Assessment of Structural Intolerance and Durability
General Structure Information 2dt7 SF3A3 solution structure of the second surp domain of human splicing factor sf3a120 in complex with a fragment of human splicing factor sf3a60 -1.0Å AUTH K.KUWASAKO,F.HE,M.INOUE,A.TANAKA,S.SUGANO,AUTH 2 P.GUENTERT,Y.MUTO,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SURP DOMAINS AND THETITL 2 SUBUNIT-ASSEMBLY MECHANISM WITHIN THE SPLICINGTITL 3 FACTOR SF3A COMPLEX IN 17S U2 SNRNPREF STRUCTURE […]
General Structure Information 2enz PRKCQ solution structure of the second c1 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND C1 DOMAIN FROMTITL 2 HUMAN PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ha8 TARBP1 methyltransferase domain of human tar (hiv-1) rna binding protein 1 1.6Å AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,K.BATTAILE,J.WEIGELT,AUTH 2 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN TAR (HIV-1) RNA BINDING PROTEIN 1 INTITL 3 COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3com STK4 crystal structure of mst1 kinase 2.2Å AUTH S.ATWELL,S.K.BURLEY,M.DICKEY,B.LEON,J.M.SAUDERTITL CRYSTAL STRUCTURE OF MST1 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3vyx DHX9 structural insights into risc assembly facilitated by dsrna binding domains of human rna helicase (dhx9) 2.29Å AUTH Q.FU,Y.A.YUANTITL STRUCTURAL INSIGHTS INTO RISC ASSEMBLY FACILITATED BYTITL 2 DSRNA-BINDING DOMAINS OF HUMAN RNA HELICASE A (DHX9)REF NUCLEIC ACIDS RES. 2013REFN ESSN 1362-4962PMID 23361462DOI 10.1093/NAR/GKT042 Variant Set Distributions Mapped Variants
General Structure Information 2qnd FMR1 crystal structure of the kh1-kh2 domains from human fragile x mental retardation protein 1.9Å AUTH R.VALVERDE,I.POZDNYAKOVA,T.KAJANDER,J.VENKATRAMAN,L.REGANTITL FRAGILE X MENTAL RETARDATION SYNDROME: STRUCTURE OF THETITL 2 KH1-KH2 DOMAINS OF FRAGILE X MENTAL RETARDATION PROTEIN.REF STRUCTURE V. 15 1090 2007REFN ISSN 0969-2126PMID 17850748DOI 10.1016/J.STR.2007.06.022 Variant Set Distributions Mapped Variants
General Structure Information 2kmv ATP7A solution structure of the nucleotide binding domain of the human menkes protein in the atp-free form -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,S.INAGAKI,M.MIGLIARDI,AUTH 2 A.ROSATOTITL THE BINDING MODE OF ATP REVEALED BY THE SOLUTIONTITL 2 STRUCTURE OF THE N-DOMAIN OF HUMAN ATP7A.REF J.BIOL.CHEM. 2009REFN ESSN 1083-351XPMID 19917612DOI 10.1074/JBC.M109.054262 Variant Set Distributions Mapped Variants
General Structure Information 4hmy AP1B1 structural basis for recruitment and activation of the ap-1 clathrin adaptor complex by arf1 7.0Å AUTH X.REN,G.G.FARIAS,B.J.CANAGARAJAH,J.S.BONIFACINO,J.H.HURLEYTITL STRUCTURAL BASIS FOR RECRUITMENT AND ACTIVATION OF THE AP-1TITL 2 CLATHRIN ADAPTOR COMPLEX BY ARF1.REF CELL(CAMBRIDGE,MASS.) V. 152 755 2013REFN ISSN 0092-8674PMID 23415225DOI 10.1016/J.CELL.2012.12.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2f6n BPTF crystal structure of phd finger-linker-bromodomain fragment of human bptf in the free form 2.0Å AUTH H.LI,S.ILIN,W.WANG,E.M.DUNCAN,J.WYSOCKA,C.D.ALLIS,AUTH 2 D.J.PATELTITL MOLECULAR BASIS FOR SITE-SPECIFIC READ-OUT OFTITL 2 HISTONE H3K4ME3 BY THE BPTF PHD FINGER OF NURF.REF NATURE V. 442 91 2006REFN ISSN 0028-0836PMID 16728978DOI 10.1038/NATURE04802 Variant Set Distributions Mapped Variants
General Structure Information 1j8e LRP1 crystal structure of ligand-binding repeat cr7 from lrp 1.85Å AUTH M.SIMONOVIC,K.DOLMER,W.HUANG,D.K.STRICKLAND,K.VOLZ,AUTH 2 P.G.GETTINSTITL CALCIUM COORDINATION AND PH DEPENDENCE OF THETITL 2 CALCIUM AFFINITY OF LIGAND-BINDING REPEAT CR7 FROMTITL 3 THE LRP. COMPARISON WITH RELATED DOMAINS FROM THETITL 4 LRP AND THE LDL RECEPTOR.REF BIOCHEMISTRY V. 40 15127 2001REFN ISSN 0006-2960PMID […]