Assessment of Structural Intolerance and Durability
General Structure Information 2lt7 ZBTB33 solution nmr structure of kaiso zinc finger dna binding domain in complex with kaiso binding site dna -1.0Å AUTH B.A.BUCK-KOEHNTOP,R.L.STANFIELD,D.C.EKIERT,AUTH 2 M.A.MARTINEZ-YAMOUT,H.J.DYSON,I.A.WILSON,P.E.WRIGHTTITL MOLECULAR BASIS FOR RECOGNITION OF METHYLATED AND SPECIFICTITL 2 DNA SEQUENCES BY THE ZINC FINGER PROTEIN KAISO.REF PROC.NATL.ACAD.SCI.USA V. 109 15229 2012REFN ISSN 0027-8424PMID 22949637DOI 10.1073/PNAS.1213726109 Variant Set […]
General Structure Information 2dnh CELF5 solution structure of rna binding domain in bruno-like 5 rna binding protein -1.0Å AUTH K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN INTITL 2 BRUNO-LIKE 5 RNA BINDING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cq4 RBM23 solution structure of rna binding domain in rna binding motif protein 23 -1.0Å AUTH K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN IN RNATITL 2 BINDING MOTIF PROTEIN 23REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3lre KIF18A crystal structure analysis of human kinesin-8 motor domain 2.2Å AUTH C.PETERS,K.BREJC,L.BELMONT,A.J.BODEY,Y.LEE,M.YU,J.GUO,AUTH 2 R.SAKOWICZ,J.HARTMAN,C.A.MOORESTITL INSIGHT INTO THE MOLECULAR MECHANISM OF THE MULTITASKINGTITL 2 KINESIN-8 MOTOR.REF EMBO J. V. 29 3437 2010REFN ISSN 0261-4189PMID 20818331DOI 10.1038/EMBOJ.2010.220 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dnz RBM23 solution structure of the second rna binding domain of rna binding motif protein 23 -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND RNA BINDINGTITL 2 DOMAIN OF RNA BINDING MOTIF PROTEIN 23REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hf1 RRM2B crystal structure of human p53r2 2.6Å AUTH P.SMITH,B.ZHOU,N.HO,Y.C.YUAN,L.SU,S.C.TSAI,Y.YENTITL 2.6 A X-RAY CRYSTAL STRUCTURE OF HUMAN P53R2, ATITL 2 P53-INDUCIBLE RIBONUCLEOTIDE REDUCTASE .REF BIOCHEMISTRY V. 48 11134 2009REFN ISSN 0006-2960PMID 19728742DOI 10.1021/BI9001425 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ndy APITD1 human mhf1-mhf2 dna complex 7.0Å AUTH Q.ZHAO,D.SARO,A.SACHPATZIDIS,T.R.SINGH,D.SCHLINGMAN,AUTH 2 X.F.ZHENG,A.MACK,M.S.TSAI,S.MOCHRIE,L.REGAN,A.R.MEETEI,AUTH 3 P.SUNG,Y.XIONGTITL THE MHF COMPLEX SENSES BRANCHED DNA BY BINDING A PAIR OFTITL 2 CROSSOVER DNA DUPLEXES.REF NAT COMMUN V. 5 2987 2014REFN ESSN 2041-1723PMID 24390579DOI 10.1038/NCOMMS3987 Variant Set Distributions Mapped Variants
General Structure Information 2daz INADL solution structure of the 7th pdz domain of inad-like protein -1.0Å AUTH K.INOUE,T.NAGASHIMA,K.IZUMI,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 7TH PDZ DOMAIN OFTITL 2 INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vkc N4BP2 solution structure of the b3bp smr domain -1.0Å AUTH T.DIERCKS,E.AB,M.A.DANIELS,R.N.DE JONG,R.BESSELING,AUTH 2 R.KAPTEIN,G.E.FOLKERSTITL SOLUTION STRUCTURE AND CHARACTERIZATION OF THETITL 2 DNA- BINDING ACTIVITY OF THE B3BP-SMR DOMAIN.REF J.MOL.BIOL. V. 383 1156 2008REFN ISSN 0022-2836PMID 18804481DOI 10.1016/J.JMB.2008.09.005 Variant Set Distributions Mapped Variants
General Structure Information 4ndg APTX human aprataxin (aptx) bound to rna-dna and zn – adenosine vanadate transition state mimic complex 2.54Å AUTH P.TUMBALE,J.S.WILLIAMS,M.J.SCHELLENBERG,T.A.KUNKEL,AUTH 2 R.S.WILLIAMSTITL APRATAXIN RESOLVES ADENYLATED RNA-DNA JUNCTIONS TO MAINTAINTITL 2 GENOME INTEGRITY.REF NATURE V. 506 111 2013REFN ISSN 0028-0836PMID 24362567DOI 10.1038/NATURE12824 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants