General Structure Information
| PDB ID | 1tzn |
| HGNC Gene Label(s) | ANTXR2 |
| Structure Name | crystal structure of the anthrax toxin protective antigen heptameric prepore bound to the vwa domain of cmg2, an anthrax toxin receptor |
| Resolution | 4.3Å |
| Reference | AUTH D.B.LACY,D.J.WIGELSWORTH,R.A.MELNYK,S.C.HARRISON,R.J.COLLIERTITL STRUCTURE OF HEPTAMERIC PROTECTIVE ANTIGEN BOUND TO ANTITL 2 ANTHRAX TOXIN RECEPTOR: A ROLE FOR RECEPTOR IN PH-DEPENDENTTITL 3 PORE FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 101 13147 2004REFN ISSN 0027-8424PMID 15326297DOI 10.1073/PNAS.0405405101 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 181 |
| Number Of SNVs | 34 |
| Number Of Permutations | 8343 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.043 |
| p-value | 0.234 |
ClinVar
| Number Of Residues | 181 |
| Number Of SNVs | 3 |
| Number Of Permutations | 108 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.333 |
| p-value | 0.563 |
Ripley’s K Analysis Plots
ClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.251 |
| p-value | 0.423 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
