Assessment of Structural Intolerance and Durability
General Structure Information 2d8r THAP2 solution structure of the thap domain of the human thap domain-containing protein 2 -1.0Å AUTH K.MIYAMOTO,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THAP DOMAIN OF THE HUMANTITL 2 THAP DOMAIN-CONTAINING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1xcr C11orf54 crystal structure of longer splice variant of ptd012 from homo sapiens reveals a novel zinc-containing fold 1.7Å AUTH B.A.MANJASETTY,K.BUESSOW,M.FIEBER-ERDMANN,Y.ROSKE,J.GOBOM,AUTH 2 C.SCHEICH,F.GOETZ,F.H.NIESEN,U.HEINEMANNTITL CRYSTAL STRUCTURE OF HOMO SAPIENS PTD012 REVEALS ATITL 2 ZINC-CONTAINING HYDROLASE FOLDREF PROTEIN SCI. V. 15 914 2006REFN ISSN 0961-8368PMID 16522806DOI 10.1110/PS.052037006 Variant Set Distributions Mapped Variants
General Structure Information 2k2d RCHY1 solution nmr structure of c-terminal domain of human pirh2. northeast structural genomics consortium (nesg) target ht2c -1.0Å AUTH Y.SHENG,R.C.LAISTER,A.LEMAK,B.WU,E.TAI,S.DUAN,AUTH 2 J.LUKIN,M.SUNNERHAGEN,S.SRISAILAM,M.KARRA,AUTH 3 S.BENCHIMOL,C.H.ARROWSMITHTITL MOLECULAR BASIS OF PIRH2-MEDIATED P53TITL 2 UBIQUITYLATION.REF NAT.STRUCT.MOL.BIOL. V. 15 1334 2008REFN ISSN 1545-9993PMID 19043414DOI 10.1038/NSMB.1521 Variant Set Distributions Mapped Variants
General Structure Information 2l4m ZBP1 solution structure of the zbeta domain of human dai and its binding modes to b- and z-dna -1.0Å AUTH K.KIM,B.KHAYRUTDINOV,C.-K.LEE,H.-K.CHEONG,S.KANG,H.PARK,AUTH 2 S.LEE,Y.-G.KIM,J.-G.JEE,A.RICH,K.K.KIM,Y.H.JEONTITL SOLUTION STRUCTURE OF THE ZBETA DOMAIN OF HUMANTITL 2 DNA-DEPENDENT ACTIVATOR OF IFN-REGULATORY FACTORS AND ITSTITL 3 BINDING MODES TO B- AND Z-DNAREF PROC.NATL.ACAD.SCI.USA 2011REFN ESSN 1091-6490 Variant […]
General Structure Information 3kvh NUDT16L1 crystal structure of human protein syndesmos (nudt16-like protein) 1.7Å AUTH L.TRESAUGUES,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 4 T.KARLBERG,T.KOTENYOVA,A.KOTZSCH,P.KRAULIS,M.MOCHE,AUTH 5 T.K.NIELSEN,T.NYMAN,C.PERSSON,A.K.ROOS,H.SCHULER,P.SCHUTZ,AUTH 6 A.G.THORSELL,S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN PROTEIN SYNDESMOS (NUDT16L1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dmy STRBP solution structure of dsrm domain in spermatid perinuclear rna-bind protein -1.0Å AUTH S.KADIRVEL,F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,AUTH 2 T.TERADA,S.YOKOYAMATITL SOLUTION STRUCTURE OF DSRM DOMAIN IN SPERMATIDTITL 2 PERINUCLEAR RNA-BIND PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yse MAGI1 solution structure of the second ww domain from the human membrane-associated guanylate kinase, ww and pdz domain- containing protein 1. magi-1 -1.0Å AUTH S.OHNISHI,M.SATO,S.KOSHIBA,T.HARADA,S.WATANABE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND WW DOMAIN FROMTITL 2 THE HUMAN MEMBRANE-ASSOCIATED GUANYLATE KINASE, WWTITL 3 AND PDZ DOMAIN-CONTAINING PROTEIN 1. MAGI-1REF TO BE […]
General Structure Information 1r42 ACE2 native human angiotensin converting enzyme-related carboxypeptidase (ace2) 2.2Å AUTH P.TOWLER,B.STAKER,S.G.PRASAD,S.MENON,J.TANG,T.PARSONS,AUTH 2 D.RYAN,M.FISHER,D.WILLIAMS,N.A.DALES,M.A.PATANE,AUTH 3 M.W.PANTOLIANOTITL ACE2 X-RAY STRUCTURES REVEAL A LARGE HINGE-BENDING MOTIONTITL 2 IMPORTANT FOR INHIBITOR BINDING AND CATALYSIS.REF J.BIOL.CHEM. V. 279 17996 2004REFN ISSN 0021-9258PMID 14754895DOI 10.1074/JBC.M311191200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4m6w C19orf40 crystal structure of the c-terminal segment of fancm in complex with faap24 2.9Å AUTH H.YANG,T.ZHANG,Y.TAO,F.WANG,L.TONG,J.DINGTITL STRUCTURAL INSIGHTS INTO THE FUNCTIONS OF THE FANCM-FAAP24TITL 2 COMPLEX IN DNA REPAIR.REF NUCLEIC ACIDS RES. V. 41 10573 2013REFN ISSN 0305-1048PMID 24003026DOI 10.1093/NAR/GKT788 Variant Set Distributions Mapped Variants
General Structure Information 2k2c RCHY1 solution nmr structure of n-terminal domain of human pirh2. northeast structural genomics consortium (nesg) target ht2a -1.0Å AUTH Y.SHENG,R.C.LAISTER,A.LEMAK,B.WU,E.TAI,S.DUAN,AUTH 2 J.LUKIN,M.SUNNERHAGEN,S.SRISAILAM,M.KARRA,AUTH 3 S.BENCHIMOL,C.H.ARROWSMITHTITL MOLECULAR BASIS OF PIRH2-MEDIATED P53TITL 2 UBIQUITYLATION.REF NAT.STRUCT.MOL.BIOL. V. 15 1334 2008REFN ISSN 1545-9993PMID 19043414DOI 10.1038/NSMB.1521 Variant Set Distributions Mapped Variants