Assessment of Structural Intolerance and Durability
General Structure Information 4gnk PLCB3 crystal structure of galphaq in complex with full-length human plcbeta3 4.0Å AUTH A.M.LYON,S.DUTTA,C.A.BOGUTH,G.SKINIOTIS,J.J.TESMERTITL FULL-LENGTH G ALPHA (Q)-PHOSPHOLIPASE C-BETA 3 STRUCTURETITL 2 REVEALS INTERFACES OF THE C-TERMINAL COILED-COIL DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 20 355 2013REFN ISSN 1545-9993PMID 23377541DOI 10.1038/NSMB.2497 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3f8u TAPBP tapasin/erp57 heterodimer 2.6Å AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f8u TAPBP tapasin/erp57 heterodimer 2.6Å AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3jts B2M gy9-mamu-a*02-hb2m 2.8Å AUTH L.DAITITL STRUCTURE OF MAMU A*2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1s31 TUB crystal structure analysis of the human tub protein (isoform a) spanning residues 289 through 561 2.7Å AUTH S.BOUTBOUL,K.J.CARROLL,A.BASDEVANT,C.GOMEZ,E.NANDROT,AUTH 2 K.CLEMENT,L.SHAPIRO,M.ABITBOLTITL A NOVEL HUMAN OBESITY AND SENSORY DEFICIT SYNDROME RESULTINGTITL 2 FROM A MUTATION IN THE TUB GENEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2qnk HAAO crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase 1.6Å AUTH E.BITTO,C.A.BINGMAN,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF HUMAN 3-HYDROXYANTHRANILATETITL 2 3,4-DIOXYGENASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ihi AKR1C2 crystal structure of human type iii 3-alpha-hydroxysteroid dehydrogenase/bile acid binding protein (akr1c2) complexed with nadp+ and ursodeoxycholate 3.0Å AUTH Y.JIN,S.E.STAYROOK,R.H.ALBERT,N.T.PALACKAL,AUTH 2 T.M.PENNING,M.LEWISTITL CRYSTAL STRUCTURE OF HUMAN TYPE IIITITL 2 3ALPHA-HYDROXYSTEROID DEHYDROGENASE/BILE ACIDTITL 3 BINDING PROTEIN COMPLEXED WITH NADP(+) ANDTITL 4 URSODEOXYCHOLATE.REF BIOCHEMISTRY V. 40 10161 2001REFN ISSN 0006-2960PMID 11513593DOI 10.1021/BI010919A […]
General Structure Information 1ntg YARS crystal structure of the emap ii-like cytokine released from human tyrosyl-trna synthetase 2.21Å AUTH X.-L.YANG,J.LIU,R.J.SKENE,D.E.MCREE,P.SCHIMMELTITL CRYSTAL STRUCTURE OF AN EMAP-II-LIKE CYTOKINETITL 2 RELEASED FROM A HUMAN TRNA SYNTHETASEREF HELV.CHIM.ACTA V. 86 1246 2003REFN ISSN 0018-019XDOI 10.1002/HLCA.200390107 Variant Set Distributions Mapped Variants
General Structure Information 1xke RANBP2 solution structure of the second ran-binding domain from human ranbp2 -1.0Å AUTH J.P.GEYER,R.DOKER,W.KREMER,X.ZHAO,J.KUHLMANN,AUTH 2 H.R.KALBITZERTITL SOLUTION STRUCTURE OF THE RAN-BINDING DOMAIN 2 OFTITL 2 RANBP2 AND ITS INTERACTION WITH THE C TERMINUS OFTITL 3 RAN.REF J.MOL.BIOL. V. 348 711 2005REFN ISSN 0022-2836PMID 15826666DOI 10.1016/J.JMB.2005.02.033 Variant Set Distributions Mapped Variants
General Structure Information 4efg RBP2 crystal structure of the q108k:k40l:t51v:t53c:y19w:r58w:t29l mutant of cellular retinol binding protein type ii in complex with all-trans- retinal at 1.58 angstrom resolution 1.58Å AUTH W.WANG,Z.NOSSONI,T.BERBASOVA,C.T.WATSON,I.YAPICI,K.S.LEE,AUTH 2 C.VASILEIOU,J.H.GEIGER,B.BORHANTITL TUNING THE ELECTRONIC ABSORPTION OF PROTEIN-EMBEDDEDTITL 2 ALL-TRANS-RETINAL.REF SCIENCE V. 338 1340 2012REFN ISSN 0036-8075PMID 23224553DOI 10.1126/SCIENCE.1226135 Variant Set Distributions Mapped Variants