General Structure Information 2zmf PDE10A crystal structure of the c-terminal gaf domain of human phosphodiesterase 10a 2.1Å AUTH N.HANDA,E.MIZOHATA,S.KISHISHITA,M.TOYAMA,S.MORITA,AUTH 2 T.UCHIKUBO-KAMO,R.AKASAKA,K.OMORI,J.KOTERA,T.TERADA,AUTH 3 M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE GAF-B DOMAIN FROM HUMANTITL 2 PHOSPHODIESTERASE 10A COMPLEXED WITH ITS LIGAND, CAMPREF J.BIOL.CHEM. V. 283 19657 2008REFN ISSN 0021-9258PMID 18477562DOI 10.1074/JBC.M800595200 Variant Set Distributions Mapped Variants
General Structure Information 4ku8 PRKG1 structures of pkgi reveal a cgmp-selective activation mechanism 1.99Å AUTH G.Y.HUANG,J.J.KIM,A.S.REGER,R.LORENZ,E.W.MOON,C.ZHAO,AUTH 2 D.E.CASTEEL,D.BERTINETTI,B.VANSCHOUWEN,R.SELVARATNAM,AUTH 3 J.W.PFLUGRATH,B.SANKARAN,G.MELACINI,F.W.HERBERG,C.KIMTITL STRUCTURAL BASIS FOR CYCLIC-NUCLEOTIDE SELECTIVITY ANDTITL 2 CGMP-SELECTIVE ACTIVATION OF PKG I.REF STRUCTURE V. 22 116 2014REFN ISSN 0969-2126PMID 24239458DOI 10.1016/J.STR.2013.09.021 Variant Set Distributions Mapped Variants
General Structure Information 2wz1 GUCY1B3 structure of the catalytic domain of human soluble guanylate cyclase 1 beta 3. 1.63Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ISSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Mapped Variants
General Structure Information 3uvj GUCY1A3 crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. 2.08Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ESSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2wz1 GUCY1B3 structure of the catalytic domain of human soluble guanylate cyclase 1 beta 3. 1.63Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ISSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Mapped Variants
General Structure Information 3uvj GUCY1A3 crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. 2.08Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ESSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3jwq PDE6C crystal structure of chimeric pde5/pde6 catalytic domain complexed with sildenafil 2.87Å AUTH B.BARREN,L.GAKHAR,H.MURADOV,K.K.BOYD,S.RAMASWAMY,AUTH 2 N.O.ARTEMYEVTITL STRUCTURAL BASIS OF PHOSPHODIESTERASE 6 INHIBITION BY THETITL 2 C-TERMINAL REGION OF THE GAMMA-SUBUNITREF EMBO J. V. 28 3613 2009REFN ISSN 0261-4189PMID 19798052DOI 10.1038/EMBOJ.2009.284 Variant Set Distributions Mapped Variants
General Structure Information 3bjc PDE5A crystal structure of the pde5a catalytic domain in complex with a novel inhibitor 2.0Å AUTH G.CHEN,H.WANG,H.ROBINSON,J.CAI,Y.WAN,H.KETITL AN INSIGHT INTO THE PHARMACOPHORES OFTITL 2 PHOSPHODIESTERASE-5 INHIBITORS FROM SYNTHETIC ANDTITL 3 CRYSTAL STRUCTURAL STUDIESREF BIOCHEM.PHARM. V. 75 1717 2008REFN ISSN 0006-2952PMID 18346713DOI 10.1016/J.BCP.2008.01.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3ibj PDE2A x-ray structure of pde2a 3.02Å AUTH J.PANDIT,M.D.FORMAN,K.F.FENNELL,K.S.DILLMAN,F.S.MENNITITITL MECHANISM FOR THE ALLOSTERIC REGULATION OF PHOSPHODIESTERASETITL 2 2A DEDUCED FROM THE X-RAY STRUCTURE OF A NEAR FULL-LENGTHTITL 3 CONSTRUCT.REF PROC.NATL.ACAD.SCI.USA V. 106 18225 2009REFN ISSN 0027-8424PMID 19828435DOI 10.1073/PNAS.0907635106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants