Assessment of Structural Intolerance and Durability
General Structure Information 1×86 ARHGEF12 crystal structure of the dh/ph domains of leukemia-associated rhogef in complex with rhoa 3.22Å AUTH R.KRISTELLY,G.GAO,J.J.TESMERTITL STRUCTURAL DETERMINANTS OF RHOA BINDING AND NUCLEOTIDETITL 2 EXCHANGE IN LEUKEMIA-ASSOCIATED RHO GUANINE-NUCLEOTIDETITL 3 EXCHANGE FACTOR.REF J.BIOL.CHEM. V. 279 47352 2004REFN ISSN 0021-9258PMID 15331592DOI 10.1074/JBC.M406056200 Variant Set Distributions Mapped Variants
General Structure Information 3vro CBLC crystal structure of the tyrosine kinase binding domain of cbl-c in complex with phospho-src peptide 1.8Å AUTH K.TAKESHITA,T.TEZUKA,Y.ISOZAKI,E.YAMASHITA,M.SUZUKI,M.KIM,AUTH 2 Y.YAMANASHI,T.YAMAMOTO,A.NAKAGAWATITL STRUCTURAL FLEXIBILITY REGULATES PHOSPHOPEPTIDE-BINDINGTITL 2 ACTIVITY OF THE TYROSINE KINASE BINDING DOMAIN OF CBL-C.REF J.BIOCHEM. V. 152 487 2012REFN ISSN 0021-924XPMID 22888118DOI 10.1093/JB/MVS085 Variant Set Distributions Mapped Variants
General Structure Information 2lc3 HECTD1 solution nmr structure of a helical bundle domain from human e3 ligase hectd1. northeast structural genomics consortium (nesg) target ht6305a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.ARROWSMITH,AUTH 2 S.DHE-PAGANONTITL NMR SOLUTION STRUCTURE OF A HELICAL BUNDLE FROM THE E3TITL 2 LIGASE HECTD1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wr6 GGA3 crystal structure of gga3 gat domain in complex with ubiquitin 2.6Å AUTH M.KAWASAKI,T.SHIBA,Y.SHIBA,Y.YAMAGUCHI,N.MATSUGAKI,AUTH 2 N.IGARASHI,M.SUZUKI,R.KATO,K.KATO,K.NAKAYAMA,AUTH 3 S.WAKATSUKITITL MOLECULAR MECHANISM OF UBIQUITIN RECOGNITION BYTITL 2 GGA3 GAT DOMAIN.REF GENES CELLS V. 10 639 2005REFN ISSN 1356-9597PMID 15966896DOI 10.1111/J.1365-2443.2005.00865.X Variant Set Distributions Mapped Variants
General Structure Information 1n1f IL19 crystal structure of human interleukin-19 1.95Å AUTH C.CHANG,E.MAGRACHEVA,S.KOZLOV,S.FONG,G.TOBIN,S.KOTENKO,AUTH 2 A.WLODAWER,A.ZDANOVTITL CRYSTAL STRUCTURE OF INTERLEUKIN-19 DEFINES A NEW SUBFAMILYTITL 2 OF HELICAL CYTOKINESREF J.BIOL.CHEM. V. 278 3308 2003REFN ISSN 0021-9258PMID 12403790DOI 10.1074/JBC.M208602200 Variant Set Distributions Mapped Variants
General Structure Information 1wiz SATB2 solution structure of the first cut domain of kiaa1034 protein -1.0Å AUTH K.INOUE,S.NAMEKI,F.HAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST CUT DOMAIN OFTITL 2 KIAA1034 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kzs DAXX daxx helical bundle (dhb) domain -1.0Å AUTH E.ESCOBAR-CABRERA,D.K.LAU,S.GIOVINAZZI,A.M.ISHOV,AUTH 2 L.P.MCINTOSHTITL STRUCTURAL CHARACTERIZATION OF THE DAXX N-TERMINAL HELICALTITL 2 BUNDLE DOMAIN AND ITS COMPLEX WITH RASSF1C.REF STRUCTURE V. 18 1642 2010REFN ISSN 0969-2126PMID 21134643DOI 10.1016/J.STR.2010.09.016 Variant Set Distributions Mapped Variants
General Structure Information 3l4g FARSB crystal structure of homo sapiens cytoplasmic phenylalanyl-trna synthetase 3.3Å AUTH I.FINAROV,N.MOOR,N.KESSLER,L.KLIPCAN,M.G.SAFROTITL STRUCTURE OF HUMAN CYTOSOLIC PHENYLALANYL-TRNA SYNTHETASE:TITL 2 EVIDENCE FOR KINGDOM-SPECIFIC DESIGN OF THE ACTIVE SITESTITL 3 AND TRNA BINDING PATTERNS.REF STRUCTURE V. 18 343 2010REFN ISSN 0969-2126PMID 20223217DOI 10.1016/J.STR.2010.01.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2i7k BRD7 solution structure of the bromodomain of human brd7 protein -1.0Å AUTH H.SUN,J.LIU,J.ZHANG,W.SHEN,H.HUANG,C.XU,H.DAI,J.WU,AUTH 2 Y.SHITITL SOLUTION STRUCTURE OF BRD7 BROMODOMAIN AND ITSTITL 2 INTERACTION WITH ACETYLATED PEPTIDES FROM HISTONETITL 3 H3 AND H4REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 358 435 2007REFN ISSN 0006-291XPMID 17498659DOI 10.1016/J.BBRC.2007.04.139 Variant Set Distributions Mapped Variants
General Structure Information 2pz1 ARHGEF4 crystal structure of auto-inhibited asef 2.25Å AUTH N.MITIN,L.BETTS,M.E.YOHE,C.J.DER,J.SONDEK,K.L.ROSSMANTITL RELEASE OF AUTOINHIBITION OF ASEF BY APC LEADS TO CDC42TITL 2 ACTIVATION AND TUMOR SUPPRESSION.REF NAT.STRUCT.MOL.BIOL. V. 14 814 2007REFN ISSN 1545-9993PMID 17704816DOI 10.1038/NSMB1290 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants