Assessment of Structural Intolerance and Durability
General Structure Information 2jw5 POLL polymerase lambda brct domain -1.0Å AUTH G.A.MUELLER,A.F.MOON,E.F.DEROSE,B.J.DAVIS,AUTH 2 D.A.RAMSDEN,L.C.PEDERSEN,R.E.LONDONTITL POLYMERASE LAMBDA BRCT DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fa2 BARD1 crystal structure of the brca1 associated ring domain (bard1) tandem brct domains 2.2Å AUTH D.FOX 3RD,I.LE TRONG,R.E.STENKAMP,R.E.KLEVITTITL CRYSTAL STRUCTURE OF THE BRCA1 ASSOCIATED RING DOMAINTITL 2 (BARD1) TANDEM BRCT DOMAINSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wf6 TOPBP1 the third brca1 c-terminus (brct) domain of similar to s.pombe rad4+/cut5+ product -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL THE THIRD BRCA1 C-TERMINUS (BRCT) DOMAIN OFTITL 2 SIMILAR TO S.POMBE RAD4+/CUT5+ PRODUCTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3pd7 TOPBP1 crystal structure of the sixth brct domain of human topbp1 1.26Å AUTH J.LEE,C.XU,G.CUI,J.R.THOMPSON,G.MERTITL CRYSTAL STRUCTURE OF THE SIXTH BRCT DOMAIN OF HUMAN TOPBP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3al2 TOPBP1 crystal structure of topbp1 brct7/8 2.0Å AUTH C.C.LEUNG,Z.GONG,J.CHEN,J.N.GLOVERTITL MOLECULAR BASIS OF BACH1/FANCJ RECOGNITION BY TOPBP1 IN DNATITL 2 REPLICATION CHECKPOINT CONTROLREF J.BIOL.CHEM. V. 286 4292 2011REFN ISSN 0021-9258PMID 21127055DOI 10.1074/JBC.M110.189555 Variant Set Distributions Mapped Variants
General Structure Information 3ueo TOPBP1 crystal structure of topbp1 brct4/5 domains in complex with a phospho- peptide 2.6Å AUTH C.C.LEUNG,L.SUN,Z.GONG,M.BURKAT,R.EDWARDS,M.ASSMUS,J.CHEN,AUTH 2 J.N.GLOVERTITL STRUCTURAL INSIGHTS INTO RECOGNITION OF MDC1 BY TOPBP1 INTITL 2 DNA REPLICATION CHECKPOINT CONTROL.REF STRUCTURE V. 21 1450 2013REFN ISSN 0969-2126PMID 23891287DOI 10.1016/J.STR.2013.06.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3sqd PAXIP1 crystal structure of human ptip brct5/6-gamma h2ax complex 2.15Å AUTH W.YAN,Z.H.SHAOTITL CRYSTAL STRUCTURE OF HUMAN PTIP BRCT5/6-GAMMA H2AXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3k05 MDC1 the crystal structure of mdc1 brct t2067d in complex with a minimal recognition tetrapeptide with an amidated c-terminus 1.33Å AUTH S.J.CAMPBELL,R.A.EDWARDS,J.N.GLOVERTITL COMPARISON OF THE STRUCTURES AND PEPTIDE BINDINGTITL 2 SPECIFICITIES OF THE BRCT DOMAINS OF MDC1 AND BRCA1REF STRUCTURE V. 18 167 2010REFN ISSN 0969-2126PMID 20159462DOI 10.1016/J.STR.2009.12.008 Variant Set Distributions […]
General Structure Information 3ii6 XRCC4 structure of human xrcc4 in complex with the tandem brct domains of dna ligaseiv. 2.4Å AUTH P.Y.WU,P.FRIT,S.MEESALA,S.DAUVILLIER,M.MODESTI,AUTH 2 S.N.ANDRES,Y.HUANG,J.SEKIGUCHI,P.CALSOU,B.SALLES,AUTH 3 M.S.JUNOPTITL STRUCTURAL AND FUNCTIONAL INTERACTION BETWEEN THETITL 2 HUMAN DNA REPAIR PROTEINS DNA LIGASE IV AND XRCC4REF MOL.CELL.BIOL. V. 11 3163 2009REFN ISSN 0270-7306PMID 19332554 Variant Set Distributions Mapped Variants
General Structure Information 3ii6 XRCC4 structure of human xrcc4 in complex with the tandem brct domains of dna ligaseiv. 2.4Å AUTH P.Y.WU,P.FRIT,S.MEESALA,S.DAUVILLIER,M.MODESTI,AUTH 2 S.N.ANDRES,Y.HUANG,J.SEKIGUCHI,P.CALSOU,B.SALLES,AUTH 3 M.S.JUNOPTITL STRUCTURAL AND FUNCTIONAL INTERACTION BETWEEN THETITL 2 HUMAN DNA REPAIR PROTEINS DNA LIGASE IV AND XRCC4REF MOL.CELL.BIOL. V. 11 3163 2009REFN ISSN 0270-7306PMID 19332554 Variant Set Distributions Mapped Variants