Assessment of Structural Intolerance and Durability
General Structure Information 1k93 CALM2 crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 2.95Å AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1k93 CALM1 crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin 2.95Å AUTH C.L.DRUM,S.-Z.YAN,J.BARD,Y.-Q.SHEN,D.LU,AUTH 2 S.SOELAIMAN,Z.GRABAREK,A.BOHM,W.-J.TANGTITL STRUCTURAL BASIS FOR THE ACTIVATION OF ANTHRAXTITL 2 ADENYLYL CYCLASE EXOTOXIN BY CALMODULIN.REF NATURE V. 415 396 2002REFN ISSN 0028-0836PMID 11807546DOI 10.1038/415396A Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4my2 NDP crystal structure of norrin in fusion with maltose binding protein 2.4Å AUTH J.KE,K.G.HARIKUMAR,C.ERICE,C.CHEN,X.GU,L.WANG,N.PARKER,AUTH 2 Z.CHENG,W.XU,B.O.WILLIAMS,K.MELCHER,L.J.MILLER,H.E.XUTITL STRUCTURE AND FUNCTION OF NORRIN IN ASSEMBLY AND ACTIVATIONTITL 2 OF A FRIZZLED 4-LRP5/6 COMPLEX.REF GENES DEV. V. 27 2305 2013REFN ISSN 0890-9369PMID 24186977DOI 10.1101/GAD.228544.113 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d9s AQP5 human aquaporin 5 (aqp5) – high resolution x-ray structure 2.0Å AUTH R.HORSEFIELD,K.NORDEN,M.FELLERT,A.BACKMARK,AUTH 2 S.TORNROTH-HORSEFIELD,AUTH 3 A.C.TERWISSCHA VAN SCHELTINGA,J.KVASSMAN,AUTH 4 P.KJELLBOM,U.JOHANSON,R.NEUTZETITL HIGH-RESOLUTION X-RAY STRUCTURE OF HUMAN AQUAPORINTITL 2 5REF PROC.NATL.ACAD.SCI.USA V. 105 13327 2008REFN ISSN 0027-8424PMID 18768791DOI 10.1073/PNAS.0801466105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1tzn ANTXR2 crystal structure of the anthrax toxin protective antigen heptameric prepore bound to the vwa domain of cmg2, an anthrax toxin receptor 4.3Å AUTH D.B.LACY,D.J.WIGELSWORTH,R.A.MELNYK,S.C.HARRISON,R.J.COLLIERTITL STRUCTURE OF HEPTAMERIC PROTECTIVE ANTIGEN BOUND TO ANTITL 2 ANTHRAX TOXIN RECEPTOR: A ROLE FOR RECEPTOR IN PH-DEPENDENTTITL 3 PORE FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 101 13147 2004REFN […]
General Structure Information 1tzn ANTXR2 crystal structure of the anthrax toxin protective antigen heptameric prepore bound to the vwa domain of cmg2, an anthrax toxin receptor 4.3Å AUTH D.B.LACY,D.J.WIGELSWORTH,R.A.MELNYK,S.C.HARRISON,R.J.COLLIERTITL STRUCTURE OF HEPTAMERIC PROTECTIVE ANTIGEN BOUND TO ANTITL 2 ANTHRAX TOXIN RECEPTOR: A ROLE FOR RECEPTOR IN PH-DEPENDENTTITL 3 PORE FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 101 13147 2004REFN […]
General Structure Information 1fvr TEK tie2 kinase domain 2.2Å AUTH L.M.SHEWCHUK,A.M.HASSELL,B.ELLIS,W.D.HOLMES,AUTH 2 R.DAVIS,E.L.HORNE,S.H.KADWELL,D.D.MCKEE,J.T.MOORETITL STRUCTURE OF THE TIE2 RTK DOMAIN: SELF-INHIBITIONTITL 2 BY THE NUCLEOTIDE BINDING LOOP, ACTIVATION LOOP,TITL 3 AND C-TERMINAL TAIL.REF STRUCTURE FOLD.DES. V. 8 1105 2000REFN ISSN 0969-2126PMID 11080633DOI 10.1016/S0969-2126(00)00516-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4bgg ACVR1 crystal structure of the acvr1 kinase in complex with ldn-213844 2.56Å AUTH A.H.MOHEDAS,Y.WANG,C.E.SANVITALE,P.CANNING,S.CHOI,X.XING,AUTH 2 A.N.BULLOCK,G.D.CUNY,P.B.YUTITL STRUCTURE-ACTIVITY RELATIONSHIP OF 3,5-DIARYL-2-TITL 2 AMINOPYRIDINE ALK2 INHIBITORS REVEALS UNALTERED BINDINGTITL 3 AFFINITY FOR FIBRODYSPLASIA OSSIFICANS PROGRESSIVA CAUSINGTITL 4 MUTANTS.REF J.MED.CHEM. V. 57 7900 2014REFN ISSN 0022-2623PMID 25101911DOI 10.1021/JM501177W Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1q9c SOS1 crystal structure of the histone domain of son of sevenless 3.21Å AUTH H.SONDERMANN,S.M.SOISSON,D.BAR-SAGI,J.KURIYANTITL TANDEM HISTONE FOLDS IN THE STRUCTURE OF THETITL 2 N-TERMINAL SEGMENT OF THE RAS ACTIVATOR SON OFTITL 3 SEVENLESSREF STRUCTURE V. 11 1583 2003REFN ISSN 0969-2126PMID 14656442DOI 10.1016/J.STR.2003.10.015 Variant Set Distributions Mapped Variants
General Structure Information 2qyn PDE4D crystal structure of pde4d2 in complex with inhibitor npv 1.57Å AUTH H.WANG,M.S.PENG,Y.CHEN,J.GENG,H.ROBINSON,AUTH 2 M.D.HOUSLAY,J.CAI,H.KETITL STRUCTURES OF THE FOUR SUBFAMILIES OFTITL 2 PHOSPHODIESTERASE-4 PROVIDE INSIGHT INTO THETITL 3 SELECTIVITY OF THEIR INHIBITORS.REF BIOCHEM.J. V. 408 193 2007REFN ISSN 0264-6021PMID 17727341DOI 10.1042/BJ20070970 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]