Assessment of Structural Intolerance and Durability
General Structure Information 2edj ROBO2 solution structure of the fifth ig-like domain from human roundabout homolog 2 -1.0Å AUTH C.KUROSAKI,K.IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH IG-LIKE DOMAINTITL 2 FROM HUMAN ROUNDABOUT HOMOLOG 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1z4k NT5M structure of the d41n variant of the human mitochondrial deoxyribonucleotidase in complex with thymidine 3- monophosphate 1.75Å AUTH K.WALLDEN,B.RUZZENENTE,A.RINALDO-MATTHIS,V.BIANCHI,AUTH 2 P.NORDLUNDTITL STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY OF THETITL 2 HUMAN MITOCHONDRIAL DEOXYRIBONUCLEOTIDASEREF STRUCTURE V. 13 1081 2005REFN ISSN 0969-2126PMID 16004879DOI 10.1016/J.STR.2005.04.023 Variant Set Distributions Mapped Variants
General Structure Information 2r55 STARD5 human star-related lipid transfer protein 5 2.5Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Mapped Variants
General Structure Information 1ugk SYT4 solution structure of the first c2 domain of synaptotagmin iv from human fetal brain (kiaa1342) -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,M.SHIROUZU,T.TERADA,T.KIGAWA,AUTH 2 M.INOUE,T.YABUKI,M.AOKI,E.SEKI,T.MATSUDA,H.HIROTA,AUTH 3 M.YOSHIDA,A.TANAKA,T.OSANAI,Y.MATSUO,O.OHARA,AUTH 4 T.NAGASE,R.KIKUNO,M.NAKAYAMA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2 DOMAIN OFTITL 2 SYNAPTOTAGMIN IV FROM HUMAN FETAL BRAIN (KIAA1342)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3kn1 GOLPH3 crystal structure of golgi phosphoprotein 3 n-term truncation variant 2.9Å AUTH C.S.WOOD,K.R.SCHMITZ,N.J.BESSMAN,T.G.SETTY,AUTH 2 K.M.FERGUSON,C.G.BURDTITL PTDINS4P RECOGNITION BY VPS74/GOLPH3 LINKS PTDINSTITL 2 4-KINASE SIGNALING TO RETROGRADE GOLGI TRAFFICKING.REF J.CELL BIOL. V. 187 967 2009REFN ISSN 0021-9525PMID 20026658DOI 10.1083/JCB.200909063 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cqm MRPL17 solution structure of the mitochondrial ribosomal protein l17 isolog -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE MITOCHONDRIAL RIBOSOMALTITL 2 PROTEIN L17 ISOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ux3 FAM96A crystal structure of domain-swapped fam96a minor dimer 1.8Å AUTH K.-E.CHEN,A.A.RICHARDS,J.K.ARIFFIN,I.L.ROSS,M.J.SWEET,AUTH 2 S.KELLIE,B.KOBE,J.L.MARTINTITL THE MAMMALIAN DUF59 PROTEIN FAM96A FORMS TWO DISTINCT TYPESTITL 2 OF DOMAIN-SWAPPED DIMERREF ACTA CRYSTALLOGR.,SECT.D V. 68 637 2012REFN ISSN 0907-4449DOI 10.1107/S0907444912006592 Variant Set Distributions Mapped Variants
General Structure Information 2pz1 ARHGEF4 crystal structure of auto-inhibited asef 2.25Å AUTH N.MITIN,L.BETTS,M.E.YOHE,C.J.DER,J.SONDEK,K.L.ROSSMANTITL RELEASE OF AUTOINHIBITION OF ASEF BY APC LEADS TO CDC42TITL 2 ACTIVATION AND TUMOR SUPPRESSION.REF NAT.STRUCT.MOL.BIOL. V. 14 814 2007REFN ISSN 1545-9993PMID 17704816DOI 10.1038/NSMB1290 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3mx7 FAIM crystal structure analysis of human faim-ntd 1.76Å AUTH G.LI,L.QU,G.MENG,X.BAI,K.DAI,X.ZHENGTITL THE STRUCTURE OF HUMAN FAS APOPTOTIC INHIBITORY MOLECULEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rmn TP63 the solution structure of the p63 dna-binding domain -1.0Å AUTH A.ENTHART,J.FURRER,A.DEHNER,H.KESSLERTITL SOLUTION STRUCTURE AND BINDING STUDIES OF THE P63TITL 2 DNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants