Assessment of Structural Intolerance and Durability
General Structure Information 2k1v INSL5 r3/i5 relaxin chimera -1.0Å AUTH L.M.HAUGAARD-JONSSON,M.A.HOSSAIN,N.L.DALY,AUTH 2 R.A.BATHGATE,J.D.WADE,D.J.CRAIK,K.J.ROSENGRENTITL STRUCTURE OF THE R3/I5 CHIMERIC RELAXIN PEPTIDE, ATITL 2 SELECTIVE GPCR135 AND GPCR142 AGONIST.REF J.BIOL.CHEM. V. 283 23811 2008REFN ISSN 0021-9258PMID 18577524DOI 10.1074/JBC.M800489200 Variant Set Distributions Mapped Variants
General Structure Information 3g5c ADAM22 structural and biochemical studies on the ectodomain of human adam22 2.36Å AUTH H.LIU,A.SHIM,X.CHEN,X.HETITL STRUCTURAL AND BIOCHEMICAL STUDIES ON THE ECTODOMAIN OFTITL 2 HUMAN ADAM22REF J.BIOL.CHEM. 2009REFN ESSN 1083-351X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3jyh DPP7 human dipeptidyl peptidase dpp7 2.19Å AUTH E.DOBROVETSKY,A.DONG,A.SEITOVA,L.CROMBETT,S.PAGANON,AUTH 2 D.COSSAR,A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,AUTH 3 A.HASSEL,L.SHEWCHUK,A.BOCHKAREVTITL HUMAN DIPEPTIDYL PEPTIDASE DPP7REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3jtc PROCR importance of mg2+ in the ca2+-dependent folding of the gamma- carboxyglutamic acid domains of vitamin k-dependent clotting and anticlotting proteins 1.6Å AUTH K.VADIVEL,S.AGAH,A.S.MESSER,D.CASCIO,M.S.BAJAJ,AUTH 2 S.KRISHNASWAMY,C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL STRUCTURAL AND FUNCTIONAL STUDIES OF GAMMA-CARBOXYGLUTAMICTITL 2 ACID DOMAINS OF FACTOR VIIA AND ACTIVATED PROTEIN C: ROLE OFTITL 3 MAGNESIUM AT PHYSIOLOGICAL CALCIUM.REF J.MOL.BIOL. V. […]
General Structure Information 2rjq ADAMTS5 crystal structure of adamts5 with inhibitor bound 2.6Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,T.MCDONAGH,AUTH 2 S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,E.L.REIFENBERG,AUTH 3 L.A.COLLINS-RACIE,C.CORCORAN,B.FREEMAN,R.ZOLLNER,T.MARVELL,AUTH 4 M.VERA,P.E.SUM,E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECAN DEGRADINGTITL 2 ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3h5c SERPINA10 x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2ytw HTRA1 solution structure of the pdz-domain of human protease htra 1 precursor -1.0Å AUTH A.K.GORONCY,K.SAITO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ-DOMAIN OF HUMANTITL 2 PROTEASE HTRA 1 PRECURSORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ff7 KLRG1 structure of nk cell receptor klrg1 bound to e-cadherin 1.8Å AUTH Y.LI,M.HOFMANN,Q.WANG,L.TENG,L.K.CHLEWICKI,AUTH 2 H.PIRCHER,R.A.MARIUZZATITL STRUCTURE OF NATURAL KILLER CELL RECEPTOR KLRG1TITL 2 BOUND TO E-CADHERIN REVEALS BASIS FORTITL 3 MHC-INDEPENDENT MISSING SELF RECOGNITION.REF IMMUNITY V. 31 35 2009REFN ISSN 1074-7613PMID 19604491DOI 10.1016/J.IMMUNI.2009.04.019 Variant Set Distributions Mapped Variants
General Structure Information 4fjv OTUB2 crystal structure of human otubain2 and ubiquitin complex 2.05Å AUTH M.ALTUN,T.S.WALTER,H.B.KRAMER,P.HERR,A.IPHOFER,J.BOSTROM,AUTH 2 Y.DAVID,A.KOMSANY,N.TERNETTE,A.NAVON,D.I.STUART,J.REN,AUTH 3 B.M.KESSLERTITL THE HUMAN OTUBAIN2-UBIQUITIN STRUCTURE PROVIDES INSIGHTSTITL 2 INTO THE CLEAVAGE SPECIFICITY OF POLY-UBIQUITIN-LINKAGES.REF PLOS ONE V. 10 15344 2015REFN ESSN 1932-6203PMID 25590432DOI 10.1371/JOURNAL.PONE.0115344 Variant Set Distributions Mapped Variants
General Structure Information 3gcw PCSK9 pcsk9:egfa(h306y) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants