Assessment of Structural Intolerance and Durability
General Structure Information 1xwn PPIL1 solution structure of cyclophilin like 1(ppil1) and insights into its interaction with skip -1.0Å AUTH C.XU,J.ZHANG,X.HUANG,J.SUN,Y.XU,Y.TANG,J.WU,Y.SHI,AUTH 2 Q.HUANG,Q.ZHANGTITL SOLUTION STRUCTURE OF HUMAN PEPTIDYL PROLYLTITL 2 ISOMERASE LIKE PROTEIN 1 AND INSIGHTS INTO ITSTITL 3 INTERACTION WITH SKIPREF J.BIOL.CHEM. V. 281 15900 2006REFN ISSN 0021-9258PMID 16595688DOI 10.1074/JBC.M511155200 Variant Set Distributions Mapped […]
General Structure Information 2ns2 SPIN1 crystal structure of spindlin1 2.2Å AUTH Q.ZHAO,L.QIN,F.JIANG,B.WU,W.YUE,F.XU,Z.RONG,H.YUAN,AUTH 2 X.XIE,Y.GAO,C.BAI,M.BARTLAM,X.PEI,Z.RAOTITL STRUCTURE OF HUMAN SPINDLIN1. TANDEM TUDOR-LIKETITL 2 DOMAINS FOR CELL CYCLE REGULATIONREF J.BIOL.CHEM. V. 282 647 2007REFN ISSN 0021-9258PMID 17082182DOI 10.1074/JBC.M604029200 Variant Set Distributions Mapped Variants
General Structure Information 1uff ITSN2 solution structure of the first sh3 domain of human intersectin2 (kiaa1256) -1.0Å AUTH N.KOBAYASHI,T.KIGAWA,S.KOSHIBA,N.TOCHIO,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST SH3 DOMAIN OFTITL 2 HUMAN INTERSECTIN2 (KIAA1256)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c6q GMPR2 crystal structure of human guanosine monophosphate reductase 2 gmpr2 in complex with imp and nadph 1.7Å AUTH G.C.PATTON,P.STENMARK,D.R.GOLLAPALLI,R.SEVASTIK,P.KURSULA,AUTH 2 S.FLODIN,H.SCHULER,C.T.SWALES,H.EKLUND,F.HIMO,P.NORDLUND,AUTH 3 L.HEDSTROMTITL COFACTOR MOBILITY DETERMINES REACTION OUTCOME IN THE IMPDHTITL 2 AND GMPR (BETA-ALPHA)(8) BARREL ENZYMES.REF NAT.CHEM.BIOL. V. 7 950 2011REFN ISSN 1552-4450PMID 22037469DOI 10.1038/NCHEMBIO.693 Variant Set Distributions Mapped Variants
General Structure Information 2qtl MTRR crystal structure of the fad-containing fnr-like module of human methionine synthase reductase 1.9Å AUTH K.R.WOLTHERS,X.LOU,H.S.TOOGOOD,D.LEYS,N.S.SCRUTTONTITL MECHANISM OF COENZYME BINDING TO HUMAN METHIONINE SYNTHASETITL 2 REDUCTASE REVEALED THROUGH THE CRYSTAL STRUCTURE OF THETITL 3 FNR-LIKE MODULE AND ISOTHERMAL TITRATION CALORIMETRYREF BIOCHEMISTRY V. 46 11833 2007REFN ISSN 0006-2960PMID 17892308DOI 10.1021/BI701209P Variant Set […]
General Structure Information 3lgg CECR1 crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ada2) complexed with transition state analogue, coformycin 2.5Å AUTH A.V.ZAVIALOV,X.YU,D.SPILLMANN,G.LAUVAU,A.V.ZAVIALOVTITL STRUCTURAL BASIS FOR THE GROWTH FACTOR ACTIVITY OF HUMANTITL 2 ADENOSINE DEAMINASE ADA2.REF J.BIOL.CHEM. V. 285 12367 2010REFN ISSN 0021-9258PMID 20147294DOI 10.1074/JBC.M109.083527 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1fo3 MAN1B1 crystal structure of human class i alpha1,2-mannosidase in complex with kifunensine 1.75Å AUTH F.VALLEE,K.KARAVEG,A.HERSCOVICS,K.W.MOREMEN,AUTH 2 P.L.HOWELLTITL STRUCTURAL BASIS FOR CATALYSIS AND INHIBITION OFTITL 2 N-GLYCAN PROCESSING CLASS I ALPHA 1,2-MANNOSIDASES.REF J.BIOL.CHEM. V. 275 41287 2000REFN ISSN 0021-9258PMID 10995765DOI 10.1074/JBC.M006927200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1ue9 ITSN2 solution structure of the fourth sh3 domain of human intersectin 2 (kiaa1256) -1.0Å AUTH N.TOCHIO,T.KIGAWA,S.KOSHIBA,N.KOBAYASHI,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH SH3 DOMAIN OFTITL 2 HUMAN INTERSECTIN 2 (KIAA1256)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cre CASS4 solution structure of rsgi ruh-036, an sh3 domain from human cdna -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-036, AN SH3 DOMAINTITL 2 FROM HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2pz1 ARHGEF4 crystal structure of auto-inhibited asef 2.25Å AUTH N.MITIN,L.BETTS,M.E.YOHE,C.J.DER,J.SONDEK,K.L.ROSSMANTITL RELEASE OF AUTOINHIBITION OF ASEF BY APC LEADS TO CDC42TITL 2 ACTIVATION AND TUMOR SUPPRESSION.REF NAT.STRUCT.MOL.BIOL. V. 14 814 2007REFN ISSN 1545-9993PMID 17704816DOI 10.1038/NSMB1290 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants