Assessment of Structural Intolerance and Durability
General Structure Information 2m3o NEDD4 structure and dynamics of a human nedd4 ww domain-enac complex -1.0Å AUTH R.BOBBY,K.MEDINI,P.NEUDECKER,T.V.LEE,M.A.BRIMBLE,AUTH 2 F.J.MCDONALD,J.S.LOTT,A.J.DINGLEYTITL STRUCTURE AND DYNAMICS OF HUMAN NEDD4-1 WW3 IN COMPLEX WITHTITL 2 THE ALPHA ENAC PY MOTIF.REF BIOCHIM.BIOPHYS.ACTA V.1834 1632 2013REFN ISSN 0006-3002PMID 23665454DOI 10.1016/J.BBAPAP.2013.04.031 Variant Set Distributions Mapped Variants
General Structure Information 2xbb NEDD4 nedd4 hect:ub complex 2.68Å AUTH E.MASPERO,S.MARI,E.VALENTINI,A.MUSACCHIO,A.FISH,AUTH 2 S.PASQUALATO,S.POLOTITL STRUCTURE OF THE HECT:UBIQUITIN COMPLEX AND ITS ROLE INTITL 2 UBIQUITIN CHAIN ELONGATIONREF EMBO REP. V. 12 342 2011REFN ISSN 1469-221XPMID 21399620DOI 10.1038/EMBOR.2011.21 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3law RAB7A structure of gtp-bound l129f mutant rab7 2.8Å AUTH B.A.MCCRAY,E.SKORDALAKES,J.P.TAYLORTITL DISEASE MUTATIONS IN RAB7 RESULT IN UNREGULATED NUCLEOTIDETITL 2 EXCHANGE AND INAPPROPRIATE ACTIVATION.REF HUM.MOL.GENET. V. 19 1033 2010REFN ISSN 0964-6906PMID 20028791DOI 10.1093/HMG/DDP567 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3v53 RBM25 crystal structure of human rbm25 2.9Å AUTH D.S.GONG,F.YANG,F.LI,D.QIAN,M.WU,Z.SHAO,M.WU,J.WU,Y.SHITITL CRYSTAL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THETITL 2 HUMAN RBM25 PWI DOMAIN AND ITS FLANKING BASIC REGIONREF BIOCHEM.J. V. 450 85 2013REFN ISSN 0264-6021PMID 23190262DOI 10.1042/BJ20121382 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1toz NOTCH1 nmr structure of the human notch-1 ligand binding region -1.0Å AUTH S.HAMBLETON,N.V.VALEYEV,A.MURANYI,V.KNOTT,AUTH 2 J.M.WERNER,A.J.MCMICHAEL,P.A.HANDFORD,A.K.DOWNINGTITL STRUCTURAL AND FUNCTIONAL PROPERTIES OF THE HUMANTITL 2 NOTCH-1 LIGAND BINDING REGIONREF STRUCTURE V. 12 2173 2004REFN ISSN 0969-2126PMID 15576031DOI 10.1016/J.STR.2004.09.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2do0 HNRNPM solution structure of the rna binding domain of heterogeneous nuclear ribonucleoprotein m -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA BINDING DOMAIN OFTITL 2 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN MREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4n3b HCFC1 crystal structure of human o-glcnac transferase bound to a peptide from hcf-1 pro-repeat2(1-26)e10q and udp-5sglcnac 2.17Å AUTH M.B.LAZARUS,J.JIANG,V.KAPURIA,T.BHUIYAN,J.JANETZKO,AUTH 2 W.F.ZANDBERG,D.J.VOCADLO,W.HERR,S.WALKERTITL HCF-1 IS CLEAVED IN THE ACTIVE SITE OF O-GLCNAC TRANSFERASE.REF SCIENCE V. 342 1235 2013REFN ISSN 0036-8075PMID 24311690DOI 10.1126/SCIENCE.1243990 Variant Set Distributions Mapped Variants
General Structure Information 2kg1 HNRNPF structure of the third qrrm domain of hnrnp f in complex with a agggau g-tract rna -1.0Å AUTH C.DOMINGUEZ,J.F.FISETTE,B.CHABOT,F.H.ALLAINTITL STRUCTURAL BASIS OF G-TRACT RECOGNITION AND ENCAGING BYTITL 2 HNRNP F QUASI-RRMS.REF NAT.STRUCT.MOL.BIOL. V. 17 853 2010REFN ISSN 1545-9993PMID 20526337DOI 10.1038/NSMB.1814 Variant Set Distributions Mapped Variants
General Structure Information 3hy4 MTHFS structure of human mthfs with n5-iminium phosphate 2.79Å AUTH D.WU,Y.LI,G.SONG,C.CHENG,R.ZHANG,A.JOACHIMIAK,AUTH 2 N.SHAW,Z.-J.LIUTITL STRUCTURAL BASIS FOR THE INHIBITION OF HUMANTITL 2 5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE BYTITL 3 N10-SUBSTITUTED FOLATE ANALOGUESREF CANCER RES. V. 69 7294 2009REFN ISSN 0008-5472PMID 19738041DOI 10.1158/0008-5472.CAN-09-1927 Variant Set Distributions Mapped Variants
General Structure Information 3o8v FXR1 crystal structure of the tudor domains from fxr1 2.5Å AUTH M.A.ADAMS-CIOABA,Y.GUO,C.BIAN,M.F.AMAYA,R.LAM,G.A.WASNEY,AUTH 2 M.VEDADI,C.XU,J.MINTITL STRUCTURAL STUDIES OF THE TANDEM TUDOR DOMAINS OF FRAGILE XTITL 2 MENTAL RETARDATION RELATED PROTEINS FXR1 AND FXR2.REF PLOS ONE V. 5 E1355 2010REFN ESSN 1932-6203PMID 21072162DOI 10.1371/JOURNAL.PONE.0013559 Variant Set Distributions Mapped Variants