3COM.A | STK4 – ASTRID

3COM.A | STK4

General Structure Information

PDB ID	3com
HGNC Gene Label(s)	STK4
Structure Name	crystal structure of mst1 kinase
Resolution	2.2Å
Reference	AUTH S.ATWELL,S.K.BURLEY,M.DICKEY,B.LEON,J.M.SAUDERTITL CRYSTAL STRUCTURE OF MST1 KINASE.REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	264
Number Of SNVs	55
Number Of Permutations	7982
Optimal Distance Threshold	7.0
K Statistic	0.041
p-value	0.38

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
20:43600790		L>P	A:36	(50.24, 60.31, 43.58)
20:43607109		I>V	A:48	(53.96, 69.97, 52.34)
20:43607113		H>L	A:49	(49.94, 73.32, 55.26)
20:43607134	rs374689115	V>A	A:56	(48.10, 67.27, 51.57)
20:43607145	rs545381981	Q>E	A:60	(44.23, 69.10, 39.44)
20:43610472	COSM3911425 COSM3911426	P>L	A:83	(37.35, 59.18, 61.05)
20:43610484		K>R	A:87	(38.67, 65.00, 56.13)
20:43610510		T>A	A:96	(42.95, 78.02, 34.22)
20:43610511	rs141098686	T>I	A:96	(42.95, 78.02, 34.22)
20:43610515		D>E	A:97	(43.93, 74.90, 36.96)
20:43610525	rs375543946	V>I	A:101	(42.91, 70.49, 49.39)
20:43610526		V>A	A:101	(42.91, 70.49, 49.39)
20:43610561		I>V	A:113	(47.36, 47.41, 47.94)
20:43610574	rs202040819	R>Q	A:117	(50.92, 42.35, 47.96)
20:43610579		K>E	A:119	(49.60, 39.03, 46.96)
20:43610583	rs368513990 COSM1027148 COSM1027149	T>M	A:120	(44.46, 38.41, 47.23)
20:43615782		D>N	A:124	(42.34, 38.43, 59.34)
20:43615783		D>V	A:124	(42.34, 38.43, 59.34)
20:43615794		T>P	A:128	(40.37, 44.96, 59.65)
20:43615797		I>V	A:129	(39.69, 46.80, 55.56)
20:43615799	rs371332575	I>M	A:129	(39.69, 46.80, 55.56)
20:43615806		S>A	A:132	(36.53, 50.72, 59.02)
20:43615809		T>A	A:133	(34.14, 50.44, 55.52)
20:43615850		I>M	A:146	(23.42, 56.73, 49.09)
20:43615855	rs374685235	R>Q	A:148	(24.75, 56.21, 44.47)
20:43615885		N>S	A:158	(46.29, 55.64, 56.51)
20:43615890		E>K	A:160	(48.37, 53.54, 59.92)
20:43615896	rs55850759	H>N	A:162	(43.37, 53.84, 60.24)
20:43615924		A>V	A:171	(26.30, 60.55, 45.77)
20:43623797		E>Q	A:198	(12.91, 51.32, 38.53)
20:43623802		I>M	A:199	(12.44, 50.21, 42.21)
20:43623815		V>I	A:204	(20.67, 49.12, 51.97)
20:43623824	rs377733474	I>V	A:207	(25.19, 46.87, 52.39)
20:43623825	rs201578965	I>T	A:207	(25.19, 46.87, 52.39)
20:43623893		M>V	A:230	(25.92, 47.13, 29.64)
20:43625813		I>V	A:233	(23.22, 45.67, 34.53)
20:43625820	rs370157810	M>T	A:235	(22.72, 38.87, 34.70)
20:43625829		T>R	A:238	(17.47, 37.85, 37.24)
20:43625832		N>S	A:239	(20.95, 35.94, 38.59)
20:43625837	rs371236375	P>S	A:241	(22.55, 35.63, 45.25)
20:43625841		P>L	A:242	(26.43, 36.49, 44.29)
20:43625850		R>Q	A:245	(34.79, 33.09, 41.64)
20:43625862		L>P	A:249	(39.37, 29.01, 50.08)
20:43625874	rs149432644	N>S	A:253	(32.19, 33.69, 60.13)
20:43625880		T>I	A:255	(30.45, 32.51, 53.81)
20:43625882		D>N	A:256	(26.96, 34.46, 56.91)
20:43625886		F>C	A:257	(29.80, 39.70, 55.85)
20:43625888	rs372125666	V>M	A:258	(28.87, 37.65, 51.72)
20:43625889		V>A	A:258	(28.87, 37.65, 51.72)
20:43625891	rs544097245	K>E	A:259	(23.91, 34.84, 53.00)
20:43625901		L>P	A:262	(24.67, 39.67, 48.69)
20:43625910		S>T	A:265	(15.30, 42.17, 49.80)
20:43625912	rs143845252	P>T	A:266	(15.86, 45.69, 49.75)
20:43625920		Q>H	A:268	(14.65, 41.13, 54.02)
20:43625931		A>G	A:272	(25.84, 48.82, 59.02)
20:43625939	rs373362307	L>V	A:275	(26.74, 43.89, 59.23)
20:43629060	rs372387562	V>M	A:287	(45.22, 48.38, 62.16)
20:43629061		V>A	A:287	(45.22, 48.38, 62.16)
20:43629066		I>V	A:289	(46.68, 42.91, 60.95)
20:43629073		R>Q	A:291	(51.88, 47.04, 61.26)
20:43629076	rs569736817	D>G	A:292	(52.99, 42.84, 56.76)
20:43629091		A>V	A:297	(53.33, 48.04, 48.93)