexed with transition state analogue, coformycin 2.5Å AUTH A.V.ZAVIALOV,X.YU,D.SPILLMANN,G.LAUVAU,A.V.ZAVIALOVTITL STRUCTURAL BASIS FOR THE GROWTH FACTOR ACTIVITY OF HUMANTITL 2 ADENOSINE DEAMINASE ADA2.REF J.BIOL.CHEM. V. 285 12367 2010REFN ISSN 0021-9258PMID 20147294DOI 10.1074/JBC.M109.083527 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3vfd SPAST human spastin aaa domain 3.3Å AUTH J.L.TAYLOR,S.R.WHITE,B.LAURING,F.J.KULLTITL CRYSTAL STRUCTURE OF THE HUMAN SPASTIN AAA DOMAIN.REF J.STRUCT.BIOL. V. 179 133 2012REFN ISSN 1047-8477PMID 22446388DOI 10.1016/J.JSB.2012.03.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3nhb ABCB6 nucleotide binding domain of human abcb6 (adp bound structure) 2.15Å AUTH M.HAFFKE,A.MENZEL,Y.CARIUS,D.JAHN,D.W.HEINZTITL STRUCTURES OF THE NUCLEOTIDE-BINDING DOMAIN OF THE HUMANTITL 2 ABCB6 TRANSPORTER AND ITS COMPLEXES WITH NUCLEOTIDES.REF ACTA CRYSTALLOGR.,SECT.D V. 66 979 2010REFN ISSN 0907-4449PMID 20823549DOI 10.1107/S0907444910028593 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2xsw INPP5E crystal structure of human inpp5e 1.9Å AUTH L.TRESAUGUES,P.SCHUTZ,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WELIN,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN INPP5EREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants