General Structure Information 3com STK4 crystal structure of mst1 kinase 2.2Å AUTH S.ATWELL,S.K.BURLEY,M.DICKEY,B.LEON,J.M.SAUDERTITL CRYSTAL STRUCTURE OF MST1 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
Assessment of Structural Intolerance and Durability
General Structure Information 3com STK4 crystal structure of mst1 kinase 2.2Å AUTH S.ATWELL,S.K.BURLEY,M.DICKEY,B.LEON,J.M.SAUDERTITL CRYSTAL STRUCTURE OF MST1 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2fh7 PTPRS crystal structure of the phosphatase domains of human ptp sigma 2.0Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2rii PRDX1 crystal structure of human peroxiredoxin i in complex with sulfiredoxin 2.6Å AUTH T.J.JONSSON,L.C.JOHNSON,W.T.LOWTHERTITL STRUCTURE OF THE SULPHIREDOXIN-PEROXIREDOXIN COMPLEX REVEALSTITL 2 AN ESSENTIAL REPAIR EMBRACE.REF NATURE V. 451 98 2008REFN ISSN 0028-0836PMID 18172504DOI 10.1038/NATURE06415 Variant Set Distributions Mapped Variants
General Structure Information 3u0d LCN2 the structure of human siderocalin bound to the bacterial siderophore 2,3-dhba 2.51Å AUTH C.CORRENTI,V.RICHARDSON,A.K.SIA,A.D.BANDARANAYAKE,M.RUIZ,AUTH 2 Y.SURYO RAHMANTO,Z.KOVACEVIC,M.C.CLIFTON,M.A.HOLMES,AUTH 3 B.K.KAISER,J.BARASCH,K.N.RAYMOND,D.R.RICHARDSON,R.K.STRONGTITL SIDEROCALIN/LCN2/NGAL/24P3 DOES NOT DRIVE APOPTOSIS THROUGHTITL 2 GENTISIC ACID MEDIATED IRON WITHDRAWAL IN HEMATOPOIETIC CELLTITL 3 LINES.REF PLOS ONE V. 7 43696 2012REFN ESSN 1932-6203PMID 22928018DOI 10.1371/JOURNAL.PONE.0043696 Variant Set Distributions Mapped […]
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]
General Structure Information 3gd8 AQP4 crystal structure of human aquaporin 4 at 1.8 and its mechanism of conductance 1.8Å AUTH J.D.HO,R.YEH,A.SANDSTROM,I.CHORNY,W.E.HARRIES,R.A.ROBBINS,AUTH 2 L.J.MIERCKE,R.M.STROUDTITL CRYSTAL STRUCTURE OF HUMAN AQUAPORIN 4 AT 1.8 A AND ITSTITL 2 MECHANISM OF CONDUCTANCE.REF PROC.NATL.ACAD.SCI.USA V. 106 7437 2009REFN ISSN 0027-8424PMID 19383790DOI 10.1073/PNAS.0902725106 Variant Set Distributions Mapped Variants
General Structure Information 2bba EPHB4 crystal structure and thermodynamic characterization of the ephb4 receptor in complex with an ephrin-b2 antagonist peptide reveals the determinants for receptor specificity. 1.65Å AUTH J.E.CHRENCIK,A.BROOUN,M.I.RECHT,M.L.KRAUS,M.KOOLPE,AUTH 2 A.R.KOLATKAR,R.H.BRUCE,G.MARTINY-BARON,H.WIDMER,AUTH 3 E.B.PASQUALE,P.KUHNTITL STRUCTURE AND THERMODYNAMIC CHARACTERIZATION OF THETITL 2 EPHB4/EPHRIN-B2 ANTAGONIST PEPTIDE COMPLEX REVEALS THETITL 3 DETERMINANTS FOR RECEPTOR SPECIFICITY.REF STRUCTURE V. 14 […]
General Structure Information 2hle EFNB2 structural and biophysical characterization of the ephb4-ephrinb2 protein protein interaction and receptor specificity. 2.05Å AUTH J.E.CHRENCIK,A.BROOUN,M.L.KRAUS,M.I.RECHT,A.R.KOLATKAR,AUTH 2 G.W.HAN,J.M.SEIFERT,H.WIDMER,M.AUER,P.KUHNTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THETITL 2 EPHB4-EPHRINB2 PROTEIN-PROTEIN INTERACTION AND RECEPTORTITL 3 SPECIFICITY.REF J.BIOL.CHEM. V. 281 28185 2006REFN ISSN 0021-9258PMID 16867992DOI 10.1074/JBC.M605766200 Variant Set Distributions Mapped Variants
General Structure Information 2qnk HAAO crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase 1.6Å AUTH E.BITTO,C.A.BINGMAN,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF HUMAN 3-HYDROXYANTHRANILATETITL 2 3,4-DIOXYGENASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fsv HSPA2 crystal structure of a heat shock 70kda protein 2 (hspa2) from homo sapiens at 1.80 a resolution 1.8Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A HEAT SHOCK 70KDA PROTEIN 2 (HSPA2)TITL 2 FROM HOMO SAPIENS AT 1.80 A RESOLUTIONREF TO […]