Assessment of Structural Intolerance and Durability
General Structure Information 3pja TSN crystal structure of human c3po complex 3.0Å AUTH X.YE,N.HUANG,Y.LIU,Z.PAROO,C.HUERTA,P.LI,S.CHEN,Q.LIU,AUTH 2 H.ZHANGTITL STRUCTURE OF C3PO AND MECHANISM OF HUMAN RISC ACTIVATION.REF NAT.STRUCT.MOL.BIOL. V. 18 650 2011REFN ISSN 1545-9993PMID 21552258DOI 10.1038/NSMB.2032 Variant Set Distributions Mapped Variants
General Structure Information 3u3f PTK2B structural basis for the interaction of pyk2 pat domain with paxillin ld motifs 3.1Å AUTH M.S.VANAROTTI,D.J.MILLER,C.D.GUIBAO,A.NOURSE,J.J.ZHENGTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO THE INTERACTIONTITL 2 BETWEEN PYK2 AND PAXILLIN LD MOTIFS.REF J.MOL.BIOL. V. 426 3985 2014REFN ISSN 0022-2836PMID 25174335DOI 10.1016/J.JMB.2014.08.014 Variant Set Distributions Mapped Variants
General Structure Information 3hrn PKD2 crystal structure of a c-terminal coiled coil domain of transient receptor potential (trp) channel subfamily p member 2 (trpp2, polycystic kidney disease 2) 1.9Å AUTH Y.YU,M.H.ULBRICH,M.H.LI,Z.BURAEI,X.Z.CHEN,A.C.ONG,AUTH 2 L.TONG,E.Y.ISACOFF,J.YANGTITL STRUCTURAL AND MOLECULAR BASIS OF THE ASSEMBLY OFTITL 2 THE TRPP2/PKD1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 106 11558 2009REFN ISSN 0027-8424PMID 19556541DOI 10.1073/PNAS.0903684106 Variant […]
General Structure Information 1j7v IL10RA human il-10 / il-10r1 complex 2.9Å AUTH K.JOSEPHSON,N.J.LOGSDON,M.R.WALTERTITL CRYSTAL STRUCTURE OF THE IL-10/IL-10R1 COMPLEXTITL 2 REVEALS A SHARED RECEPTOR BINDING SITE.REF IMMUNITY V. 15 35 2001REFN ISSN 1074-7613PMID 11485736DOI 10.1016/S1074-7613(01)00169-8 Variant Set Distributions Mapped Variants
General Structure Information 1k05 PTK2 crystal structure of the focal adhesion targeting domain of focal adhesion kinase 2.9Å AUTH S.T.AROLD,M.K.HOELLERER,M.E.NOBLETITL THE STRUCTURAL BASIS OF LOCALIZATION AND SIGNALINGTITL 2 BY THE FOCAL ADHESION TARGETING DOMAIN.REF STRUCTURE V. 10 319 2002REFN ISSN 0969-2126PMID 12005431DOI 10.1016/S0969-2126(02)00717-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3qt2 IL5RA structure of a cytokine ligand-receptor complex 2.55Å AUTH E.PATINO,A.KOTZSCH,S.SAREMBA,J.NICKEL,W.SCHMITZ,W.SEBALD,AUTH 2 T.D.MUELLERTITL STRUCTURE ANALYSIS OF THE IL-5 LIGAND-RECEPTOR COMPLEXTITL 2 REVEALS A WRENCH-LIKE ARCHITECTURE FOR IL-5RALPHA.REF STRUCTURE V. 19 1864 2011REFN ISSN 0969-2126PMID 22153509DOI 10.1016/J.STR.2011.08.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pp4 RUNX1T1 solution structure of eto-tafh refined in explicit solvent -1.0Å AUTH Y.WEI,S.LIU,J.LAUSEN,C.WOODRELL,S.CHO,N.BIRIS,AUTH 2 N.KOBAYASHI,Y.WEI,S.YOKOYAMA,M.H.WERNERTITL A TAF4-HOMOLOGY DOMAIN FROM THE COREPRESSOR ETO ISTITL 2 A DOCKING PLATFORM FOR POSITIVE AND NEGATIVETITL 3 REGULATORS OF TRANSCRIPTIONREF NAT.STRUCT.MOL.BIOL. V. 14 653 2007REFN ISSN 1545-9993PMID 17572682DOI 10.1038/NSMB1258 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3qt2 IL5RA structure of a cytokine ligand-receptor complex 2.55Å AUTH E.PATINO,A.KOTZSCH,S.SAREMBA,J.NICKEL,W.SCHMITZ,W.SEBALD,AUTH 2 T.D.MUELLERTITL STRUCTURE ANALYSIS OF THE IL-5 LIGAND-RECEPTOR COMPLEXTITL 2 REVEALS A WRENCH-LIKE ARCHITECTURE FOR IL-5RALPHA.REF STRUCTURE V. 19 1864 2011REFN ISSN 0969-2126PMID 22153509DOI 10.1016/J.STR.2011.08.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pp4 RUNX1T1 solution structure of eto-tafh refined in explicit solvent -1.0Å AUTH Y.WEI,S.LIU,J.LAUSEN,C.WOODRELL,S.CHO,N.BIRIS,AUTH 2 N.KOBAYASHI,Y.WEI,S.YOKOYAMA,M.H.WERNERTITL A TAF4-HOMOLOGY DOMAIN FROM THE COREPRESSOR ETO ISTITL 2 A DOCKING PLATFORM FOR POSITIVE AND NEGATIVETITL 3 REGULATORS OF TRANSCRIPTIONREF NAT.STRUCT.MOL.BIOL. V. 14 653 2007REFN ISSN 1545-9993PMID 17572682DOI 10.1038/NSMB1258 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1dgn CARD18 solution structure of iceberg, an inhibitor of interleukin- 1beta generation -1.0Å AUTH E.W.HUMKE,S.K.SHRIVER,M.A.STAROVASNIK,AUTH 2 W.J.FAIRBROTHER,V.M.DIXITTITL ICEBERG: A NOVEL INHIBITOR OF INTERLEUKIN-1BETATITL 2 GENERATION.REF CELL(CAMBRIDGE,MASS.) V. 103 99 2000REFN ISSN 0092-8674PMID 11051551DOI 10.1016/S0092-8674(00)00108-2 Variant Set Distributions Mapped Variants