Assessment of Structural Intolerance and Durability
General Structure Information 2kwo HIST1H4F solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 2kwo HIST1H4H solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 2kwo HIST1H4C solution structure of the double phd (plant homeodomain) fingers of human transcriptional protein dpf3b bound to a histone h4 peptide containing n-terminal acetylation at serine 1 -1.0Å AUTH L.ZENG,Q.ZHANG,S.LI,A.N.PLOTNIKOV,M.J.WALSH,M.M.ZHOUTITL MECHANISM AND REGULATION OF ACETYLATED HISTONE BINDING BYTITL 2 THE TANDEM PHD FINGER OF DPF3B.REF NATURE V. 466 258 2010REFN ISSN […]
General Structure Information 4guk NCS1 new crystal form structure of human ncs1 1.75Å AUTH F.CHENGPENG,L.ELIASTITL NEW CRYSTAL FORM STRUCTURE OF HUMAN NCS1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qkq EPHB4 structure of the sam domain of human ephrin type-b receptor 4 2.1Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL SAM DOMAIN OF HUMAN EPHRIN TYPE-B RECEPTOR 4TITL 2 (EPHB4)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1z29 SULT1A2 crystal structures of sult1a2 and sult1a1*3: implications in the bioactivation of n-hydroxy-2-acetylamino fluorine (oh-aaf) 2.4Å AUTH J.LU,H.LI,J.ZHANG,M.LI,M.Y.LIU,X.AN,M.C.LIU,W.CHANGTITL CRYSTAL STRUCTURES OF SULT1A2 AND SULT1A1 *3: INSIGHTS INTOTITL 2 THE SUBSTRATE INHIBITION AND THE ROLE OF TYR149 IN SULT1A2.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 396 429 2010REFN ISSN 0006-291XPMID 20417180DOI 10.1016/J.BBRC.2010.04.109 Variant Set Distributions Ripley’s […]
General Structure Information 2grc SMARCA4 1.5 a structure of bromodomain from human brg1 protein, a central atpase of swi/snf remodeling complex 1.5Å AUTH M.SINGH,G.M.POPOWICZ,M.KRAJEWSKI,T.A.HOLAKTITL STRUCTURAL RAMIFICATION FOR ACETYL-LYSINETITL 2 RECOGNITION BY THE BROMODOMAIN OF HUMAN BRG1TITL 3 PROTEIN, A CENTRAL ATPASE OF THE SWI/SNFTITL 4 REMODELING COMPLEX.REF CHEMBIOCHEM V. 8 1308 2007REFN ISSN 1439-4227PMID 17582821DOI […]
General Structure Information 1pve RAD23B solution structure of xpc binding domain of hhr23b -1.0Å AUTH B.KIM,K.S.RYU,H.J.KIM,S.J.CHO,B.S.CHOITITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THETITL 2 XPC-BINDING DOMAIN OF THE HUMAN DNA REPAIR PROTEINTITL 3 HHR23B.REF FEBS J. V. 272 2467 2005REFN ISSN 1742-464XPMID 15885096DOI 10.1111/J.1742-4658.2005.04667.X Variant Set Distributions Mapped Variants
General Structure Information 2qkh GIPR crystal structure of the extracellular domain of human gip receptor in complex with the hormone gip 1.9Å AUTH C.PARTHIER,M.KLEINSCHMIDT,P.NEUMANN,R.RUDOLPH,AUTH 2 S.MANHART,D.SCHLENZIG,J.FANGHANEL,J.-U.RAHFELD,AUTH 3 H.-U.DEMUTH,M.T.STUBBSTITL CRYSTAL STRUCTURE OF THE INCRETIN-BOUNDTITL 2 EXTRACELLULAR DOMAIN OF A G PROTEIN-COUPLEDTITL 3 RECEPTORREF PROC.NATL.ACAD.SCI.USA V. 104 13942 2007REFN ISSN 0027-8424PMID 17715056DOI 10.1073/PNAS.0706404104 Variant Set Distributions Ripley’s […]
General Structure Information 4nie RORC crystal structure of the orphan nuclear receptor ror(gamma)t ligand- binding domain in complex with small molecule ligand 2.01Å AUTH T.YANG,L.QIAN,Y.B.CHENG,W.CAI,Y.L.MA,L.Q.YANG,Q.Q.WU,AUTH 2 L.A.ORBAND-MILLER,L.ZHOU,M.HUXDORF,W.ZHANG,J.ZHANG,AUTH 3 J.N.XIANG,S.LEUNG,Y.QIU,Z.ZHONG,J.D.ELLIOT,X.C.LIN,Y.H.WANGTITL DISCOVERY OF TERTIARY AMINE AND INDOLE DERIVATIVES AS POTENTTITL 2 ROR-GAMMA-T INVERSE AGONISTSREF ACS MED.CHEM.LETT. 2013REFN ISSN 1948-5875DOI 10.1021/ML4003875 Variant Set Distributions Ripley’s K Analysis Plots […]