Assessment of Structural Intolerance and Durability
General Structure Information 3duh IL23A structure of interleukin-23 2.3Å AUTH P.J.LUPARDUS,K.C.GARCIATITL THE STRUCTURE OF INTERLEUKIN-23 REVEALS THE MOLECULAR BASISTITL 2 OF P40 SUBUNIT SHARING WITH INTERLEUKIN-12.REF J.MOL.BIOL. V. 382 931 2008REFN ISSN 0022-2836PMID 18680750DOI 10.1016/J.JMB.2008.07.051 Variant Set Distributions Mapped Variants
General Structure Information 2y9t TP63 structural basis of p63a sam domain mutants involved in aec syndrome -1.0Å AUTH A.SATHYAMURTHY,S.M.V.FREUND,C.M.JOHNSON,M.D.ALLEN,M.BYCROFTTITL STRUCTURAL BASIS OF P63ALPHA SAM DOMAIN MUTANTS INVOLVED INTITL 2 AEC SYNDROME.REF FEBS J. V. 278 2680 2011REFN ISSN 1742-464XPMID 21615690DOI 10.1111/J.1742-4658.2011.08194.X Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2z0v SH3GL3 crystal structure of bar domain of endophilin-iii 2.49Å AUTH K.MURAYAMA,M.KATO-MURAYAMA,T.TERADA,M.SHIROUZU,AUTH 2 S.YOKOYAMATITL CRYSTAL STRUCTURE OF BAR DOMAIN OF ENDOPHILIN-IIIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3pja TSNAX crystal structure of human c3po complex 3.0Å AUTH X.YE,N.HUANG,Y.LIU,Z.PAROO,C.HUERTA,P.LI,S.CHEN,Q.LIU,AUTH 2 H.ZHANGTITL STRUCTURE OF C3PO AND MECHANISM OF HUMAN RISC ACTIVATION.REF NAT.STRUCT.MOL.BIOL. V. 18 650 2011REFN ISSN 1545-9993PMID 21552258DOI 10.1038/NSMB.2032 Variant Set Distributions Mapped Variants
General Structure Information 3qf2 NLRP3 crystal structure of nalp3 pyd 1.7Å AUTH J.Y.BAE,H.H.PARKTITL CRYSTAL STRUCTURE OF NALP3 PROTEIN PYRIN DOMAIN (PYD) ANDTITL 2 ITS IMPLICATIONS IN INFLAMMASOME ASSEMBLYREF J.BIOL.CHEM. V. 286 39528 2011REFN ISSN 0021-9258PMID 21880711DOI 10.1074/JBC.M111.278812 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ldq MRI1 crystal structure of the mediator of rho dependent invasion 2.5Å AUTH P.D.TEMPLETON,E.S.LITMAN,S.I.METZNER,N.G.AHN,M.C.SOUSATITL STRUCTURE OF MEDIATOR OF RHOA-DEPENDENT INVASION (MRDI)TITL 2 EXPLAINS ITS DUAL FUNCTION AS A METABOLIC ENZYME AND ATITL 3 MEDIATOR OF CELL INVASION.REF BIOCHEMISTRY V. 52 5675 2013REFN ISSN 0006-2960PMID 23859498DOI 10.1021/BI400556E Variant Set Distributions Mapped Variants
General Structure Information 2kg5 ARAP3 nmr solution structure of arap3-sam -1.0Å AUTH M.LEONE,J.CELLITTI,M.PELLECCHIATITL THE SAM DOMAIN OF THE LIPID PHOSPHATASE SHIP2TITL 2 ADOPTS A COMMON MODEL TO INTERACT WITH ARAP3-SAMTITL 3 AND EPHA2-SAM.REF BMC STRUCT.BIOL. V. 9 59 2009REFN ESSN 1472-6807PMID 19765305DOI 10.1186/1472-6807-9-59 Variant Set Distributions Mapped Variants
General Structure Information 3a98 DOCK2 crystal structure of the complex of the interacting regions of dock2 and elmo1 2.1Å AUTH K.HANAWA-SUETSUGU,M.KUKIMOTO-NIINO,C.MISHIMA-TSUMAGARI,AUTH 2 R.AKASAKA,N.OHSAWA,S.SEKINE,T.ITO,N.TOCHIO,S.KOSHIBA,AUTH 3 T.KIGAWA,T.TERADA,M.SHIROUZU,D.KOHDA,A.NISHIKIMI,Y.FUKUI,AUTH 4 S.YOKOYAMATITL STRUCTURAL BASIS OF FUNCTIONAL COMPLEX FORMATION BETWEENTITL 2 DOCK2 AND ELMO1 FOR RAC ACTIVATION IN LYMPHOCYTE CHEMOTAXISREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3a98 ELMO1 crystal structure of the complex of the interacting regions of dock2 and elmo1 2.1Å AUTH K.HANAWA-SUETSUGU,M.KUKIMOTO-NIINO,C.MISHIMA-TSUMAGARI,AUTH 2 R.AKASAKA,N.OHSAWA,S.SEKINE,T.ITO,N.TOCHIO,S.KOSHIBA,AUTH 3 T.KIGAWA,T.TERADA,M.SHIROUZU,D.KOHDA,A.NISHIKIMI,Y.FUKUI,AUTH 4 S.YOKOYAMATITL STRUCTURAL BASIS OF FUNCTIONAL COMPLEX FORMATION BETWEENTITL 2 DOCK2 AND ELMO1 FOR RAC ACTIVATION IN LYMPHOCYTE CHEMOTAXISREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3fo5 ACOT11 human start domain of acyl-coenzyme a thioesterase 11 (acot11) 2.0Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants