Assessment of Structural Intolerance and Durability
General Structure Information 2ysx INPP5D solution structure of the human ship sh2 domain -1.0Å AUTH T.KASAI,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN SHIP SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3sde PSPC1 crystal structure of a paraspeckle-protein heterodimer, pspc1/nono 1.9Å AUTH D.M.PASSON,M.LEE,O.RACKHAM,W.A.STANLEY,A.SADOWSKA,AUTH 2 A.FILIPOVSKA,A.H.FOX,C.S.BONDTITL STRUCTURE OF THE HETERODIMER OF HUMAN NONO AND PARASPECKLETITL 2 PROTEIN COMPONENT 1 AND ANALYSIS OF ITS ROLE IN SUBNUCLEARTITL 3 BODY FORMATION.REF PROC.NATL.ACAD.SCI.USA V. 109 4846 2012REFN ISSN 0027-8424PMID 22416126DOI 10.1073/PNAS.1120792109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3o3i PIWIL1 crystal structure of human hiwi1 paz domain (residues 277-399) in complex with 14-mer rna (12-bp + 2-nt overhang) containing 2-oh at its 3-end 2.8Å AUTH Y.TIAN,D.K.SIMANSHU,J.B.MA,D.J.PATELTITL INAUGURAL ARTICLE: STRUCTURAL BASIS FOR PIRNATITL 2 2-O-METHYLATED 3-END RECOGNITION BY PIWI PAZTITL 3 (PIWI/ARGONAUTE/ZWILLE) DOMAINS.REF PROC.NATL.ACAD.SCI.USA V. 108 903 2011REFN ISSN 0027-8424PMID 21193640DOI […]
General Structure Information 4n4f CREBBP crystal structure of the bromodomain-phd finger module of human transcriptional co-activator cbp in complex with di-acetylated histone 4 peptide (h412ack16ac). 1.83Å AUTH A.N.PLOTNIKOV,S.YANG,T.J.ZHOU,E.RUSINOVA,A.FRASCA,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO ACETYLATED-HISTONE H4 RECOGNITIONTITL 2 BY THE BROMODOMAIN-PHD FINGER MODULE OF HUMANTITL 3 TRANSCRIPTIONAL COACTIVATOR CBP.REF STRUCTURE V. 22 353 2014REFN ISSN 0969-2126PMID 24361270DOI 10.1016/J.STR.2013.10.021 […]
General Structure Information 2i46 ACD crystal structure of human tpp1 2.7Å AUTH F.WANG,E.R.PODELL,A.J.ZAUG,Y.YANG,P.BACIU,T.R.CECH,AUTH 2 M.LEITITL THE POT1-TPP1 TELOMERE COMPLEX IS A TELOMERASETITL 2 PROCESSIVITY FACTOR.REF NATURE V. 445 506 2007REFN ISSN 0028-0836PMID 17237768DOI 10.1038/NATURE05454 Variant Set Distributions Mapped Variants
General Structure Information 2wh5 ACBD4 crystal structure of human acyl-coa binding domain 4 complexed with stearoyl-coa 2.6Å AUTH N.SHAFQAT,W.W.YUE,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN ACYL-COA BINDING DOMAINTITL 2 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hwx SMG6 structure of human smg6 e1282c pin domain mutant. 1.9Å AUTH F.GLAVAN,I.BEHM-ANSMANT,E.IZAURRALDE,E.CONTITITL STRUCTURES OF THE PIN DOMAINS OF SMG6 AND SMG5TITL 2 REVEAL A NUCLEASE WITHIN THE MRNA SURVEILLANCETITL 3 COMPLEX.REF EMBO J. V. 25 5117 2006REFN ISSN 0261-4189PMID 17053788DOI 10.1038/SJ.EMBOJ.7601377 Variant Set Distributions Mapped Variants
General Structure Information 1mp1 SRRM1 solution structure of the pwi motif from srm160 -1.0Å AUTH B.R.SZYMCZYNA,J.BOWMAN,S.MCCRACKEN,A.PINEDA-LUCENA,AUTH 2 Y.LU,B.COX,M.LAMBERMON,B.R.GRAVELEY,C.H.ARROWSMITH,AUTH 3 B.J.BLENCOWETITL STRUCTURE AND FUNCTION OF THE PWI MOTIF: A NOVELTITL 2 NUCLEIC ACID-BINDING DOMAIN THAT FACILITATESTITL 3 PRE-MRNA PROCESSING.REF GENES DEV. V. 17 461 2003REFN ISSN 0890-9369PMID 12600940DOI 10.1101/GAD.1060403 Variant Set Distributions Mapped Variants
General Structure Information 2aft SUMF1 formylglycine generating enzyme c336s mutant 1.66Å AUTH D.ROESER,A.PREUSSER-KUNZE,B.SCHMIDT,K.GASOW,J.G.WITTMANN,AUTH 2 T.DIERKS,K.VON FIGURA,M.G.RUDOLPHTITL A GENERAL BINDING MECHANISM FOR ALL HUMAN SULFATASES BY THETITL 2 FORMYLGLYCINE-GENERATING ENZYMEREF PROC.NATL.ACAD.SCI.USA V. 103 81 2006REFN ISSN 0027-8424PMID 16368756DOI 10.1073/PNAS.0507592102 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ii7 KLHL7 crystal structure of the kelch domain of human klhl7 1.63Å AUTH P.CANNING,C.D.COOPER,T.KROJER,J.W.MURRAY,A.C.PIKE,AUTH 2 A.CHAIKUAD,T.KEATES,C.THANGARATNARAJAH,V.HOJZAN,AUTH 3 V.AYINAMPUDI,B.D.MARSDEN,O.GILEADI,S.KNAPP,F.VON DELFT,AUTH 4 A.N.BULLOCKTITL STRUCTURAL BASIS FOR CUL3 PROTEIN ASSEMBLY WITH THETITL 2 BTB-KELCH FAMILY OF E3 UBIQUITIN LIGASES.REF J.BIOL.CHEM. V. 288 7803 2013REFN ISSN 0021-9258PMID 23349464DOI 10.1074/JBC.M112.437996 Variant Set Distributions Ripley’s K Analysis Plots […]