Assessment of Structural Intolerance and Durability
General Structure Information 4azm FABP5 human epidermal fatty acid-binding protein (fabp5) in complex with the inhibitor bms-309413 2.75Å AUTH B.SANSON,T.WANG,J.SUN,L.WANG,M.KACZOCHA,I.OJIMA,D.DEUTSCH,AUTH 2 H.LITITL CRYSTALLOGRAPHIC STUDY OF FABP5 AS AN INTRACELLULARTITL 2 ENDOCANNABINOID TRANSPORTER.REF ACTA CRYSTALLOGR.,SECT.D V. 70 290 2014REFN ISSN 0907-4449PMID 24531463DOI 10.1107/S1399004713026795 Variant Set Distributions Mapped Variants
General Structure Information 1aqc APBA1 x11 ptb domain-10mer peptide complex 2.3Å AUTH Z.ZHANG,C.H.LEE,V.MANDIYAN,J.P.BORG,B.MARGOLIS,AUTH 2 J.SCHLESSINGER,J.KURIYANTITL SEQUENCE-SPECIFIC RECOGNITION OF THETITL 2 INTERNALIZATION MOTIF OF THE ALZHEIMERS AMYLOIDTITL 3 PRECURSOR PROTEIN BY THE X11 PTB DOMAIN.REF EMBO J. V. 16 6141 1997REFN ISSN 0261-4189PMID 9321393DOI 10.1093/EMBOJ/16.20.6141 Variant Set Distributions Mapped Variants
General Structure Information 2e50 SET crystal structure of set/taf-1beta/inhat 2.3Å AUTH S.MUTO,M.SENDA,Y.AKAI,L.SATO,T.SUZUKI,R.NAGAI,T.SENDA,AUTH 2 M.HORIKOSHITITL RELATIONSHIP BETWEEN THE STRUCTURE OF SET/TAF-IBETA/INHATTITL 2 AND ITS HISTONE CHAPERONE ACTIVITYREF PROC.NATL.ACAD.SCI.USA V. 104 4285 2007REFN ISSN 0027-8424PMID 17360516DOI 10.1073/PNAS.0603762104 Variant Set Distributions Mapped Variants
General Structure Information 4gt4 ROR2 structure of unliganded, inactive ror2 kinase domain 2.41Å AUTH S.C.ARTIM,J.M.MENDROLA,M.A.LEMMONTITL ASSESSING THE RANGE OF KINASE AUTOINHIBITION MECHANISMS INTITL 2 THE INSULIN RECEPTOR FAMILY.REF BIOCHEM.J. V. 448 213 2012REFN ISSN 0264-6021PMID 22992069DOI 10.1042/BJ20121365 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ukl SREBF2 crystal structure of importin-beta and srebp-2 complex 3.0Å AUTH S.J.LEE,T.SEKIMOTO,E.YAMASHITA,E.NAGOSHI,AUTH 2 A.NAKAGAWA,N.IMAMOTO,M.YOSHIMURA,H.SAKAI,K.T.CHONG,AUTH 3 T.TSUKIHARA,Y.YONEDATITL THE STRUCTURE OF IMPORTIN-BETA BOUND TO SREBP-2:TITL 2 NUCLEAR IMPORT OF A TRANSCRIPTION FACTORREF SCIENCE V. 302 1571 2003REFN ISSN 0036-8075PMID 14645851DOI 10.1126/SCIENCE.1088372 Variant Set Distributions Mapped Variants
General Structure Information 3bpr MERTK crystal structure of catalytic domain of the proto-oncogene tyrosine- protein kinase mer in complex with inhibitor c52 2.8Å AUTH X.HUANG,P.FINERTY,J.R.WALKER,C.BUTLER-COLE,M.VEDADI,AUTH 2 M.SCHAPIRA,S.A.PARKER,B.E.TURK,D.A.THOMPSON,S.DHE-PAGANONTITL STRUCTURAL INSIGHTS INTO THE INHIBITED STATES OF THE MERTITL 2 RECEPTOR TYROSINE KINASE.REF J.STRUCT.BIOL. V. 165 88 2009REFN ISSN 1047-8477PMID 19028587DOI 10.1016/J.JSB.2008.10.003 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3ll8 PPP3CA crystal structure of calcineurin in complex with akap79 peptide 2.0Å AUTH H.LI,M.D.PINK,J.G.MURPHY,A.STEIN,M.L.DELLACQUA,P.G.HOGANTITL BALANCED INTERACTIONS OF CALCINEURIN WITH AKAP79 REGULATETITL 2 CA(2+)-CALCINEURIN-NFAT SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 19 337 2012REFN ISSN 1545-9993PMID 22343722DOI 10.1038/NSMB.2238 Variant Set Distributions Mapped Variants
General Structure Information 1uv0 REG3A pancreatitis-associated protein 1 from human 1.78Å AUTH C.ABERGEL,S.CHENIVESSE,M.G.STINNAKRE,S.GUASCO,C.BRECHOT,AUTH 2 J.M.CLAVERIE,E.DEVINOY,L.CHRISTATITL CRYSTALLIZATION AND PRELIMINARY CRYSTALLOGRAPHIC STUDY OFTITL 2 HIP/PAP, A HUMAN C-LECTIN OVEREXPRESSED IN PRIMARY LIVERTITL 3 CANCERS.REF ACTA CRYSTALLOGR.,SECT.D V. 55 1487 1999REFN ISSN 0907-4449PMID 10417404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2dh7 TIAL1 solution structure of the second rna binding domain in nucleolysin tiar -1.0Å AUTH T.IMAI,K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND RNA BINDINGTITL 2 DOMAIN IN NUCLEOLYSIN TIARREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2la5 FMR1 rna duplex-quadruplex junction complex with fmrp rgg peptide -1.0Å AUTH A.T.PHAN,V.KURYAVYI,J.C.DARNELL,A.SERGANOV,A.MAJUMDAR,AUTH 2 S.ILIN,T.RASLIN,A.POLONSKAIA,C.CHEN,D.CLAIN,R.B.DARNELL,AUTH 3 D.J.PATELTITL STRUCTURE-FUNCTION STUDIES OF FMRP RGG PEPTIDE RECOGNITIONTITL 2 OF AN RNA DUPLEX-QUADRUPLEX JUNCTION.REF NAT.STRUCT.MOL.BIOL. V. 18 796 2011REFN ISSN 1545-9993PMID 21642970DOI 10.1038/NSMB.2064 Variant Set Distributions Mapped Variants