Assessment of Structural Intolerance and Durability
General Structure Information 2bwg GMPR structure of human guanosine monophosphate reductase gmpr1 in complex with gmp 2.4Å AUTH G.BUNKOCZI,A.HARONITI,S.NG,F.VON DELFT,O.GILEADI,AUTH 2 U.OPPERMANN,C.ARROWSMITH,A.EDWARDS,M.SUNDSTROMTITL STRUCTURE OF HUMAN GUANOSINE MONOPHOSPHATE REDUCTASE GMPR1TITL 2 IN COMPLEX WITH GMPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1f05 TALDO1 crystal structure of human transaldolase 2.45Å AUTH S.THORELL,P.GERGELY JR.,K.BANKI,A.PERL,G.SCHNEIDERTITL THE THREE-DIMENSIONAL STRUCTURE OF HUMANTITL 2 TRANSALDOLASE.REF FEBS LETT. V. 475 205 2000REFN ISSN 0014-5793PMID 10869557DOI 10.1016/S0014-5793(00)01658-6 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3w82 IDUA human alpha-l-iduronidase in complex with iduronic acid 2.76Å AUTH N.MAITA,T.TSUKIMURA,T.TANIGUCHI,S.SAITO,K.OHNO,H.TANIGUCHI,AUTH 2 H.SAKURABATITL HUMAN ALPHA-L-IDURONIDASE USES ITS OWN N-GLYCAN AS ATITL 2 SUBSTRATE-BINDING AND CATALYTIC MODULEREF PROC.NATL.ACAD.SCI.USA V. 110 14628 2013REFN ISSN 0027-8424PMID 23959878DOI 10.1073/PNAS.1306939110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1f3u GTF2F1 crystal structure of the rap30/74 interaction domains of human tfiif 1.7Å AUTH F.GAISER,S.TAN,T.J.RICHMONDTITL NOVEL DIMERIZATION FOLD OF RAP30/RAP74 IN HUMANTITL 2 TFIIF AT 1.7 A RESOLUTION.REF J.MOL.BIOL. V. 302 1119 2000REFN ISSN 0022-2836PMID 11183778DOI 10.1006/JMBI.2000.4110 Variant Set Distributions Mapped Variants
General Structure Information 4dbu AKR1C3 crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (akr1c3) in complex with nadp+ and 3-((4 -(trifluoromethyl)phenyl) amino)benzoic acid 2.53Å AUTH M.CHEN,A.O.ADENIJI,B.M.TWENTER,J.D.WINKLER,D.W.CHRISTIANSON,AUTH 2 T.M.PENNINGTITL CRYSTAL STRUCTURES OF AKR1C3 CONTAINING ANTITL 2 N-(ARYL)AMINO-BENZOATE INHIBITOR AND A BIFUNCTIONAL AKR1C3TITL 3 INHIBITOR AND ANDROGEN RECEPTOR ANTAGONIST. THERAPEUTICTITL 4 LEADS FOR CASTRATE RESISTANT PROSTATE CANCER.REF […]
General Structure Information 4imn PTGDS crystal structure of wild type human lipocalin pgds bound with peg mme 2000 2.09Å AUTH S.M.LIM,D.CHEN,H.TEO,A.ROOS,A.E.JANSSON,T.NYMAN,AUTH 2 L.TRESAUGUES,K.PERVUSHIN,P.NORDLUNDTITL STRUCTURAL AND DYNAMIC INSIGHTS INTO SUBSTRATE BINDING ANDTITL 2 CATALYSIS OF HUMAN LIPOCALIN PROSTAGLANDIN D SYNTHASE.REF J.LIPID RES. V. 54 1630 2013REFN ISSN 0022-2275PMID 23526831DOI 10.1194/JLR.M035410 Variant Set Distributions Mapped Variants
General Structure Information 2fs7 CRABP2 crystal structure of apo-cellular retinoic acid binding protein type ii at 1.55 angstroms resolution 1.55Å AUTH S.VAEZESLAMI,E.MATHES,C.VASILEIOU,B.BORHAN,AUTH 2 J.H.GEIGERTITL THE STRUCTURE OF APO-WILD-TYPE CELLULAR RETINOICTITL 2 ACID BINDING PROTEIN II AT 1.4 A AND ITSTITL 3 RELATIONSHIP TO LIGAND BINDING AND NUCLEARTITL 4 TRANSLOCATION.REF J.MOL.BIOL. V. 363 687 2006REFN ISSN […]