General Structure Information
| PDB ID | 1toz |
| HGNC Gene Label(s) | NOTCH1 |
| Structure Name | nmr structure of the human notch-1 ligand binding region |
| Resolution | -1.0Å |
| Reference | AUTH S.HAMBLETON,N.V.VALEYEV,A.MURANYI,V.KNOTT,AUTH 2 J.M.WERNER,A.J.MCMICHAEL,P.A.HANDFORD,A.K.DOWNINGTITL STRUCTURAL AND FUNCTIONAL PROPERTIES OF THE HUMANTITL 2 NOTCH-1 LIGAND BINDING REGIONREF STRUCTURE V. 12 2173 2004REFN ISSN 0969-2126PMID 15576031DOI 10.1016/J.STR.2004.09.012 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 116 |
| Number Of SNVs | 23 |
| Number Of Permutations | 15010 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.024 |
| p-value | 0.802 |
COSMIC
| Number Of Residues | 116 |
| Number Of SNVs | 10 |
| Number Of Permutations | 2477 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.467 |
| p-value | 0.061 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 23 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.08 |
| p-value | 0.306 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
